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mcjimjam posted a topic in Antipsychotics / Neuroleptics / Major Tranquilizers - The Acme Pill-O-MaticsI'm interested in Latuda, having discovered it is now available in my country, although not covered by universal healthcare for BP. I swore off AAPs years ago because I suffer from cholinergic urticaria aka heat hives. It is a life long condition but often stays dormant for long periods and can be mild. I didn't experience severe symptoms until my Seroquel was raised to 400mg and my body temp would swing from hot to cold, cold to hot etc. after that I broke out in horrible itchy prickly hives and was honestly restricted to air conditioned places all summer. Couldn't go outside or do anything that made me warm up or sweat. So I'm frightened of that happening again. I'm also frightened of permanent TD as my schizophrenic grandmother had that and a bunch of tics and tremors which scared me as a kid. I'd like to know how much you take, have you noticed any body temperature dysregulation, are low doses pretty effective or do most people take a higher dose? What was your dosing titration to begin with? Was 20mg tried for a while or did you go straight to a higher dose?