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Saphris


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#1 tylerismaximus

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Posted 06 August 2010 - 02:22 PM

started saphris sublingual tabs a couple weeks ago...just had to increase my dose again...has anyone else on here taken it with any results?
tylerismaximus

dx: bipolar I, ocd, anxiety, adhd,
current mood: unstable, depressed, suicidal, hallucinations
rx: geodon 160mg qd, trilifon 16mg qd, tegretol 400mg qd, prozac 80mg qd, valium 10mg tid, adderall 30mg tid
rx graveyard: abilify, risperdal, depakote, lamictal, saphris, lithium, cymbalta, zoloft, klonopin, adderall xr


#2 Aurochs

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Posted 06 August 2010 - 04:59 PM

Do you want specific information or just random input?

Saphris only reached market within the past year. Because there are a lot of other options in the list of AAPs that doctors are much more familiar with, they aren't likely to prescribe it very often, so you may not find a whole lot of other people posting here who've taken it. You may want to use the search function.

The Rx list in your sig says that you're taking both Geodon and Saphris. Why do you need two antipsychotics? If you have Bipolar I, why aren't you on a mood stabilizer?

Edited by Aurochs, 06 August 2010 - 05:01 PM.

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#3 AnneMarie

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Posted 06 August 2010 - 05:54 PM

I'm very curious about experience with Saphris as well. My pdoc brought it up as a possible swap for Risperdal that might eliminate need for any Seroquel regarding sleep issues. I'm apprehensive.

Bipolar I and ADD


#4 Gecko

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Posted 06 August 2010 - 06:10 PM

My Pdoc gave me Saphris when I was inpatient during a horrible episode of mania.
At first, I thought he was trying to kill me.
You place the medicine under your tongue and once there it explodes into the most God awfull taste you could ever imagine. And, you are not aloud to wash your mouth out or drink anything for awhile after you've taken it.

That aside, the stuff kicked my butt. It immediately began calming my mania and I was able to come to my senses. I stayed on 10 mg twice a day for about 4 months. It seemed to work well for me in controlling my mania and to be honest with you I should probably still be on it. I stopped taking it after the 4 month period due to some side effect issues. It made me crave carbs like mad, gain weight, blood sugar went up, horrible memory issues....pretty much the same effects I have when on Seroquel.

In my case it completely stabilized my mania and leveled me out but I just couldn't handle the side effects. And that God awful exploding in your mouth thing I mentioned above.
Finally properly diagnosed: acute, chronic PTSD, ADHD, Bipolar I Rapid Cycling, Generalized anxiety disorder and Migraine Headaches.
Current medications: 400 mg Lamictal, 200mg am and 200mg pm, 300 mg Wellbutrin, 10 mg Saphris, 1 mg Klonopin 3 times a day. Ampien CR at bedtime
Past medications: Seroquel, risperdal, lithium and abilify.

My Bipolar Blog

#5 Aurochs

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Posted 06 August 2010 - 06:54 PM

That's probably the biggest problem with Saphris - the sublingual route. It's really easy for someone to, say, spit it out, or drink water or something before it's all absorbed. Regular tablets don't work because of very low oral bioavailability. That said, the sublingual route does produce much faster results - peak concentration between 30 and 90 minutes after dosing.

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#6 llama44

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Posted 06 August 2010 - 07:06 PM

I was on saphris for a couple months as well. Words cannot describe the awful taste of that white little pill! Omg why can't they make it mint flavored?

Well I also had excellent results with it mood and psychosis wise but got off it due to side effects. It also made me sleep like a baby. I too should probably still be on it because of it's effectiveness on me. But it gave me the carb cravings right after I took it and I would eat probably thousands of calories until I passed out from the.tiredness that saphris produces. I gained thirty five lbs in around three months. It was horrible for my anorexic thoughts! Luckily I have lost twenty of those lbs by switching back to abilify. Thank goodness for abilify!
Diagnoses: Schizoaffective Bipolar Type ("Significant, Severe, Chronic, and Clear Cut"), Generalized Anxiety Disorder, Anorexia (in remission; dx in early teen years), OCD (dx in early teen years)

Current Meds: 600mg Seroquel, 30mg Abilify, 100mg Trazodone, 200mg Lamictal, 300mg Effexor XR, 3mg Klonopin.

