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  1. Well, a poop-out is considered when the drug (most of the time it's an SSRI) stops working. It can happen all of a sudden, but if I recall correctly from studies it happens more gradually most of the time. This is what most people report on forums as well. The anti-depressant effect wears off and people report that they think the med isn't doing what it is supposed to do. They have more depressive thoughts and feelings or notice strange symptoms in their body (which are later seen as symptoms of withdrawal). People with intrusive thoughts and obsessive behaviors notice a (sudden) increase or start to feel anxious again. I'm not sure if you experience poop-out (tachyphylaxis). I've read alot about this topic, since two SSRI's pooped-out on me in the past, and haven't come across anything similar to your story.
  2. Hey, thanks for replying! It started 13/14 years. I had a panic attack when I was alone in my bedroom. I was going through some tough times with work and was extremely tired. From childhood I've been scared of dying. Not right away, but really the knowledge that this is going to happen some day. You could call it a phobia, but in daily life I wasn't scared of death at all. I wasn't avoiding funerals or agoraphobic.. It caused a panic attack once in a while, but only just before sleeping. The dark and the silence could trigger an attack of anxiety. I'm an atheist and I've always been afraid of the 'emptiness' and later the thought that a person just isn't 'there' anymore. Dissapearing, that was the thing of death that scared me most. The day it started I had such an attack, but I knew how to calm myself down. This time though, the word 'death' didn't leave my mind. The fact that I couldn't stop thinking the word (and not the concept of death itsself) worried me. I didn't know what was going on and felt ashamed, having this bizarre thing in my mind all day. It comes close to an earworm or stuck song indeed. The word 'death' doesn't trigger loads of disturbing thoughts, no. It does cause me to ruminate a lot. Again, not about death, but about why this word got stuck and how to get rid of it. I think this is a huge part of its persistance. I have to admit that I have had 'silly words' or unusual names getting stuck before, just for a while. I don't think much of these words, they aren't disturbing and go away on their own. No, I don't have Asperger or any other form of autism. I think, apart from the 'stuck word syndrome' I'm a very average ;-) I've tried hypnosis. About 11/12 years ago. I've had about 12 sessions. In hind sight I'm not sure if the hypnotherapist knew how to handle it, but she was a professional. Every time the session ended I hoped the thought was gone and I was always dissapointed because it wasn't. I'm not sure if should give it another try. I actually hope Prozac might be it....but it's not really a long term solution.
  3. Hi all, I've been thinking....lately it's going OK. I haven't seen my general doctor for about two months and I'm still on Zoloft (I dropped to 50 mg). I can manage. There have been good days, when I feel normal and enjoy the little things. These good days are days when the intrusive thought isn't so 'loud' and frequent. I don't feel depressed in general. The stress caused by the crisis in my family is a lot less, though it's not entirely over, because new lawsuits are being filed. But, I do believe I can handle things better. I've been on a vacation with lots of sunshine and distraction and I feel much more rested. But....the intrusive word in my mind still keeps bugging me, every day. It made its comeback in May 2016 and I still haven't managed to not feel agitated or frustrated about it. It's getting my attention. I tried all kinds of therapy (including mindfulness and meditation), but I suspect that it is a mixture of obsessing over it, brain chemistry and genetics. Most people with Pure O feel anxious and they are afraid they will act on their thoughts or they think these thoughts are theirs. There are techniques available to learn how to tolerate these thoughts. I'm not scared of my 'stuck word'. It is just incredibly annoying. It bothers me when I'm working, talking to someone, petting my dog, etc. When it appears in my mind I feel agitated. "You again?" but not with so many words. Some days it will enter my mind 1 minute after waking up. The next day after 5 minutes. It irritates me. I wish I could stop that. It's just a thought. I think it can be compared to body focused obsessions (like breathing-ocd or eyeblinking-ocd). Okay, so the first two SSRI's helped me incredibly. Until they pooped out. Zoloft only seems to work on some days. Or maybe I'm doing it all on my own.... You guys might remember that I've been considering Anafranil and Prozac as well. Or going back to Luvox (it's been 10 years since it pooped out). Anafranil / clomipramine: my main concern are the expected side effects. And, is this drug really necessary? I've read lots of success stories from people with refractory OCD. But it's only a bothersome, persistent thought.... Prozac/Fluoxetine: It's an SSRI and I'm kind of afraid that Lexapro, my previous SSRI, messed things up and that is why Zoloft doesn't do the trick (The same worry for Luvox / fluvoxamine). I feel like a could use something really specific, which will help me stop feeling agitated, annoyed or frustrated when the intrusive word pops up in my mind. Is there an antidepressant which does something like that? I know anti-psychotics are being used because agitation is a symptom with schizophrenic and psychotic disorders, but I'm not sure were talking about the same kind of agitation.
  4. I don't have the typical Pure O obsessions. But I do have a word stuck in my mind and I obsess over getting rid of it. It has been the same single word for about 13 years, though it has been gone for about 6 years when I was taking an SSRI.
  5. Lexapro 10 mg is a moderate dose. Lower than that isn't therapeutic for most people (though it seems to be for panic and some anxiety disorders). I'm not a doctor though. Schizoaffective disorders are usually difficult to treat (or recognized to begin with) since the symptoms are so mixed.
