azul

Are there any antipsychotics that don't cause weight gain?

50 posts in this topic

No.

Am I reading your post right? Are you saying that no AAP's are weight neutral? I would have to say that I disagree and I would be willing to say that others would agree with me.

I have found - geodon, abilify, latuda, risperdal, and seroquel to be weight neutral for the most part if not 100%.

Some people may gain weight on all meds but I would venture to say that that would be rare.

Share this post


Link to post
Share on other sites

Here's what I've experienced but everyone is different, of course. Also, I took all of the meds that caused weight gain when I was either anorexic or in recovery but counting calories, so I know the weight gain was due to metabolic changes (for me), not increased eating/appetite, because I never changed the # of calories I ate.

Seroquel, Invega, Saphris, and Risperdal: Weight gain but helped

Abilify and Latuda: No weight gain but useless

Geodon and Fanapt: No weight gain but other side effects that made them unbearable

It's frustrates me like crazy that I can't find an AP that works AND doesn't cause weight gain, but, if there is one, it doesn't exist yet. I hope you have better luck.

Share this post


Link to post
Share on other sites

geodon without additional mood stabilizers has been weight-neutral for me. [it was the depakote that screwed me]

i believe abilify and latuda are supposed to be better with weight gain as well.

seroquel made me ravenously hungry and i gained weight.

as usual, YMMV.

Share this post


Link to post
Share on other sites

Abilify probably has the best rep as being weight neutral for most people. Geodon has a similar rep. WIth seroquel or risperdal its a coin toss. Zyprexa and clozapine are most likely to cause weight gain, but they also tend to work best for most people.

Share this post


Link to post
Share on other sites

I've personally found risperdal and abilify to be weight neutral, I lost 30 lbs on geodon, and the jury is still out on the seroquel. Seroquel definitely increased my appetite, but I've been managing it with roasted veggie lunches and low fat dinners.

Share this post


Link to post
Share on other sites

I think the weight gain is not as important as checking your blood sugar levels and insulin.

It is true that nobody likes to look fat. The first time I took zyprexa I gained tons of weight and my sugar levels were very high. I tapered, didn´t take it for 1 and a half years. I am taking it again. This time I am very careful with this side effect. I haven´t gained that much weight but still, my sugar levels were affected. So check your sugar levels if they are high, which is not that healthy

Share this post


Link to post
Share on other sites

I have gained 15 pounds on vryalar and can't seem to get it off.  I lost 12 pounds on abilify but it made me feel horrible unfortunately :(

Share this post


Link to post
Share on other sites

I can't for the life of me find the link to the article that discusses this, but there are some antipsychotics that are actually associated with weight loss over a period of 10 weeks, although they're typical antipsychotics... Pimozide (Orap) and molindone (Moban) are actually associated with weight loss (-3.53 kg, -1.06 kg, respectively) Some are associated with negligible weight gain over a period of 10 weeks, such as ziprasidone (Geodon) (+0.28 kg), trifluoperazine (Stelazine) (+0.34 kg), and fluphenazine (Prolixin) (+0.43 kg), but haloperidol (Haldol) is where it starts to cause ≥ 1 lb weight gain per 10 weeks, followed by aripiprazole (Abilify) and loxapine (Loxitane). Olanzapine (Zyprexa) and clozapine (Clozaril) caused the most weight gain over 10 weeks (+3.51 kg, +4.0 kg, respectively).

This article didn't discuss newer antipsychotics like Latuda, Fanapt, Invega, Vraylar, Rexulti, or anything, though.

Share this post


Link to post
Share on other sites

I can vouch for Abilify. It's been the only AP that hasn't made me gainw eight, and my pdoc confirmed that most of her patients report no weight gain on it.

1 person likes this

Share this post


Link to post
Share on other sites

Abilify seemed to give me anxiety at 5 mg.  I did lose 12 pounds on it. I am wondering if i should have stayed on it longer and the bad effect would have passed.  i am willing to try anything to lose weight.

Share this post


Link to post
Share on other sites

None that I'm aware of. You may find that some don't cause you to gain weight, but they all have the propensity to do so.

On 03/08/2017 at 0:12 AM, Alien Navel Cord said:

I can vouch for Abilify. It's been the only AP that hasn't made me gainw eight, and my pdoc confirmed that most of her patients report no weight gain on it.

I found moderate to high doses make me crave carbs and gain weight. On 5mg now, I don't have the cravings and am losing the weight.

Share this post


Link to post
Share on other sites

I lost weight on Rexulti, and it has been a great med for me. I have a long history of anorexia so weight gain is a big factor for me when deciding which med to take. Sometimes I need to gain weight but other times I'm at a healthy weight and don't need or want to gain weight. I also lost weight on a low dose of Abilify, but another time I was on a higher dose, and I gained quite a bit of weight.  I found Seroquel to be weight neutral, but then again, I wasn't on a super high dose. For me the antipsychotics that caused  the most significant weight gain have been Latuda, Zyprexa, and  Clozaril.  Of course it always varies from one person to another.

Share this post


Link to post
Share on other sites

I for one am losing weight, not dramatically, but steadily, with seroquel IR. Funny, because when I took it a decade or so ago, I gained a few pounds. Now that I have a good working cocktail, I feel so much better and have so much more energy, and that's helping immensely. 

Will also say that risperdal was neutral, didn't gain, didn't lose at the time. 

Share this post


Link to post
Share on other sites

I have been looking too, I really don't wanna keep gaining at this rate.

Share this post


Link to post
Share on other sites

Against all odds, zyprexa has been weight neutral for me so far. I gained a lot of weight on seroquel but it seems to have plateaued.