Some days are better than others, but I do what I can.

How I'm doing now: I am down and am suicidal. I want to stay in bed forever. I never want to leave the apartment. The voices have been really bothering me. They also put thoughts in my head that aren't mine. They do this to torture me constantly. It is never silent.

#7 gizmo

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Posted 07 August 2010 - 10:43 PM

I'm afraid this will be pdocs next move if my zyprexa/risperdal combo doesn't work. I hope it works. I'm eating 1200 calories a day and losing maybe a pound a week right now... Hunger is intense. But I did find 100 calorie tuna salad kits, so I am eating lunch now, lol.
Diagnosis: BP I with Psychotic Features, GAD, ADHD, Chronic Migraines, various physical stuff.
Meds Currently On: Depakote 2000 mg, Risperdal 8 mg, Latuda 80 mg, Prozac 60 mg, Vyvanse 70 mg, Propranolol 40 mg BID, Klonopin 2 mg BID PRN
Meds Sort-Of Mental Related: Lipitor 40 mg, Zofran 4 mg PRN, Fioricet PRN, Stadol PRN, Botox received on 8/16/13

I post on an iPhone, so please forgive grammatical errors or strange word inclusions. It's the auto correct!

#8 Rabbit37

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Posted 23 September 2010 - 07:27 AM

I'm bumping this in the hopes that someone else will write of their experiences. I started it last night - Merck had the brilliant idea to make it black cherry flavored, I don't know if that helps at all. Anyway, had a bad case of akathesia, but finally with enough vistaril I was able to sleep. It's supposed to replace abilify, which is not only losing its effectiveness but apparently (according to pdoc) really messing up my cholesterol numbers. The official website states that it's really for mania and/or mixed episodes, but does it do anything for depression? That's my main problem right now.
dx - BP, OCD and BPD, oh yeah, and some GAD as well
rx - lithium, risperidone, citalopram, vistaril and vitamins

#9 llama44

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Posted 23 September 2010 - 02:39 PM

Black cherry flavored!??!!??! Why didn't they do that in the first place?!?! You should have tasted the stuff! LOL Sorry. I hope it works well for you. It worked very well for me. I miss the good sleep, less anxiety, less psychosis, less mania, etc. I may have to revert to it again in the future. We'll see. My pdoc still wants me on it.
Diagnoses: Schizoaffective Bipolar Type ("Significant, Severe, Chronic, and Clear Cut"), Generalized Anxiety Disorder, Anorexia (in remission; dx in early teen years), OCD (dx in early teen years)

Current Meds: 600mg Seroquel, 30mg Abilify, 100mg Trazodone, 200mg Lamictal, 300mg Effexor XR, 3mg Klonopin.

Some days are better than others, but I do what I can.

How I'm doing now: I am down and am suicidal. I want to stay in bed forever. I never want to leave the apartment. The voices have been really bothering me. They also put thoughts in my head that aren't mine. They do this to torture me constantly. It is never silent.

#10 AnneMarie

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Posted 23 September 2010 - 10:08 PM

I'm bumping this in the hopes that someone else will write of their experiences. I started it last night - Merck had the brilliant idea to make it black cherry flavored, I don't know if that helps at all. Anyway, had a bad case of akathesia, but finally with enough vistaril I was able to sleep. It's supposed to replace abilify, which is not only losing its effectiveness but apparently (according to pdoc) really messing up my cholesterol numbers. The official website states that it's really for mania and/or mixed episodes, but does it do anything for depression? That's my main problem right now.

