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  1. I've switched from Luvox to Lexapro without any problems. No withdrawal from the fluvoxamine at all and escitalopram kicked in after 3 weeks. Don't think that swapping between SSRI's is a common issue, but there's not a guarantee that the new SSRI will have the same effect or will help you like the old one did. So if the new one doesn't work, don't hesitate to tell your doctor and try another SSRI or even SNRI.
  2. Hi, I was in the same boat twice. I was on Luvox, which I restarted a couple of times over a period of 2/3 years. With my third restart is didn't work anymore. I switched over to Lexapro (escitalopram) and had much succes with it. I was on it for about 6 years (varying dosages, but I was on 5 mg for the last 2 years). At first I thought I stopped working all of a sudden, but later I realized I was having some withdrawal symptoms in the two/three months before the "AD-poop out". My gdoc advised me to taper the escitalopram and I was med-free for about 4 months. This January I started with Zoloft. I'm almost at 200 mg, but I'm sorry to say that this switch wasn't a big success. I don't experience much side effects (restless legs and ringing ears before bed), but I still have intrusive thoughts. I feel less depressed though, so maybe it is working for low moods! I do agree with Mik though...if I were you I would ask for either Zoloft or Prozac. Luvox would be fine as well, but Zoloft has a better side effect profile. Evaluate the new AD after 4/6 weeks. I know this seems like a long time, but you can switch without having to taper down (or you can do a cross taper).
  3. Hey all, So I've been on Zoloft for almost three months. Not convinced about the effect. Today as well as yesterday weren't good days and I have these kind of days regularly. I have intrusive thoughts all the time and I can't concentrate. When I'm around people and my attention is turned outward I can function a lot better. Maybe this is due to Zoloft's affinity for dopamine...I don't know, but I rather be among people right now than sitting alone working behind my computer (I have my own graphic design business so I don't have much choice). I'm on 175 mg of Zoloft. I increased the dose a week ago. It seemed to kick in at 150 mg but after a few days of feeling quite OK with less intrusive thoughts the feeling went away. The same happened with 175 mg. I really don't want to wait for 3/4 weeks anymore with trying out higher dosages. I'm going to ask my gdoc if I can up to 200 mg next week and try this for a few weeks. I'm thinking about Anafranil and when I was reading up on switching from Zoloft to Anafranil I also read that TCA's can be used to augment SSRI's. Zoloft and Anafranil aren't an uncommon combination. I feel like the Zoloft is partially working. Maybe this augment strategy is something for me? The side effects I have from Zoloft are: restless legs (but I can still sleep, I just wake up early) and mild tinnitus before going to bed. I wonder if I would rather have more side effects and less intrusive thoughts....
  4. So I've been on Sertraline for 8 weeks...150 mg for almost 2 weeks. It's not doing what I hoped it would do for me. On some days the intrusive thoughts are less and I can concentrate better. On other days they keep intruding. My experience with Luvox was the opposite really! The only side effect I'm having are restless legs, which I'm quite familiar with (had it with Luvox too). Other side effects are gone though when I'm having a stressful day I feel these (slightly annoying) twitches in my legs and sometimes in my arms. I still wonder what my chances are with Luvox. Or when I should increase my dose. My general doctor would be against that but I just really want to know if sertraline is the SSRI for me. I'm getting so impatient that I'd rather give up next week and try Anafranil because it should be stronger and I read some much good things about it.
  5. I think I've been on 100 mg for about 4 weeks. In my experience an increase of dose can take up to a full month to have any effect, so that similar to your experience with the 150 mg. Hopefully it will kick in at this dose...otherwise I have to get back to my gdoc, beg him for raising my dose and then wait another 4 weeks to see if 200 mg has any effect. It just takes so long! I think I'm also kind of anxious that this med won't work and that my long use of escitalopram caused this. I've read too much about receptor down regulation and changes that SSRI's make to the brain. In my darkest thoughts the Lexapro is the cullprit causing insensitivy to the working mechanism of SSRI's and now no other SSRI will help me.... Doubting everything is part of OCD I guess ;-)
  6. My third day on 150 mg of Zoloft. I take it before bed and an aching stomach woke me up the next morning. I felt some pressure on my esophagus and swallowing was uncomfortable. Fortunately it got better the next day. I'm almost sure this was from the Zoloft. Yesterday was a good day, with less intrusive thoughts, but today sucks again. Thinking unwanted thougths constantly. Maybe it's from increasing my dose. I'll have to wait it out. It's just so different from Luvox...with 9 weeks on it I never felt better! Now I'm taking Zoloft for 7 weeks and I don't feel confident at all.
  7. Thanks I'll have to keep this in mind!! So before switching, I'll have to titrate down the sertraline first to the equivalence of the starting dose of Prozac? For now I'm going up to 150 mg. My general doctor finally raised my prescription. I'm getting 50 mg tablets so if all goes well and I don't feel any effect I might increase to 200 mg myself. I know my gdoc won't be happy but in the mean time I'll look for a pdoc. If he/she says I need to go up to 200 mg or even higher my general doctor would probably go along with it. Even my counselor and psychologist said: "It's your body and taking these medications is your own decision. We'll support you whatever you do". I think my gdoc just doesn't get that I've been dealing with these intrusive thoughts for 12 years. I know what helped me and I know what didn't. Hey 300.3 how are you? So you don't feel much effect from the lamotrigine just yet? Do you have any side effects?
