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Splitting or crushing Seroquel 25mg tabs Will crushing work Rate Topic: -----

#1 User is offline   lemonflavor 

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Posted 06 April 2006 - 03:42 PM

I'm going to start taking 12.5mg of Seroquel for sleep. (I've taken Seroquel before and am familiar with it.) The 25s don't split real easily, even in a good pill splitter. Can these be crushed and put in juice and divided up that way?

Not sure if this should go here or pharmacology forum.
BP II (MDD, PD, GAD) Insomnia
Lamictal 75mg, Lexapro 20mg, Inderal 50mg, Klonopin 1.5mg, 7.75mg Remeron-sleep
Pain: MS Contin 90mg day, Percoset 40mg (oxycodone) day
As needed: Ambien, tramadol
Past Rx: almost every AD you can think of, Zyprexa, Seroquel, Risperdal, Trileptal, Depakote, Lithium, Deplin, Gabapentin, Baclofen, Cyclobenzaprine, Zanaflex

#2 User is offline   Velvet Elvis 

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Posted 06 April 2006 - 05:05 PM

I'd ask a pharmacist.  You might be able to get them to split them for you.

I'm supprised that little does much of anything.


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#3 User is offline   lemonflavor 

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Posted 06 April 2006 - 05:54 PM

25mg will have me asleep for 11 hours plus a nap. I may adjust to the 12.5 and need to go up to 25mg. But at 50mg after it builds up it makes me skin-crawly for some strange reason so it's a delicate balance I'm trying for. 
BP II (MDD, PD, GAD) Insomnia
Lamictal 75mg, Lexapro 20mg, Inderal 50mg, Klonopin 1.5mg, 7.75mg Remeron-sleep
Pain: MS Contin 90mg day, Percoset 40mg (oxycodone) day
As needed: Ambien, tramadol
Past Rx: almost every AD you can think of, Zyprexa, Seroquel, Risperdal, Trileptal, Depakote, Lithium, Deplin, Gabapentin, Baclofen, Cyclobenzaprine, Zanaflex

#4 User is offline   Dee 

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Posted 06 April 2006 - 06:00 PM

I can take 25 mg in the morning and I'm still a spinning top. :(
"I may be dead, but I'm still pretty."~ Buffy

DX: BP1, GAD

RX: Trileptal 1350 mg, Topamax 100 mg, Lexapro 10 mg, Effexor 225 mg, Seroquel 150-200 mg, Clonazepam prn.

#5 User is offline   Supergwen 

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Posted 07 April 2006 - 07:49 AM

I've split some of my seroquel, you have to have a very thin knife or a straight razor (although I will NOT have those in my house - things I could possibly use to kill myself are a baaaaaaad idea.  I don't even like having a gas stove....).  They do tend to get a little funky, but they still do the job.  Maybe ask if someone with steady hands can do it?  Also, I have learned that it helps to have a longer knife, and put the tip on the cutting board and use the thicker part towards the handle to cut the pill.  Damn round seroquel.  Do they make 12.5 pills?  I dunno. 

I have to take 25mg very early in the night, so that I don't feel like a complete zombie in the AM.  1/2 a pill is much better, let's me rest w/o putting me in a virtual coma.  When I was batshit and constantly hypo I could take 25 2xs/day and be fine. 

Sounds like we use Seroquel for the same stuff!

This post has been edited by Supergwen: 07 April 2006 - 07:50 AM

BPII
AM = 150mg Effexor, 200mg Lamictal
PM = 150mg Effexor, 200mg Lamictal, 2.5mg abilify


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#6 User is offline   hollow log 

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Posted 10 April 2006 - 09:57 AM

Yeah it's a bitch that there isn't 12.5mg tabs... I started off taking that amount, and I got a pretty good nights sleep out of it.  I'm on 175mg now, but that's more for anxiety, and paranoia. But, for sleep this med kicks major fucking arse.
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#7 User is offline   lemonflavor 

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Posted 10 April 2006 - 10:18 AM

For now I've been using a pill splitter (which has a razor blade in it) and I can get them in half 2 out of 3 times. The other time I just take the bigger half or try to even it out, but they're a little crumbly so it's hard to cut off a tiny piece. I may need to go up to 25mg anyway.
BP II (MDD, PD, GAD) Insomnia
Lamictal 75mg, Lexapro 20mg, Inderal 50mg, Klonopin 1.5mg, 7.75mg Remeron-sleep
Pain: MS Contin 90mg day, Percoset 40mg (oxycodone) day
As needed: Ambien, tramadol
Past Rx: almost every AD you can think of, Zyprexa, Seroquel, Risperdal, Trileptal, Depakote, Lithium, Deplin, Gabapentin, Baclofen, Cyclobenzaprine, Zanaflex

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Posted 15 December 2009 - 01:08 PM

DO NOT split or crush seroquel unless you know what you are doing.

You shouldn't split pills because of following (generic) reasons:

- seroquel is major tranqualizer and it can have harmful effects to brain
- pills are hard on purpose so that seroquel is released to body more
slowly and the peak concentration of seroquel is lower
- if you crush the pills the powder is absorbed much faster (bad)
+ if you find seroquel/quetiapine pills that are meant to splitted
then it is save to split but AFAIK there aren't any
(they are more expensive to make)

I made the mistake of splitting pills (for a month) and now
I have hard time using a single pill instead of two split ones.
(The solution: gradually going away from split pills:
0.5+0.5, 0.8+0.2, 0.9+0.1, 1.0)

If you only use pills for sleep then I think you could save money
by using split pills at lower doses (you get the same peak seroquel
concentration that knocks you into sleep) BUT I wouldn't want to risk
my brain's overall healthiness by saving few bucks. As a result you
may also wake up during the middle of the night when the seroquel
levels go down too quickly.
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