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OysterWorld posted a topic in Antidepressants - If You're Crappy and You Know ItHi crazies, So I've been in outpatient care for over a year now trying different medications and therapies to try and make me feel better. See, here's the catch... none of the medications seem to have any effect on me at all. I mean nothing. Or nothing that I can see. I read about some people seeing a marked difference sometimes when they try some new medications, either bad or good, but I've never had anything close to that ever happen to me. My case presents like an easy-to-treat depression, which is what my psychiatrist said, and that after a couple of anti-depressants I should be feeling better shortly. Yeah.. that didn't happen. We've tried so many medications that he is starting to panic now and he even recommended electroconvulsive therapy. My question is does anyone else have this problem? And if you do what are you trying/what works for you?