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Experiences With Wellbutrin @ 450mg


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#1 Loon-A-TiK

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Posted 20 September 2007 - 12:40 PM

i've been in a funky depression lately, and finally got my pdoc to do something about it. he decided to increase my WB up to 450mg.

have any of you had success with this increase? has it been a bad thing? i know i may get some additional anxiety, but i have klonopin for that.
DX-BP1 w/psychotic symptoms, PTSD, ADD (Inattentive), and body dysmorphic disorder
Daily RX- WB 300mg, Lamictal 400mg, Abilify 20mg, Adderall XR 30mg, Inderal 10mgx2, Nuvaring
a multi-vitamin, hair/skin/nails vitamin, super 50-b complex vitamin, flax oil

prn- Zyprexa 10-20mg for emergencies

In memory of my dad, BP1 suicide. I love you and miss you!

EX RX- Seroquel, Risperdal, Geodon (master of all that is evil), Zyprexa (the good stuff), Zyprexa Zydis, Trazadon, Depakote, Lithium, Serzone, Paxil, Effexor, Lexapro, Haldol, Strattera, Topamax, Symmetrel, other old school ACs, and more I can't remember now

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#2 goldfinch

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Posted 20 September 2007 - 03:33 PM

I went through a really bad period last summer, and my pdoc increased my dosage from 300mg to 450mg. Within a very short period of time I was feeling great. I stayed on the 450mg for a few months because I enjoyed the side effect of loss of appetite. However I also had insomnia, head buzzing and very dry mouth and I couldn't take those, so I'm back down to 300mg.

#3 meg

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Posted 20 September 2007 - 04:42 PM

hey loon,
I upped my wb from 300 to 450 about 6 months ago and it's been a lifesaver (yet again, thanks wellbutrin)--
I have the problem of wb 'pooping out' on me every few months and the last time it did that I was upped to 450...
within a few weeks I was feeling much better- and didn't notice any increase in side effects (at least none that didn't go away in a week or two). worth a shot imo.
ohoh, keep in mind that I've never had any anxiety issues (so wb never created or added to anxiety for me) and that it has never kept me awake so I don't know how it would affect someone who it keeps awake at 300. just wanted to make sure you take my experience with that grain of salt.
goodluck!
let us know how it goes,
meg

warning: I often write novels vs. posts-- please skim if you need to, just don't get scared off by the quantity of babble!

  • me: am 22 years old (feel about 90 sometimes), am a photographer (just finished my degree!) and makeup artist
  • dx: april'07: "mdd and adhd (inattentive)," mid'08: tack on "hyper-somnolence" (ie: meg sleeps too much)
  • mdd rx: wellbutrin xl 450mg, zoloft (sertraline) 150mg, lamictal 100mg
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#4 Greenyflower

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Posted 21 September 2007 - 12:24 AM

I've been at 450 for a couple of years now with no problems. I was so depressed when I went from 300 to 450 that I wouldn't have noticed a side effect if it had turned my skin purple.
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#5 Loon-A-TiK

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Posted 21 September 2007 - 09:51 AM

this is my second day on 450 and i feel the same (predictably).
when should it start to kick in?
DX-BP1 w/psychotic symptoms, PTSD, ADD (Inattentive), and body dysmorphic disorder
Daily RX- WB 300mg, Lamictal 400mg, Abilify 20mg, Adderall XR 30mg, Inderal 10mgx2, Nuvaring
a multi-vitamin, hair/skin/nails vitamin, super 50-b complex vitamin, flax oil

prn- Zyprexa 10-20mg for emergencies

In memory of my dad, BP1 suicide. I love you and miss you!

EX RX- Seroquel, Risperdal, Geodon (master of all that is evil), Zyprexa (the good stuff), Zyprexa Zydis, Trazadon, Depakote, Lithium, Serzone, Paxil, Effexor, Lexapro, Haldol, Strattera, Topamax, Symmetrel, other old school ACs, and more I can't remember now

"Can a selfish egocentric jealous and unimaginative female write a damn thing worthwhile?" - Sylvia Plath

If you don't have something nice to say, then don't say it at all.

#6 Velvet Elvis

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Posted 21 September 2007 - 12:22 PM

It helped me a lot. Unfortunately it made me feel like I was constantly on a down elevator. Out of concern that this might be seizure activity and since I have no insurance to pay for an EEG I had to go off it.

It will probobly take as long to kick in as it did when you first started taking it. It has several active metabolites so it might come in waves.

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#7 Loon-A-TiK

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Posted 24 September 2007 - 05:10 PM

that sucks for you, VE, that it didn't work out. i like WB a lot.
i don't remember how long it took to start working. i was coming down off of paxil and starting WB at the same time, so it started sometime during the switch. maybe it took a couple of weeks?
DX-BP1 w/psychotic symptoms, PTSD, ADD (Inattentive), and body dysmorphic disorder
Daily RX- WB 300mg, Lamictal 400mg, Abilify 20mg, Adderall XR 30mg, Inderal 10mgx2, Nuvaring
a multi-vitamin, hair/skin/nails vitamin, super 50-b complex vitamin, flax oil

prn- Zyprexa 10-20mg for emergencies

In memory of my dad, BP1 suicide. I love you and miss you!

EX RX- Seroquel, Risperdal, Geodon (master of all that is evil), Zyprexa (the good stuff), Zyprexa Zydis, Trazadon, Depakote, Lithium, Serzone, Paxil, Effexor, Lexapro, Haldol, Strattera, Topamax, Symmetrel, other old school ACs, and more I can't remember now

"Can a selfish egocentric jealous and unimaginative female write a damn thing worthwhile?" - Sylvia Plath

If you don't have something nice to say, then don't say it at all.

