Has anyone tried taking Tyrosine to counteract sleepiness/tiredness?
i take it along with some other things for brain fog/ depression/ Chronic Fatigue.
I have a strong suspicion, after many many drug trials, that part of my depression is due to a low level of norephinephrine. I think this because Sudafed, and other less legal substances that stimulate production of norephinephrine, work well to keep me from feeling tired, but SNRI's don't. The logical conclusion seems to be that my brain doesn't make enough -- blocking re-uptake doesn't work because there's not enough there to make a difference, re-uptake or not.
i have no idea about the science behind this. I had my amino acid levels tested and i was extremely low on phenylalanine, which the body turns into L-Tyrosine. I have felt better since taking it, but I also take other supplements so I can not attribute all my feeling better to Tyrosine.
So -- a couple of early studies showed that large doses of Tyrosine worked for people who needed stimulants (i.e., dexadrine) to treat their depression. The dosage was 100mg/kg/day -- so for a 150-lb person it would be something like 6 grams a day. Apparently this is safe.
I'm just curious if anyone has tried this. I'm contemplating it.
I think the dosage level you're speaking of is the guideline used for people who suffer from PKU (Phenylketonuria) which is a rare genetic problem where people can not process phenlalanine, and consequently end up with very reduced levels of L-Tyrosine. In someone not suffering from PKU, taking this much L-Tyrosine is dangerous.
I take 500mg twice a day on an empty stomache. This is actually considered a high dose, and there aren't studies on the long term effects of even this level of dosage. If you decide to take it, please try starting with a low dose, see how you feel, and slowly increase to no more than 1000mgs a day.
I could not find any information about interactions between Tyrosine and SNRIs, and checking with your doctor before adding any supplement is always wise. I have read that people on stimulants for ADD may need Tyrosine supplementation if their blood levels are low to help make the medication effective, but I couldn't find anything on SNRIs.
To aid in the conversion of Tyrosine into neurotransmitters, many reccomend that you take B6, Folic Acid and Copper (all of which can be provided by taking a multi.)But, please, check with your doctor about any possible interactions before you start taking L-Tyrosine.