FWIW, my pdoc says adecdotally it looks to help with depression.

Bipolar I and ADD


#11 OreoKitty

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Posted 26 September 2010 - 06:36 PM

I take 10mg of Saphris at night which puts me right to sleep. I just started 5mg in the morning due to high levels of irritability. I don't necessarily feel sleepy in the morning but my eyelids feel a little heavy. I'm pretty sure my pdoc is going to want to increase the morning dose to 10mg this week. And it has helped my irritability quite a bit.

Do other people have problems with the morning dose tiring them out?

Oreo

"Outside of a dog, a book is a man's best friend. Inside of a dog it's too dark to read."


DX: Bipolar I, hypothyroidism, PCOS, and food & various other issues and behaviors that fit into many forums
RX: Lithium 1200mg, Effexor 75mg, Wellbutrin 300mg, Latuda 80mg, Nuvigil 75mg, Valium PRN, Relpax, Synthroid 200mcg, Vitamins & Minerals
Past RX: ablilify, geodon, risperdal, neurontin, celexa, prozac, topomax, lamictal, seroquel, pristiq, valproic acid, tegretol, saphris, and others I cannot remember
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#12 Rabbit37

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Posted 26 September 2010 - 08:29 PM

I've only been on it a week, but yes, I have to take a morning nap. I assume that I simply haven't become adjusted to it, and hope with time that it'll dissipate, because I'm still on the 5mg/2x day, and expect that to be raised next week. Not looking forward to any more fatigue.

Oreo, the 10mg at night, was that initially both doses that you were taking together? I'm wondering if I can take them solely at night.
dx - BP, OCD and BPD, oh yeah, and some GAD as well
rx - lithium, risperidone, citalopram, vistaril and vitamins

#13 koali777

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Posted 26 September 2010 - 10:23 PM

I was on Saphris for a few weeks last January. I was only told to take 10 mg at night each day, even though everything else said to take it twice a day. For me, it didn't work. I was SO irritable on it and paranoid too. I had to take Cogentin with it as well because the akathesia was extreme. It did put me to sleep within 15 minutes though which was nice, and I slept through the night. Still my least favorite AAP though, second to Abilify.

My "Issues": Bipolar I with psychotic features; type 1 diabetes

 

My meds: Zyprexa- 10 mg twice daily; Lithium- 900 mg at night; Trileptal- 600 mg twice daily; Wellbutrin- 450 mg daily; Ritalin- 10 mg twice daily; Xanax- 0.25 mg PRN; insulin pump

 

Past antidepressants: Celexa, Zoloft, Lexapro, Pristiq, Nortriptyline, Wellbutrin SR

Past antipsychotics: Risperdal, Abilify, Seroquel, Geodon, Saphris, Latuda, Invega

Past anti-anxiety meds: Klonopin, Vistaril

Past ADD meds: Vyvanse, Strattera, Adderall XR, Adderall IR

Past sleep meds: Rozerem, Benadryl, Ambien, Restoril, Trazodone

 

 


#14 OreoKitty

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Posted 27 September 2010 - 06:02 AM

Oreo, the 10mg at night, was that initially both doses that you were taking together? I'm wondering if I can take them solely at night.


First I took 5mg at night for a few days, then 10mg every night. A couple weeks later pdoc added 5mg in the am because of my extreme irritability, which it did help.
I've read that suggested dosages are 10mg/BID. I'm wondering if I can talk him into 5mg in am and 15mg at night because I don't want to be sleepy in the morning.
Oreo

"Outside of a dog, a book is a man's best friend. Inside of a dog it's too dark to read."


