Increased sex drive with Seroquel XR
Posted 27 January 2011 - 02:18 PM
Is it even possible that it's down to the meds themselves? Should I be watching for further signs of mania?
"Don't for one second feel ashamed of those scars on your chest. You're just wearing on the outside what the rest of us wear on the inside."
- Sean MacNamara, Nip/Tuck
Slartibartfast: "Science has done some amazing things, but I'd far rather be happy than right any day."
Arthur: "And are you?"
Slartibartfast: "No. That's where it all falls down, of course."
"This must be Thursday. I could never get the hang of Thursdays."
- Arthur Dent
Posted 27 January 2011 - 03:01 PM
it is quite the opposite for me
I hope you have a partner with whom to enjoy yourself
'Mania is a dangerous Mistress.' BPLadybug
Treatment: 900 mgs Lithium, 900 mgs Neurontin, 400 mgs Seroquel, Xanax prn, Temazepam, fish oil, vitamins, Vit. D 5, 000 IU, exercize, some talk therapy and CBT Therapy. Exercize helps as does the Light Box; 30 mins every morning. I also have physical health challenges.
Posted 28 January 2011 - 06:15 AM
it says on wikipedia, that seroquel is a weak dopamine antagonist and one of it's metabolites is a strong noradrenergic reuptake inhibitor, which has aphrodisiac effects. maybe these properties are attributed to the increased sex drive. also, the remeron you take is another pro-sexual drug. it blocks serotonin type 2C receptors, which cause increased levels of dopamine and noradrenaline in the brain.
RX: Seroquel XR (quetiapine) 400 mg / daily, Anafranil (clomipramine) 50 mg twice daily
Posted 29 January 2011 - 11:29 AM
I should just stop here.
it says on wikipedia
At 400 mg, quetiapine has enough dopamine receptors blocked to be an effective antipsychotic. No antipsychotic is effective as an aphrodisiac, which kinda blows that theory out of the water. The OP was only taking 100 mg at the time of the post, which is not so effective as an antipsychotic, but that would also lessen any other effects.
that seroquel is a weak dopamine antagonist and one of it's metabolites is a strong noradrenergic reuptake inhibitor, which has aphrodisiac effects. maybe these properties are attributed to the increased sex drive. also, the remeron you take is another pro-sexual drug. it blocks serotonin type 2C receptors, which cause increased levels of dopamine and noradrenaline in the brain.
I have never heard of norepinephrine reuptake inhibition being the cause of increased sex drive. Strattera, for instance, doesn't make people horny (it sure as hell didn't do that to me). Even if it was, both quetiapine and N-desalkylquetiapine are also alpha blockers.ref Further, no information is available about the proportion of N-desalkylquetiapine compared to other metabolites and the parent drug in plasma. I find this argument hard to swallow.
The OP has been taking Remeron for quite some time, but only noticed the increased sex drive after starting Seroquel.
The OP was depressed and wasn't sleeping well before he started on the Seroquel. These are two factors that I know reduce sex drive. I'm inclined to go with his first theory, that finally getting some good-quality sleep is what made him bounce back. If he's also feeling better in other areas, then he may well be recovering from depression.
Edited by Aurochs, 29 January 2011 - 11:30 AM.