Share this post


Link to post
Share on other sites

I am on Rexulti and have not had any weight gain from it since starting it. I also take it during the day because it is not a sedating antipsychotic. So far I have had nothing but good experiences with it and no weight gain. It's a newer drug so it might be costly, but there is a coupon on Rexulti.com to get your first prescription free and pay $15 per refill after that unless your copay is higher then $200, than you have to cover the difference. I had mild akathisia which resolved in a few days and thats the only side effects I have had so far.

I say give Rexulti a try since, IME, I have no experienced any weight gain and I believe the incidence for weight gain is very low, so might be something you want to consider talking to your p. doc about. Best of luck!

Share this post


Link to post
Share on other sites
On 04/03/2012 at 4:47 PM, llama44 said:

 

 

Am I reading your post right? Are you saying that no AAP's are weight neutral? I would have to say that I disagree and I would be willing to say that others would agree with me.

 

I have found - geodon, abilify, latuda, risperdal, and seroquel to be weight neutral for the most part if not 100%.

 

Some people may gain weight on all meds but I would venture to say that that would be rare.

I think the point is that every AP has the propensity to cause weight gain. Whether it does in a specific patient is another question. Just because you take a med and don't gain at weight does not mean it is weight neutral. If it has weight gain listed as a side-effect in the PI, and they all do, it is not weight neutral. Some are worse than others and it's a matter of finding one that does not cause that side effect in the particular patient.

Share this post


Link to post
Share on other sites

I gained quite a bit on Zyprexa and lost all of it and then some when I switched to loxapine, and I find loxapine to be just as calming.

Share this post


Link to post
Share on other sites

I gained 50 pounds on clozapine but since coming off it and switching back to haldol depot all the extra weight has come back off. I am now 80kg. I am switching again to abilifi next week

Share this post


Link to post
Share on other sites

Seroquel sure didn't help my weight, but now that I'm off it I hope to be losing some. I did manage for a long time to maintain a lower weight on seroquel, but it required a strict-ish low carb diet. 

Edited by saintalto

Share this post


Link to post
Share on other sites

Rexulti hasn't made me gain much of any weight, so maybe that could be an option. On the other hand, Seroquel had me eating like a cow. Interesting how two AAP can have completely different effects on appetite and weight gain. And I've been on Rexulti for 3-4 months now.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now

  • Similar Content

    • By bestdisplayname
      Hi, my new doc told me I should give olanzapine a try because of lack of sleep. Has anyone else tried this med? I don't really dig the idea of taking something that is tagged as "sedative" and "anti-psychotic". Why would I need an "anti-psychotic" for sleeping? What kind of "sedative" effects does this pill create? I don't want to go around all numb'd down.
      The meds they give me usually don't work, anti-depressants have all been useless. Only lamotrigine has made me feel better. I really don't trust this olanzapine thing, I don't even like it's name, sounds trashy.
      Also, has anyone felt psychotherapy does help or have any kind of benefit beyond "venting out"? I could get it for free because of the mental health program in my country (just as the meds). I have tried it before and it was really a waste of time and it is frustating to hear someone just turn thoughts upside down and pretend it is some kind of insightful and constructive feedback, life if that wasn't something someone neurotic (as me and I guess some of you are since we share some kind of mental trait*) does all the time. At least that was my experience. To the ones here with good experiences with psychotherapy, how do think it helped you? My old doc once told me psychotherapy made a difference between people with mental problems getting a career and stuff like that. The difference was that the ones who did psychotherapy were 80% more likely to develop some kind of stable career. I think the thing is that 80% of every group of people will most likely be able to develop a career, regardless of psychotherapy or MI, so the stadistics just putted the "psychotherapy made this possible!" watermark to it. idk. 
      *: That made me question if people with bipolar or other mental illness share some traits beyond the diagnosis? Have you guys noticed some kind of pattern? this is not really important, just thought it was interesting
      Thanks for reading (: 
    • By ele440
      Hi 

      I am 29 years old and have been diagnosed with Bipolar Disorder and have recently taken a Zyprexa medication that has caused me to have Erectile Dysfunction. I have switched to a previous medication Seroquel which did not cause erectile dysfunction before, but I am still experiencing erectile dysfunction. I am unable to get or maintain an erection. I have been given Cialis by a urologist to help with the problem, but I am afraid of side effects that can cause vision loss to blindness as well as hearing loss or deafness. What should I do? Is it safe to take the Cialis?

       
    • By Mogli
      I just wanted to share one tiny glimmer of sunshine that I found. I am recently diagnosed with bipolar + schizotypal PD and I've started taking Abilify (aripiprozale). It is so confusing trying to learn everything all at once, and especially since schizotypal is either on the schizophrenia spectrum or classified as a PD depending on which side of the Atlantic you're on...
      Anyway I thought this might be a good place to post this article, from a couple weeks ago. It sounds like scientists are going to figure out how to make antipsychotics NOT make us gain a bunch of weight! I mean, that would be really good news, right? Hopefully this is coming true. If anyone knows anything more about this please post. I realize with how the system works it's going to be years and years but... still. It made me happy and I'm scraping the barrel here, so. :-)
      Weight Gain Receptor Linked to Antipsychotic Drug
    • By mikl_pls
      I just started lithium recently for the first time (3 days ago, today will be the 4th day) at a rather small dose of 300 mg. My pdoc didn't want to give me too much since I'm on so many meds. But she said that such a dose in some of her patients works well with regimens like mine to stabilize them as I have been ultra-rapid cycling between hyperthymia and suicidal, psychotic depression.
      I've noticed, however, in this short amount of time, that I've gained 7.5 lb since starting lithium. Is that a coincidence, or is 300 mg lithium still capable of causing weight gain?
      Also, I'd like to understand the pharmacology behind lithium. Can someone who understands it explain it to me and/or share some links to some good sources that explain it well?
      Thanks.