  6. Hi there, between 50 and 125 mg is a therapeutic dose of sertraline for depression (effect on ocd can ask for a higher dosage). It can take up to 8 weeks. Some people do feel the effect after only two weeks (or experience a placebo effect), but another SSRI, escitalopram, is actually the only one out of the bunch which is known to kick in earlier (2-3weeks). With other words: You should give sertraline some more time ;-)
  7. I took Lexapro after Luvox (see signature for more detail) Both great meds, both pooped-out. I held out on escitalopram for about 5 years and it kicked in quite fast. I was really happy with this med, because it helped me getting rid of the intrusive word/thought completely. The drawback was that it made me sluggish. I didn't have the motivation to get dressed in the morning and waking up and getting ready to start my day always took a few hours. I didn't feel tired. Just...kind of lazy. On higher dosages I had restless legs (I think this has to do with the serotonin inhibition) and very vivid dreams. O, and some teeth grinding. When I went down with my daily dose these side effects weren't really that noticable.
  8. Combining two SSRI's is kind of rare....unless you're cross tapering. Paroxetine is touching more receptors than fluoxetine and I think the serotonin inhibition of the paroxetine and the fluoxetine might be too much for you. It could -in theory- cause serotonin syndrome when you take 40 mg and paroxetine (maximum dose is 60 mg per day I think?) together. I do not think that psychosis is a symptom of serotonin syndrome, but I'm not a doctor either. Have you asked your pdoc?
  9. Some Longcity forummembers have experience with tianeptine (also known as Stablon or Coaxil). There used to be a few threads about this anti-depressant. You might want to check out the forums over there. It's not an SSRI, like jt07 already said, but some also call it an 'SSRE', a selective serotonin reuptake enhancer. I don't know if this is entirely correct though, since mentions that it "produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity". It's not available in my country, but I always find it interesting to read more about it.
  10. Thanks! I'm curious too! My current gdoc (so not the new one) comes back from his vacation on the 14th of this month and every other day I consider going to see him for one last plea to switch me to another anti-depressant. I'm getting soooo tired of this going up and down... One day it feels like the Zoloft is really helping me, when I'm around people, talking and the topic really interests me. Last Thursday was an extremely exciting day and I felt really tense. In the evening I realised I hadn't had that annoying thought in my head all day! Of course it started bothering me that the thought came back, but I managed to tolerate it because during the day I was focused on the main topic. So my mind was busy, but not in an anxious way. I didn't feel high strung, quite strong actually. A few days later, like today, I don't think that Zoloft is working at all. Constantly the thought in my head wich bothers me (it's been the same for more than 13 years) and I still don't understand why I can't just forget about it. All thoughts come and go, but this one got stuck and I don't like it. I can't stop noticing it. It's almost like a body-focussed obsession (like breathing ocd). I know the brain likes playing these kind of tricks on people, but after years of therapy I finally found something which worked (Luvox) and 10 years on medication and STILL I'm not done with having that stupid thought in my head. ARGH!! Stupid brain, stupid Zoloft, stupid me! Sorry, just frustrated....
  11. Thanks for the feedback! I'm still not sure what I will do next, but I'm switching general doctors upcoming September. I wonder what she (my new gdoc) will say and I really hope she'll let me see a pdoc, so I can discuss all the ideas I've gathered in the last few months (with much help from you guys!! ). She would probably prescribe Anafranil without the consultation of a pdoc (because he already recommended it to me last January) or she will let me go on Luvox because I have positive experience with it. I think it will work out
  12. I think so too. I never felt sedated or groggy on fluvoxamine (Luvox). Escitalopram (Lexapro) made me feel less motivated and a little sluggish, but never sedated. Sertraline (Zoloft) is said to be activating and can cause sleep problems (even insomnia) But apart from the restless legs (which I had will al three SSRI's) I'm sleeping fine.
  13. I have one intrusive thought (the same one as 13 years ago) and I was free of this thought for about 2 years on Luvox and 5/6 years on Lexapro. Though with Lexapro it wasn't as stable. Zoloft only partially works. I find that I can work behind my computer, drive my car, have conversations, play games, talk with customers, etc and still have the thought popping up. Although this is annoying, I'm used to it and I don't get anxious at all. Lately I've been worrying and ruminating more about other issues in my life and these can push out the intrusive thought. When I'm 'done' with worrying for a while, the thought will come up more often. I try to accept that this thought will never leave me for good (or will stay untill I find the right med). There was a pdoc who told me it's possible to take Seroquel PRN (as needed), but at these low dosages it will make one feel sedated as well. Maybe there is another anti-psychotic more suited for you?
  14. Nice to read you're positive about Trintellix! And have fun on Jamaica! I've been reading up on vortioxetine. There's research on it for depression, but can't find much about Pure O and/ore intrusive thoughts. Intrusive thoughts can also occur with other conditions, but what interests me that it is a SMS and not an SSRI. I still worry that the method of action of SSRI's doesn't really work for me anymore and I'm a little anxious about Anafranil (TCA) because of the cardiac arrhythmia issue I've been having lately (again, it was gone for several months). Anafranil is less selective that SSRI's, but the method of action is similar, right? It just acts at more receptor sites?
  15. 24th that's today, good luck! Will you let us know how it went? I've finally managed to find a new general doctor, but haven't talked to him yet. There's another one in my area which is considering taking me on as a patient, so I'm awaiting her response. I'll pick up my sertraline refill prescription tomorrow, I'm on 100 mg now. I wonder why withdrawing from Zoloft is so much easier than withdrawing from Lexapro.... Hopefully this new gdoc will send me to a psychiatrist the meantime I hope he or she will want to discuss my switch. I'm getting tired of staying on meds that don't work.