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About HydroCat

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  1. Started on the brand name Abilify, changed to generic long ago. No difference.
  2. I have been on Cymbalta (90 mg) for a few years, after SSRIs failed and it was great. Then I blamed it for SD and got on the med-go-round again. ... and then it turned out not be the one causing SD, so I started it again. Never failed At some point my balance may have changed and Cymbalta became too activating for me, so my pdoc replaced it with Effexor. Coming off Cymbalta (twice) caused a super-sensitivity kind of sadness for a few days after. It passes, but watch out for that. Edit: Dx is OCD, if that matters.
  3. When I switched from Cymbalta+Abilify to Effexor+Abilify I was on a slightly lower dose of Effexor than the Cymbalta equivalent and I was feeling awful. Increasing Effexor made things better. Abilify has antidepressant properties but if I understand it right it works best as augmentation and not as standalone. ...On the other hand, I am quite sensitive to the flat affect caused by APs, so I take Abilify in very low doses. My 2 cents
  4. prozac for OCD

    Used to take Prozac shortly after being diagnosed with OCD. Worked well at 80 (with Risperidone). Zero side effects. I think that the recommended max is 60 mg, but with OCD these are just, well, a recommendation.
  5. Lyrica (Pregabalin) is a GABA analogue, meaning it increases GABA neurotransmission. Mood stabilizers do this, among other effects, depends on which specific one. Lyrica should act in a similar way to that of Gabapentin.
  6. When I started taking Abilify it made getting things done easier, but I think it was the lifting of depression rather than it being activating by itself. As I remember, Wellbutrin is more activating than Abilify anyway. ... not talking about stimulants
  7. I am one of those you mentioned - Trintellix was a sugar pill to me, even at 20. People taking Trintellix shall know that it is also a 5HT1A agonist, which means that on lower doses it will hit presynaptic autoreceptors of Serotonin, leading to a decrease in its release. If that happens while its SSRI effect is not yet strong enough - you have a recipe for depression. This effect is compensated for with higher doses that hit postsynaptic 5HT1A receptors like Serotonin does. In a way, Trintellix is like a combination of SSRI with Buspar.
  8. Not sure about this specific study but keep in mind that depression is listed as a side effect for many ADs. Followed by an increased risk of suicide. If you will eventually have to stop taking Topamax, there are other mood stabilizers with various mechanisms that may be worth trying. Also, Ritalin is a great appetite supressant. Maybe too good for that.
  9. The patent on Saphris will expire in June 2020. Generic manufacturers usually start developing the generic version earlier but are only allowed to sell it in the market after that time.
  10. Not bipolar myself. Milnacipran (precursor of Fetzima) made me feel insane. Seriously, I have never seen any good feedback on these two so far.
  11. Saphris is an antagonist of 5HT2C and alpha2... which would theoretically increase serotonin/noradrenaline/dopamine availability. I would expect more of an antidepressant, maybe energizing effect. Theory aside, you will know best when you try it. With AAPs, generally, lower doses cause less of a flat affect than higher doses.
  12. I remember being more hungry when I started taking SSRIs. It was mostly temporary. Hang in there!
  13. The most calming combination I have been on was Prozac+Risperidone. You seem to have an opposite effect with SSRIs so it is not a suggestion. Apparently, GABAergic meds work better for you. In this group there are benzos, like Klonopin, and anticonvulsants (“mood stabilizers”) like Lamictal, Topamax and quite many others. The latter type is considered better for long term treatment. Gabapentin also acts on GABA but in a different mechanism. I am not a doctor, but I would look into one of these. edit: Lyrica (Pregabalin) may also be an option, although it may be very expensive, depends on location and insurance coverage. (I would mention Mirtazapine, but you said that you are sensitive to pro-weight-gain drugs)
  14. I have just recently found out that ACs are magic pills Seriously though, I'm on my first (and hopefully last) AC - Lamictal, which is pharmacologically similar to Topamax (although it has different chemistry). Titration is very slow, about 6 weeks to get from 25 to 200, which I believe should be about the same with Topamax. Dose is divided morning/evening, but while taking only one a day I found that it is better taken in the morning because it has some positive effect on cognition throughout the day. Good luck.
  15. I can only speak from my experience etc. When I had this problem on Cymbalta+Abilify, my pdoc thought it was the Cymbalta, because SNRIs are known to cause SD. That sent me on a journey theough Milnacipran->Wellbutrin->Trintellix->back to Cymbalta->Effexor. And the culprit turned out to be the Abilify being too high. Decreased abilify and SD was gone. Who knew Now I'm on 225 Effexor and better than ever