Nuvigil and Depression
#1
Posted 31 July 2009 - 12:17 AM
Thanks in advance!
#2
Posted 31 July 2009 - 10:13 AM
Both are wakefulness promoting agents, approved for use with narcolepsy, the side effects of obstructive sleep apnea, or shift work sleep disorder. They are used off label for all sorts of other things, one of which happens to be depression.
In terms of attention and focus, these are exactly what they are called - wakefulness promoting agents. If you've been awake for 30 hours and your brain has turned to jello, taking one of these medicines will result in your brain continuing to be jello but you will find it easier to keep that jello awake for a few more hours. Taking one of these meds won't necessarily help your cognition, but if sleepiness is what was clouding your mind then - yes you will see an improvement.
The effect on anxiety is a crap shoot. Increased anxiety is a possible side effect. Some people get it. Some people feel less anxiety on these meds. YMMV
Unlike stims these meds won't fuck up your sleep. The deal is that if you choose to be awake, the medicine will make it easier to do so. However if you choose to be asleep, the med won't get in the way of that.
Using it for depression is eh. It's not that the wakefulness promoting agents are going to improve depression, but they treat some of the common side effects of depression (sleepiness, lethargy) and as add on's to AD's they can sometimes be a big help in keeping your energy up during the day.
It's not a stimulant, but it's still an upper. Abuse happens. Respect your prescription.
~ May
When life itself seems lunatic, who knows where madness lies? Perhaps to be too practical is madness. To surrender dreams - this may be madness. To seek treasure where there is only trash. Too much sanity may be madness. And maddest of all, to see life as it is and not as it should be.
-Don Quioxite, The Man of La Mancha
#3
Guest_Margo_*
Posted 05 September 2009 - 08:25 PM
I wish I knew what to do.
Margo
#4
Posted 05 September 2009 - 10:06 PM
My doctor just put me on Nuvigil. I have taken it two days in a row.
Not many people see consistent improvement in the first few days of any medication change.
It sucks, but you're going to have to give it more than two days to see if the new medication
works out.
I wish I knew what to do.
If you do not have a therapist/counsellor/psychologist yet, get one. Your post suggests that
you may have more to tend to than you can be reasonably expected to work on without more
support than a pill or two a day can provide. If you have one already and aren't getting
enough support, it might be time to start looking for a replacement.
Proof once again that we are the only adventurers for whom the letters "AD&D" stand for "Attention Deficit Disorder" - Roy Greenhilt, Order of the Stick
Rule your own nation at Cyber Nations, A nation simulation game! Yes, I do waste spend a lot of time on it, especially the Viridian Entente's alliance boards.
#5
Guest_Zoe_*
Posted 26 February 2010 - 03:07 PM
I've been on some other forums of folks taking Nuvigil (MS forums, ADD forums) and I haven't seen any other group talking about ill effects from Nuvigil. I'm thinking it might just cause spikes in depression for those of us who already have it. Everyone's different though, and unfortunately, the only way to know how it will affect you is to try it :T Best of luck.
#6
Guest_Margaret_*
Posted 03 March 2010 - 02:09 PM
#7
Guest_Tara_*
Posted 05 March 2010 - 01:33 PM
I was put on Nuvigil to help with my fatigue issues. After 19 years of living with exhaustion and feeling like my mind is living in a fog, I was so excited to start feeling better. It took about a week to see any real results, but they were completely positive!
About 10 days later, I wanted to cry. I cry as soon as I think of something sad (not focus on something sad, just a fleeting thought). The depression I am experiencing is mind boggling.
I fought taking antidepressants for years. FOUGHT. I was not depressed. I was frustrated. Frustrated by not feeling well. And now, I have to fight with myself NOT to call the doctor and ask for an anti-depressant.
As soon as I started feeling depressed, I looked at the information and side effects of Nuvigil. I never want to give myself some kind of pre-disposition towards symptoms, so I just take the medication and deal with the effects later. As soon as I realized depression was a listed symptom, I breathed a sigh of relief. Typically, I can deal with that which I can understand. For a few days, this worked. I told myself I was happy. I told myself I was not depressed. I told myself, look at how much better you feel overall by taking this!
Yeah, okay, so that is not working too well right now. The tearing up is getting worse. I am more depressed. If it does not improve soon, I will have to call my doctor. Sadly, I do not know which is worse: this depression or the mental fog. I almost think I rather deal with the depression. At least I can clearly evaluate how depressed I am. *lol*
#8
Posted 21 March 2010 - 05:46 PM
For what that is worth.
Captain Yaaar, could you be having a paradoxical reaction?
