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Check those charts out, they are really intersting. From Ian Chovil's schizophrenia site. Thanx Ian!
Relative receptor occupancy rates for Atypicals
D2 and 5h2T Occupancy (with antipsychotic threshold and EPS threshold doses)
Chemical activity of antipsychotisc
PBF
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Check out these charts about atypicals
Scientific info about APs - interesting
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#2
- Shouting at the monkeys in the next tree
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Posted 05 March 2007 - 12:56 PM
Jeez, Olanzapine's pretty much a scatter gun, isn't it? Hit everything just in case...
Officially no longer Mixed Bipolar NOS. However, I do still have AP/D, and Alice In Wonderland Syndrome (OK, OK, so it's migraine without the headache, and really rather funky). Oh and I also have synesthesia. And most likely Alexithymia, but that's another story.
Alexithymia!
Rx: Surmontil 50mg (terminal insomnia)
Previous Rx's: Lamictal 200mg, Zyprexa 10mg, Xanax .25mg prn, Elavil 50mg, Imovane 5mg, Prozac 20mg, Cipramil 10mg, Cipramil 20mg, Cipralex 10mg, Cipralex 5mg (not all at the same time, obviously).
Alexithymia!
Rx: Surmontil 50mg (terminal insomnia)
Previous Rx's: Lamictal 200mg, Zyprexa 10mg, Xanax .25mg prn, Elavil 50mg, Imovane 5mg, Prozac 20mg, Cipramil 10mg, Cipramil 20mg, Cipralex 10mg, Cipralex 5mg (not all at the same time, obviously).
#3
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Posted 05 March 2007 - 01:30 PM
Most Coool! Easy to understand charts. Even with a biology degree I find the pharmacology tough going, and mostly boring, but these are simple to understand.
I was going to say the same thing about these meds 'shotgunning' receptors. We are no longer in the "stone age" of psych meds, but clearly the future holds the promise of more better targeted drugs with attendant lower side effects.
a.m.
I was going to say the same thing about these meds 'shotgunning' receptors. We are no longer in the "stone age" of psych meds, but clearly the future holds the promise of more better targeted drugs with attendant lower side effects.
a.m.
** I am NOT a doctor or medical professional, just a lapsed biologist. Don't construe anything I say as medical advice. Consult your physician. **
dx: BPI, ADHD (inattentive), (anxiety), hypothyroid, severe sleep apnea, asthma, allergies, *New* Essential Tremor
Previous dx: BPII, depression
rx: 900mg Eskalith, Strattera 100mg, Cymbalta 60mg, 7.5mg Adderal, 25mg metoprolol prn, 112.5mcg Synthroid, Xanax XR 1mg prn
Keeping CrazyBoards Strong For Its Members.
dx: BPI, ADHD (inattentive), (anxiety), hypothyroid, severe sleep apnea, asthma, allergies, *New* Essential Tremor
Previous dx: BPII, depression
rx: 900mg Eskalith, Strattera 100mg, Cymbalta 60mg, 7.5mg Adderal, 25mg metoprolol prn, 112.5mcg Synthroid, Xanax XR 1mg prn
Keeping CrazyBoards Strong For Its Members.
#4
- Too many answers, not enough questions.
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Posted 07 March 2007 - 12:22 AM
I wouldn't be bashing Zyprexa (or Risperdal, for that matter) because they both gun in different places.
The new hawtness in AD treatment is agomelatine (Valdoxan in Europe), which blocks the 5HT2 receptor (I forget which subtype/s, but I do know that Risperdal only will block the 5HT2C receptor). The other end of the agomelatine molecule, interestingly, activates the MT1 and MT2 melatonin receptors... it's supposed to regulate sleep cycle.
In any event, there are researchers here and there speculating that 5HT2 is responsible for some portions of psychosis (namely hallucinations). Specifically, I'd guess 5HT2A... only since I've read that psilocybin (the active ingredient in magic 'shrooms) and LSD are powerful activators of it... I do understand they both cause visual interestingness.
The new hawtness in AD treatment is agomelatine (Valdoxan in Europe), which blocks the 5HT2 receptor (I forget which subtype/s, but I do know that Risperdal only will block the 5HT2C receptor). The other end of the agomelatine molecule, interestingly, activates the MT1 and MT2 melatonin receptors... it's supposed to regulate sleep cycle.
In any event, there are researchers here and there speculating that 5HT2 is responsible for some portions of psychosis (namely hallucinations). Specifically, I'd guess 5HT2A... only since I've read that psilocybin (the active ingredient in magic 'shrooms) and LSD are powerful activators of it... I do understand they both cause visual interestingness.
Me: MDD, AD/HD, Aspie/HFA/PDD-NOS/WTF, REM behavioral disorder/misc. sleep issues, systemic infection involving mostly the brain and lungs w/Parkinsonian syndrome and chronic bronchitis respectively... and if that weren't enough, I have prolonged and repeated PTSD, with continuing emotional trauma at the moment. Genetically inherited Kallmann's syndrome (KS/IHH) explaining some of the aforementioned.
Meds (in flux): Lamictal, Cymbalta, Remeron, Synthroid, methylphenidate-ER, penicillin-derivative antibiotic du jour, clonazepam.
"Using this drug to treat schizophrenia is like attempting to treat asthma with Zyklon-B." -- From an RXList.com patient review of a certain typical antipsychotic.
Meds (in flux): Lamictal, Cymbalta, Remeron, Synthroid, methylphenidate-ER, penicillin-derivative antibiotic du jour, clonazepam.
"Using this drug to treat schizophrenia is like attempting to treat asthma with Zyklon-B." -- From an RXList.com patient review of a certain typical antipsychotic.
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