DX: Bipolar I, hypothyroidism, PCOS, and food & various other issues and behaviors that fit into many forums
RX: Lithium 1200mg, Effexor 75mg, Wellbutrin 300mg, Latuda 80mg, Nuvigil 75mg, Valium PRN, Relpax, Synthroid 200mcg, Vitamins & Minerals
Past RX: ablilify, geodon, risperdal, neurontin, celexa, prozac, topomax, lamictal, seroquel, pristiq, valproic acid, tegretol, saphris, and others I cannot remember
Sober since 1992


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#15 mj1127

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Posted 27 September 2010 - 07:30 PM

I took it for about two weeks for intractable depression. I think it's possible it was doing something until I got EPS and had to stop. I'm glad to hear they've done something about the taste (if it's an improvement) - the unflavored one I took was absolutely terrible.
MJ
dx: Bipolar NOS, ADHD, migraine
Rx: Lithium CR 1200mg, Wellbutrin 225mg, Abilify 5mg
, Latuda 20mg, Adderall 20mg BID, Xanax XR .125mg BID
Past Rx: Depakote, Lamictal, Neurontin, Tegretol, Invega, Saphris, Zyprexa,
BuSpar, Dalmane, Klonopin, Adderall XR, Concerta, Ritalin, Ritalin SR, Vyvanse, Anafranil, Elavil, Tofranil, Celexa, Lexapro, Paxil, Prozac, Zoloft, Remeron, Wellbutrin SR, Corgard, Inderal, Ambien, Lunesta, Sonata, probably others

#16 Guest_therern_*

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Posted 29 September 2010 - 09:46 AM

I'm bumping this in the hopes that someone else will write of their experiences. I started it last night - Merck had the brilliant idea to make it black cherry flavored, I don't know if that helps at all. Anyway, had a bad case of akathesia, but finally with enough vistaril I was able to sleep. It's supposed to replace abilify, which is not only losing its effectiveness but apparently (according to pdoc) really messing up my cholesterol numbers. The official website states that it's really for mania and/or mixed episodes, but does it do anything for depression? That's my main problem right now.



#17 Guest_donna l._*

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Posted 30 September 2010 - 10:37 AM

started saphris sublingual tabs a couple weeks ago...just had to increase my dose again...has anyone else on here taken it with any results?

Been on it for awhile. Seems to be working at least to a point. Have to have the black cherry ones. Can't handle the others. Federal prescription company says they can't get but Walmarts can. My son takes this also. Gets into the system immediately. Great alternative for those of us who have had gastric by-pass surgery.

#18 tylerismaximus

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Posted 30 September 2010 - 10:55 AM

i had no idea it came in black cherry....ive been gagging on the normal ones every night....but i get free samples from my pdoc so i have to take what i can get with no insurance.....this has worked very well so far to stabilize my mania....no side effects to speak of
tylerismaximus

dx: bipolar I, ocd, anxiety, adhd,
current mood: unstable, depressed, suicidal, hallucinations
rx: geodon 160mg qd, trilifon 16mg qd, tegretol 400mg qd, prozac 80mg qd, valium 10mg tid, adderall 30mg tid
rx graveyard: abilify, risperdal, depakote, lamictal, saphris, lithium, cymbalta, zoloft, klonopin, adderall xr

#19 Rabbit37

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Posted 30 September 2010 - 12:10 PM

The black cherry ones I have are samples too, so you might ask your pdoc to ask your pharm rep about that? Apparently it's brand new.
dx - BP, OCD and BPD, oh yeah, and some GAD as well
rx - lithium, risperidone, citalopram, vistaril and vitamins

#20 tylerismaximus

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Posted 30 September 2010 - 12:26 PM

good to know thanks
tylerismaximus

dx: bipolar I, ocd, anxiety, adhd,
current mood: unstable, depressed, suicidal, hallucinations
rx: geodon 160mg qd, trilifon 16mg qd, tegretol 400mg qd, prozac 80mg qd, valium 10mg tid, adderall 30mg tid
rx graveyard: abilify, risperdal, depakote, lamictal, saphris, lithium, cymbalta, zoloft, klonopin, adderall xr





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