1. it's actually somewhat proven that it works for the "management of schizophrenia" i dont know the difference between a substance that is good for the "management of schizophrenia" and an antipsychotic.
The antipsychotics are two groups of medications that are routinely used directly against psychosis. The wikipedia definition prefaces that with "tranquilizer" but some of the atypical antipsychotics aren't supposed to be heavily sedating. The "major tranquilizers", like Haldol, achieve that by antagonizing dopamine receptors (blocking the triggers for dopamine release). The "atypical antipsychotics" are targeted more towards specific serotonin receptors, like 5HT2, which is thought to be the target for most hallucinogens.
l-theanine, even in massive doses, just isn't going to put a halt on a psychotic break or bring someone down from a bad trip like the APs. However, to the extent that glutamate plays a role in the process - either initiating the positive disease symptoms or by making things by damaging nerve cells through over-excitation - the results suggest that l-theanine may help slow things down or reduce the damage or both.
that doesn't directly address schizophrenia that suggests it's neuroprotective. Very recent work on l-theanine's known anxiolytic properties question whether it affects GABA the way a benzo would (link
) but at this point it seems that researchers are still trying to figure out how it manages to relax people.
2. if you want to get me in a fight i'm not into this kind of shit. go fight with occilatewidely or someone else.
You say that, and then you and OscillateWildly proceed to keep the fight going.
But if you two want to make me personally the target of the discussion, this topic can be locked too.
My biggest concern is how someone would know what an appropriate dosage would be given their size and medications they were on (and any possible interactions). I would think this is the kind of thing a doctor should be involved in prescribing.
l-theanine is available over the counter in the US as a dietary supplement, so a prescription isn't currently needed. The GRAS notice for a commercial l-theanine product notes that it's metabolized primarily in the kidneys, so liver enzyme interactions may be minimal.
As far as dosing goes, UPB mentioned the dose used in the study he's referring to. Drugs.com
notes that 200-250 mg has an anxiolytic effect, and that "Theanine is sold in the United States as a dietary supplement and has been granted GRAS status in doses up to 250 mg per serving by the FDA"
Edited by null0trooper, 07 July 2010 - 03:47 PM.