Dx: Bipolar NOS; GAD; Migraine w/ Aura; Migraine w/o Aura;
Rx: Alprazolam; Botox; Buproprion; Dihydroergotomine via IV Infusion; Imitrex Tablets with Metoclopramide; Lamotrigine; Lithium; Migranal; Prilosec; Promethazine; Propranalol; Sumatriptan injectables
Currently Shelved: Abilify; Amerge; Anaprox; Atenolol; Buspar; Cafergot; Cymbalta; Depakote; Di-Hydro-ergotamine; injected; Gabapentin; Geodon; Klonopin; Maxalt; Namenda; Nortriptyline; Norvasc; Prozac; Risperdone; Relpax; Sansert; Tegretol; Trazadone; Verapamil; Zoloft; Zolpidem; Zomig; Zonegran
Affectations can be dangerous. -Gertrude Stein
#9
Guest_Tara_*
Posted 15 April 2010 - 07:41 PM
After 3 days of continuous crying, I called my doctor. I started by telling him that the medication was really doing what it was designed to do, I was alert. I was awake. REALLY awake for the first time in almost 19 years. I went on to explaint that the depression I expereienced as a side effect, however, was worse than I could have ever imagined and that I was becoming overly emotional for no reason.
He did not think it was the medication. He offered to put me on an anti-depressant, gently suggesting that after everything I had been through, I should not worry about realizing I was actually very depressed. I paused. I had actually callled with the intent of demanding an anti-depressant. After fighting against the "she is just depressed" mantra for so long, did I really want to give in now? I asked about the possibility of decreasing the dosage or taking it every other day. He responded, Tara, it is not the medication. I gritted my teeth, saying nothing but knowing better.
I did not make a habit of thinking how great it would be to drive into 18 wheelers and concrete medians during my commute to/from work or other random thoughts that could be described as suicidal in nature. I had never expereinced these levels of depression, not even close. It made no sense, I was feeling BETTER. Why would I be depressed now?
I decided to keep taking the medication. As prescribed. Fight through it. See if in time, my body would/could adjust. Let me tell you, those next 8 days or so were pure hell. There is just no other way to describe it, but I was stubbornly resolved to prove it was NOT me.
Then, I woke up, almost 4 weeks to the day I started taking Nuvigil. I blinked. I was awake. I could think. I was not exhausted. I was not even mildly tired. AND I was not depressed or crying. I had made it. In fact, I felt better than I had since I was 14 years old. And as I sit here typing this three weeks later, I still feel the same.
So for those expereincing something similar, try to stick with it. There is a light at the end of the tunnel. It is so worth it!
Now, I am in the process of fighting with my insurance to cover the medication. I know I need it, so if I have to pay for it out of pocked, so be it. My doctor has been great, giving me additional samples while we appeal their decision. I hope they do cover it (I have been officially diagnosed with both OSA and Narcolepsy among others), but I will cut out cable television and home internet access before I will go back to life as it was before Nuvigil. All I can do is say thanks to those who worked to develop something that works. The road was not easy. Yet, it was definitely worth traveling. As Frost so famously penned: "And I, I took the road less traveled by and it has made all the difference."
~Tara
#10
Guest_Gina_*
Posted 22 April 2010 - 11:28 PM
#11
Guest_Scott_*
Posted 28 April 2010 - 11:54 AM
I've been taking Nuvigil for about 5 or 6 months now. I'm taking it for idiopathic hypersomnia. I love it, but am also fighting the insurance company. Funny how they have more power than the doctor. I also cut my directv, phone service and other things just to afford it. Let's hope for a generic soon!
Provigil loses its patent-protected status in 2012...Nuvigil is protected until sometime around 2023, I think. When generics for Provigil come out, they'll likely be nearly as expensive as Provigil until they recoup some of their costs.
Just started on Nuvigil literally today for residual hypersomnia from BiPAP-treated OSA. Depression hasn't been a major issue for me...situational depression a few years ago, but the constant sleepiness and exhaustion was surely taking its toll recently. I'm thankful that there's light at the end of the tunnel.
Scott
#12
Guest_swf_*
Posted 07 June 2010 - 11:43 AM
#13
Guest_Scott M_*
Posted 03 August 2010 - 03:58 PM
#14
Posted 04 August 2010 - 12:26 PM
Present Medications (in total daily dose)- Lithium Carbonate (600mg), Zyprexa (10mg), Suboxone Film (4mg), Efffexor XR (225mg), Concerta (54mg), Klonopin (1-2mg)
Attempts- Imipramine, Amitryptamine, Lexapro, Paxil, Risperdal, Trileptal, Lamictal, Cymbalta, Abilify, Wellbutrin, Seroquel, Adderall
Psychology- Weekly individual therapy, looking to change to new therapist soon!
I recently updated my "About Me" in my profile. If you want to know more about me, please read it.
#15
Posted 15 August 2010 - 02:51 PM
Also dumping ritalin after about 2 or 3 PM, not so late considering today I awoke at noon, after 12 hours sleep.