#8 oceanlover

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Posted 28 September 2007 - 02:51 PM

I went up to 450 around 6-8 weeks ago and did feel better, just little more of headache, but still spirled into this depression I got last week.

my best to you!

laura

Edited by oceanlover, 28 September 2007 - 02:51 PM.

now.. wellbutrin 300...folate...cytomel.... klonopin...
old Rx...wellbutrin 450 [brand] effexorXR 37.5..provigil 200-400..folate..
dx..bipolar 2

#9 Loon-A-TiK

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Posted 28 September 2007 - 06:22 PM

well, so far i haven't noticed any change, but it's only been a little over a week since the increase.
DX-BP1 w/psychotic symptoms, PTSD, ADD (Inattentive), and body dysmorphic disorder
Daily RX- WB 300mg, Lamictal 400mg, Abilify 20mg, Adderall XR 30mg, Inderal 10mgx2, Nuvaring
a multi-vitamin, hair/skin/nails vitamin, super 50-b complex vitamin, flax oil

prn- Zyprexa 10-20mg for emergencies

In memory of my dad, BP1 suicide. I love you and miss you!

EX RX- Seroquel, Risperdal, Geodon (master of all that is evil), Zyprexa (the good stuff), Zyprexa Zydis, Trazadon, Depakote, Lithium, Serzone, Paxil, Effexor, Lexapro, Haldol, Strattera, Topamax, Symmetrel, other old school ACs, and more I can't remember now

"Can a selfish egocentric jealous and unimaginative female write a damn thing worthwhile?" - Sylvia Plath

If you don't have something nice to say, then don't say it at all.

#10 ehygon

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Posted 28 September 2007 - 06:56 PM

I was raised from 300 o 450 of wellbutrin xl. so far, i've felt worse, and have double vision and weird migraine auralike problems. Can't say i'm a fan. That being said, i think wellbutrin pooped out on me in general, and the increase just didnt do anything.

#11 wm blair

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Posted 06 October 2007 - 12:26 AM

I had been having a *phunky depression also and had had a problem with something near dissociative i bit almost but

my meddoc "fancy pants" is the first competent meddoc I have had on the west coast. which is nice.

He noticed that I was depressed

he thought we should up to 450mg

but I thought the thing was to switch from the generic which didn't work because its time release didn't work right

so then all at once I went from screwy 300 mg to full 450mg

plus this was my first week of graduate school

plus I had some issues with knowing people who died




-------
adderall xr 15 --clonozepam .5-1.5 per day as needed - zyrtec 10 --effexor xr 225
ptsd. aspie. anxiety. depression.

Edited by wm blair, 06 October 2007 - 12:27 AM.


#12 Greenyflower

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Posted 09 October 2007 - 07:58 PM

Soooo...

You went from 300 mgs of either budeprion or bupropion ( budeprion is an oblong yellow tablet, and the generic bupropion is white and looks a lot like the real brand name wellbutrin) to 450 of Wellbutrin XL?

I found the 450 mgs of wellbutrin to be very helpful, but definitely a little speedy at first. That didn't take long to stop.
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#13 Guest_Guest_*

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Posted 13 June 2009 - 06:34 AM

I just did a search on the boards because I recently (1 month ago) increased from namebrand WBXL300 to 450mg and am feeling really down, blue, worthless and negative. I have no energy and am feeling like I am moving backwards. I am fine at work, somehow I seem to pull it off getting through my shifts like some superhuman, but when I get home I am sad, crabby, socially isolative and I have two daughters. Recently went through my daughters backpack and saw a picture she made- it was her reading to me and me laying in bed. It really got to me. I can't take this much more, it makes me feel horrible. I notice that the feelings wax and wane most with the weather as well. I slept nearly non-stop for the past 36hours.

#14 olga

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Posted 13 June 2009 - 09:03 AM

Guest, time to call your pdoc and make an appointment. Maybe the increase isn't good for you. Maybe you should be on another AD. It sounds to me like to need to talk to your doctor quickly.

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#15 null0trooper

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Posted 13 June 2009 - 10:40 AM

I just did a search on the boards because I recently (1 month ago) increased from namebrand WBXL300 to 450mg and am feeling really down, blue, worthless and negative. I have no energy and am feeling like I am moving backwards. I am fine at work, somehow I seem to pull it off getting through my shifts like some superhuman, but when I get home I am sad, crabby, socially isolative and I have two daughters.


1. Zero energy
2. irritable
3. even MORE depressed
4. hypersomnia

Yep, raising the prescription clearly didn't help. See your doctor soon - this sort of thing doesn't get better by itself on the noradrenergics.

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#16 Lanhua

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Posted 13 June 2009 - 11:10 AM

I was on 300mg (along with a bunch other meds) and I went down to 150mg b/c my DR thought it might be causing too much anxiety. I'm not sure it really was?? Otherwise I've had no side affects even at 300mg. I like Wellbutrin a lot.
Bipolar 2 ultra-rapid cycling, BPD
Prozac 40mg
Wellbutrin
150mg
Lamictal 300mg
Risperdal 4 mg
Topamax 75mg (titrating up to 200mg)


old
RX:
, Lexapro 20mg, Wellbutrin 300mg , Lithium 300mg, Paxil 12.5mg, 180mg Geodon





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