  8. Thanks Mik. I'll keep in mind the Prozac. I know it has a very long half life and I'm curious if this will benefit me. The mornings are the hardest for me because the unwanted / intrusive thought starts rights after I wake up. Maybe a med with a long half life can help with that. I've been on Lexapro 20 mg as the highest dose. I didn't know it was safe to go any higher. I've read that there are people going up to 30. If you can take the side effects, why not? When I increased my dose of Lexapro to 15 mg last Spring I had far more side effects than before, so that's why I didn't stick with it. And of course it didn't help me at all. Zoloft only slightly upsets my stomach. I always felt lucky on Lexapro and Luvox because side effects were tolerable. Zoloft's side effects are even milder!
  9. Hi Gearhead, I don't know. I get the impression that the OCD board isn't as active as the Antidepressants board and my questions are mainly about what antidepressant I could try next. It seems to me it's more about meds than OCD symptoms.
  10. No I haven't tried Prozac, ever. The pdoc I've consulted this January said that Zoloft was a good choice, but Prozac was fine if I wanted to try that instead. I've been on Luvox for about two years. I was on 100 mg on a certain point but after a while I lowered to 50 mg. After about 6 months I went off it because I felt like I didn't need it anymore (didn't know much about these kind of meds back then) When I relapsed I started Luvox again and went up to 200 mg. It worked fine for quit some time and after a year or so I could wean myself off. After a few months the intrusive thoughts came back, so I went back to my doctor and I was put on 150 mg of Luvox. If I recall correctly I went up to 200 mg, but after 9 weeks I gave up and went back to my general doctor. This was 7 years ago. Then I got on Lexapro, 10 mg and that worked after about 3 weeks
  11. Thanks Mik! Nice detailed descriptions! I knew a bit of the differences of SSRI's but didn't put much significance to them concerning efficacy. Maybe this is why Zoloft isn't working quite as good. Luvox was my first SSRI and although it didn't do much the first 4/5 weeks, it really kicked in after that. The intrusive thoughts just vanished! With Lexapro the response was much faster (with only 3 weeks) BUT after 2 months it seemed not to work as good, so dose was increased to 20. The first two years on Lexapro weren't nearly as stable as my time on Luvox. I would love to try Luvox again, but since it did poop out... It has been 7 years....and side effects were tolerable. I wonder if it could work again.
  12. I guess these waiting periods are the hardest for me. I don't trust my own brain anymore. Though my variation of OCD is more obsessive (with just unwanted thoughts and no compulsions) I still have a hard time dealing with uncertainties. I'm always coming up with 'Plan B's' and adding Lamicital is in fact a Plan B. In spite of all the therapy I already had I still feel like I need a Plan B to stay calm. Like: "There's always something to try if this doesn't work". I need that reassurance. Maybe that's my compulsion. In theory, all SSRI's work the same, but just with different side effects. I wonder how it's possible that one SSRI works for a person, but another SSRI doesn't. In my case, I have been on Luvox for some time and then on Lexapro for like 6-8 years. Lexapro suddenly stopped working (my unwanted thoughts came back out of the blue) and increasing dose didn't do anything. Why was this and did this cause Zoloft to be less effective or giving me no effect at all? (Yes, I'm overthinking this, but it's interesting matter still)
  13. Hey Mik, thanks for the interesting feedback on clomipramine I've always thought that if one SSRI works, then all others should work as well (but with different side effects) and I wouldn't have need for a less selective drug like Anafranil. Maybe I won't need it...I'll have to figure out what a higher dose of Zoloft is like first. I've been on 20 mg of Lexapro as well, it was quite effective! I've read a lot about memantine. The pdoc Ive spoken to in January said it was an 'exotic' option. He wasn't really willing to prescribe it because I've never tried other antidepressants...But even if I could try it my insurance doesn't cover it because it's off label. It would cost me €3 to €5 per day! Maybe Lamicital could be a possibility but my gdoc would never think outside the I would definetly need a gdoc to discuss the glutamergic ideas.
  14. Thanks Redhead for your feedback on the Anafranil! I think if I had to choose a new treatment and my choices would be between Anafranil and Prozac I would go for Prozac first. But I guess Anafranil is a better choice than Abilify as a mono therapy. So if I had to choose...And antipsychotics are completely new to me as well... From what I understand an AP more commonly used to augment an SSRI is Seroquel or even Haldol but I'm not willing to take that route just yet. Tomorrow I'm at the sixth week mark so hopefully my gdoc will just listen to me and have at least try out the maxinum dose.
  15. Thanks for sharing! I thought Zoloft was the most activating / stimulating. It has more dopamine affinity than other SSRI's. At my current dose I don't seem to have any issues with feeling more active or anxious and my sleep is fine. With Luvox and Lexapro I didnt have much problems either, side effects I had were restless legs and teeth grinding. I have no idea if this means anything. But I'm much more scared of going on Anafranil than Prozac! I wonder if Abilify could be something to add. When I was on Lexapro I was feeling quite sluggish and unmotivated in the mornings. Now the same with 100 mg Zoloft. Oh and I' ll ask my gdoc for a referal to see a pdoc. I don't have much faith in just my gdoc handeling my medication. Even my counsellor agreed that 100 mg isn't much (he worked in the psychiatric field for years)