I added Nuvigil a little over two weeks ago and am noticing increasing pain, in hands, knees, feet, calves and toes. I am also very depressed and a bit paranoid. Has anyone else suffered these symptoms. I dropped the Nuvigil last night, I started it hoping it would extend the Vyvanse throughout the day, giving me more time of no depression, and it does do that. I am calling both docs tomorrow. My dose is 250 mgs a day, I started with 4 days of 1/4 pill, and 2 days of 1/2 pill. then whole pills. I need to decide if I should quite before paying for the whole next month and joining the program that does save $600 a year, seemed huge at first until I realized it was just a fraction of the monthly price!
I am tentatively very recently diagnosed with fibromyalgia and the pain is very bad until I get enough hydrocodone in me) , and now the top of 8 #10s I'm allowed is not really taking care of the pain as my doc thought it surely would. I've been tested for all the immune diseases, sleep clinic, everything, including Lyme, etc. The pain is getting worse and worse or so it seems, and the depression is back , I'm sure partly from no joy and an inability to join in..... most friends have given up on me over the years.. I have many which amazes me, but I now can no longer do the things we did together, and am mostly a hermit in house I cannot clean or keep up, have lot's of help outdoors, as I bought a ton of flowers for outside to celebrate 70 years and could not plant a one, as I was shortly thereafter hit wit the FM. I do think the FM after a year of stress and many losses threw me for a loop, and I would have been in a better place to tinker with this is it weren't for the unexpected pain and limited activity level (I'm very active mentally and physically being ADD of course) I still run free with ideas but my body won't accomplish a thing! My gram was driving back and forth across the country into her 80s and my Dad died accidentally or of suicide a year and a half ago. I lost my best dog, and my two new Whippets, yearling sister, have started to fight. I love them both and may likely have to give one up. The psychiatrist had just volunteered to sign them off as service dogs and I was so very happy. I have lurecoursed , a form of racing sighthouds, for 40 years, and while planned to retire my license this year, still planned to run these girl pups, super runners and frisbee dogs, and now it hurts just to take them to the field and throw for them. I do it anyway, of course.
I want to die, but I have two grown sons and I can't do it.. so I spend each day trying to make it to the next day. I'm told to walk, I hate it, so I'm also stubborn! I usually leave every winter for a few months and drive to AZ where I have friends, but now unless I get off some of the drugs that are making me dangerous at times on the road, I cannot leave northern
MN, where the sun does NOT shine many months. I am afraid, and no one wants to hear it, so I'm going to see if any of you know about Nuvigil, and try to go water my dumb flowers and take some to the dump now. They were scraggly leftovers, I'm not wasting good pansies, my favorites. I see as usual I have written much more than the rest of you. So I will call this my introduction and try to mark the important question about Nuvigil. thank you....
#16
Posted 15 August 2010 - 06:23 PM
to do, and my brilliant neuro, psych,pharm doc thinks. Between him saying 3 mgs of clonazepam is normal for me, and to keep up the ritalin, and her wanting me off the ritalin, off everything if possible (although the Vyvanse killed my depression for the first time in my life, I just chattered all the time like a squirrel:) I do not know what to think. I think CaptainYaaar
is right on to go to Nuvigil, and those comments and Tara's encourage me to hang with it.
#17
Guest_veryworried_*
Posted 07 November 2010 - 03:18 PM
#18
Guest_Cindy_*
Posted 17 November 2010 - 09:50 AM
I have as of lately been dealing with the kind of depression I am not used to. It has been hard to get and stay out of bed, its been difficult to take care of myself, and I cannot focus at all. I saw my pdoc about it. Initially I suggested Dexedrine because I had done very well on it before but we decided not to because I am prone to facial ticks and Dexedrine can mess with that. I asked him if there was anything similar to that and we decided on Nuvigil. I have been on it a couple days and have noticed a difference. (I dont make excuses to lie down anymore) I was curious if anybody else had any information or experience with this drug. I had never heard of it and I was curious about the affects ondepression, attention and focus. (Im starting college full time in a few days and Im concerned about my studies) Im also concerned about the impact on my anxiety, because I struggle with that (and Prozac has only kind of helped with that.)
Thanks in advance!
#19
Guest_CINDY_*
Posted 17 November 2010 - 09:54 AM
#20
Guest_Cindy_*
Posted 17 November 2010 - 09:56 AM
I have as of lately been dealing with the kind of depression I am not used to. It has been hard to get and stay out of bed, its been difficult to take care of myself, and I cannot focus at all. I saw my pdoc about it. Initially I suggested Dexedrine because I had done very well on it before but we decided not to because I am prone to facial ticks and Dexedrine can mess with that. I asked him if there was anything similar to that and we decided on Nuvigil. I have been on it a couple days and have noticed a difference. (I dont make excuses to lie down anymore) I was curious if anybody else had any information or experience with this drug. I had never heard of it and I was curious about the affects ondepression, attention and focus. (Im starting college full time in a few days and Im concerned about my studies) Im also concerned about the impact on my anxiety, because I struggle with that (and Prozac has only kind of helped with that.)
Thanks in advance!













