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When Klonopin does not work.

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#1 greenie



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Posted 20 February 2007 - 09:14 PM

Brief description (This is my first post, i hope i am doing this right) I got off Paxil October 1st 2006, the paxil made my anxiety worse and i lost a lot of weight. I was at 130 then dropped to 112, i am 5 foot 8in. I was diagnosed with PPD and PPA. Well that is all done and over with. I had twin boys that are now 3 yrs old. I have been off and on Klonopin and Xanax at different times. I am currently taking Klonopin 1mg 4 times a day, sometimes i double or triple my dose cause i feel NO relief.
I was wondering if beer has any effect on my Klonopin. However i do not get sleepy i actually get more agitated. I am a stay at home mom and do not get out of the house, due to anxiety and panic attacks.
I am dealing with insomnia and taking Ambien CR, which i still wake up in the middle of the night sometimes. I see my DR in March. He is not a real fan off Antidepressants, thank god cause it gives me NO sex drive. And i do not feel depressed. I am just curious why i am not getting any relief from the Klonopin. I have tried Buspar (what a joke) i tried it for a month, and nothing. I know Klonopin is takes a while to hit you, and the Xanax hits fast, however it runs out of my system fast so i have to take more....Am i making any sense???? lol
I will be posting a lot and i hope i can give advice as i would also like to get advice.
Remember.....This is my first post so be easy ;)

#2 Penny Century

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Posted 20 February 2007 - 09:48 PM

I was wondering if beer has any effect on my Klonopin.


booze+benzos=bad idea

people are different, so some people get weird and agitated when they mix alcohol and benzos, but the reality is that it is not safe. esp. at the doses you're taking.

have you talked to your doctor about how your dosage isn't working out?

if antidepressants don't help, you may want to look at atypicals (seroquel, risperdal, zyprexa, abilify, etc.) or anticonvulsants (lamictal, lyrica, tegretol, etc.) to control your anxiety and help you sleep.
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#3 chimpmaster


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Posted 05 March 2007 - 09:45 PM

It sounds like you have built up tolerance to the klonopin. Here are a couple of tips:

- waiting for it to kick in is important. It doesnt work instantly and sometimes a wait can be well worth it.
- changing benzos may help. Talk to your dr about valium and atvian.

Good luck


Dx : Schizophrenia, paranoid type with panic attacks. Obsessive Compulsive Personality Trait, epilepsy

Rx : 300mg Clozapine, 1500mg Keppera, 60mg Prozac, 160mg Zeldox, 4mg Reboxetine, 3 oxazepam morning and lunch, 3 in the evening
Ex Rx: Luvox, Paxil, Risperdel, Xanax, Seroquel, Abilify, Zyprexa, Tolvon, Mirtazapine, diazepam.

#4 myevilme



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Posted 07 March 2007 - 06:02 PM

If my klonopin isn't working 2 hours after I take it I pop 200mg of seroquel. I don't know if you've tried atypical anti-psychotics, but they work pretty good for anxiety, for me anyway.
Psych Diagnoses: Bipolar (never asked which flavor, just give me something to fix it!) GAD & Panic Disorder (don't know why they put both down on my charts, feels the same to me)

Other Problems:

invega 9mg (formerly 800mg seroquel)
1200 Neurontin
45 remeron
3mg klonopin

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Lexiva, Epzicom, Norvir

#5 LikeMinded


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Posted 07 March 2007 - 09:31 PM


a hearty (Burroughs?) welcome to you.

If you really are concerned about your weight dropping, maybe an AAP (a la Seroquel or Zyprexa) may be right for you. They're both excellent knockout pills, for what it's worth. And they're both known for causing profound weight gain, and in Zyprexa's case, it's been well-researched that this weight gain is due to it dorking with your blood sugar, with extreme prejudice.

That said, in my "panic packet" (a couple pills in my wallet that I keep *just in case*), there's a pill of 2.5mg Zyprexa, though not for insomnia, it's more for if I'm about to explode in somebody's face, which rarely has occurred.

I didn't get along with regular-basis treatment with Zyprexa, since it caused me severe akathisia (a feeling best described by fear, disgust, panic, depression, and the worst God-awful impatience you can think of... all rolled into one dysphoria). There's also the risk of extrapyrmidal symptoms (akathisia is one of them), which also include shakiness and tremor, stuff similar to parkinsonian diseases. AAPs can be miracles to some people, but they're not drugs to dork around with freely.

I used to use Klonopin for sleep, but the dose (4mg) required to give me a good night's worth also messed up my respiratory system and gave me "central sleep apnea" (which is when your breathing dramatically slows or even stops on occasion!), and therefore made me wake up every morning walking about as if I were drunk. This directly led to my Christmas Day present last year (which was a severe concussion).

So for sleep I now use Dalmane (aka flurazepam), which at least judging by the clinical data (and my own pdoc's advice), is a relatively benign benzo that has a slow "on" and "off" effect. That is to say, it takes a couple days to start working (as it builds in your bloodstream), and takes often up to 2 weeks before you get that fun rebound insomnia.

That's just my two cents, well okay, one cent, I'm short on cash at the moment, so talk to your psychiatrist about the suggestions mentioned above.

CAUTION: I'm a graduate computational medicine/allied health information student, and NOT a licensed clinician of any sort in any part of the world.  I can come up with lots of algorithms, generalities, and statistics but cannot provide specific medical advice for you!  You, along with your healthcare provider/pdoc/tdoc/etc. are the best decision makers for what is best!


Me: MDD, AD/HD, HFA/PDD-NOS/Partial Neurotypicality/WTF, REM behavioral disorder/misc. sleep issues, some variant of PTSD... toss in hypothyroidism, post-meningitis-related Parkinson's disease/tremor, early stage pulmonary hypertension from a connective tissue disorder that wants me dead before age 60, and a few misc. manly hormone issues, and you'll get a few insights on where that PTSD came from.


Now on: Cymbalta, mirtazapine, oxybutynin, clonazepam, lamotrigine, clonidine, levothyroxine, metformin, Testim.  As Velvet Elvis implied, I sound like a freakin' maraca salesman when I go through airport security.

#6 scatty


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Posted 07 March 2007 - 11:57 PM

Klonopin doesn't totally knock out my anxiety. I have come to rely on risperdal to do that. I never knew how bad it was until it got better.

Bipolar I & Anxiety.  Self diagnosed cunt.

My New (old) Meds: (usually these keep me the most stable)
Lithium ER 1350 mgs.
Lamictal 200 mgs.

Klonopin 2 mgs.

Abilify 15 mgs.


Practicing CBT, DBT, and ACT self-help therapy.

Crazy since the 80's!

#7 Tom


    I may not look like it, but I am not stable

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Posted 08 March 2007 - 08:11 PM

Klonopin doesn't totally knock out my anxiety. I have come to rely on risperdal to do that. I never knew how bad it was until it got better.

Same here. I'm also on Risperdal besides clonazepam.

dx: anxiety and depression
current meds: Invega 3mg, Clonazepam 6mg, Inderal 40mg, Cipralex 20mg
previous meds: Paxil (did nothing except i wasn't able to achieve the big O), Zyban, Effexor, Celexa, Remeron, Xanax, Ativan, Neurontin, Zoloft (useless), Wellbutrin XL (a joke), Buspar (made me suicidal), Moclobemide (made anxiety worse), Nardil (crapshot. Didn't do anything good and made me faint from low BP), Zyprexa, Seroquel (nope, no sedation), Atenolol (didn't stop the shakes), Imipramine, Doxepin, Risperdal, Lamictal (made anxiety bad), Cymbalta (fail), Lyrica

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