Jump to content
CrazyBoards.org

azul

Are there any antipsychotics that don't cause weight gain?

Recommended Posts

No.

Am I reading your post right? Are you saying that no AAP's are weight neutral? I would have to say that I disagree and I would be willing to say that others would agree with me.

I have found - geodon, abilify, latuda, risperdal, and seroquel to be weight neutral for the most part if not 100%.

Some people may gain weight on all meds but I would venture to say that that would be rare.

Share this post


Link to post
Share on other sites

Here's what I've experienced but everyone is different, of course. Also, I took all of the meds that caused weight gain when I was either anorexic or in recovery but counting calories, so I know the weight gain was due to metabolic changes (for me), not increased eating/appetite, because I never changed the # of calories I ate.

Seroquel, Invega, Saphris, and Risperdal: Weight gain but helped

Abilify and Latuda: No weight gain but useless

Geodon and Fanapt: No weight gain but other side effects that made them unbearable

It's frustrates me like crazy that I can't find an AP that works AND doesn't cause weight gain, but, if there is one, it doesn't exist yet. I hope you have better luck.

Share this post


Link to post
Share on other sites

geodon without additional mood stabilizers has been weight-neutral for me. [it was the depakote that screwed me]

i believe abilify and latuda are supposed to be better with weight gain as well.

seroquel made me ravenously hungry and i gained weight.

as usual, YMMV.

Share this post


Link to post
Share on other sites

Abilify probably has the best rep as being weight neutral for most people. Geodon has a similar rep. WIth seroquel or risperdal its a coin toss. Zyprexa and clozapine are most likely to cause weight gain, but they also tend to work best for most people.

Share this post


Link to post
Share on other sites

I've personally found risperdal and abilify to be weight neutral, I lost 30 lbs on geodon, and the jury is still out on the seroquel. Seroquel definitely increased my appetite, but I've been managing it with roasted veggie lunches and low fat dinners.

Share this post


Link to post
Share on other sites

I think the weight gain is not as important as checking your blood sugar levels and insulin.

It is true that nobody likes to look fat. The first time I took zyprexa I gained tons of weight and my sugar levels were very high. I tapered, didn´t take it for 1 and a half years. I am taking it again. This time I am very careful with this side effect. I haven´t gained that much weight but still, my sugar levels were affected. So check your sugar levels if they are high, which is not that healthy

Share this post


Link to post
Share on other sites

I have gained 15 pounds on vryalar and can't seem to get it off.  I lost 12 pounds on abilify but it made me feel horrible unfortunately :(

Share this post


Link to post
Share on other sites

I can't for the life of me find the link to the article that discusses this, but there are some antipsychotics that are actually associated with weight loss over a period of 10 weeks, although they're typical antipsychotics... Pimozide (Orap) and molindone (Moban) are actually associated with weight loss (-3.53 kg, -1.06 kg, respectively) Some are associated with negligible weight gain over a period of 10 weeks, such as ziprasidone (Geodon) (+0.28 kg), trifluoperazine (Stelazine) (+0.34 kg), and fluphenazine (Prolixin) (+0.43 kg), but haloperidol (Haldol) is where it starts to cause ≥ 1 lb weight gain per 10 weeks, followed by aripiprazole (Abilify) and loxapine (Loxitane). Olanzapine (Zyprexa) and clozapine (Clozaril) caused the most weight gain over 10 weeks (+3.51 kg, +4.0 kg, respectively).

This article didn't discuss newer antipsychotics like Latuda, Fanapt, Invega, Vraylar, Rexulti, or anything, though.

Share this post


Link to post
Share on other sites

I can vouch for Abilify. It's been the only AP that hasn't made me gainw eight, and my pdoc confirmed that most of her patients report no weight gain on it.

  • Like 1

Share this post


Link to post
Share on other sites

Abilify seemed to give me anxiety at 5 mg.  I did lose 12 pounds on it. I am wondering if i should have stayed on it longer and the bad effect would have passed.  i am willing to try anything to lose weight.

Share this post


Link to post
Share on other sites

None that I'm aware of. You may find that some don't cause you to gain weight, but they all have the propensity to do so.

On 03/08/2017 at 0:12 AM, Alien Navel Cord said:

I can vouch for Abilify. It's been the only AP that hasn't made me gainw eight, and my pdoc confirmed that most of her patients report no weight gain on it.

I found moderate to high doses make me crave carbs and gain weight. On 5mg now, I don't have the cravings and am losing the weight.

Share this post


Link to post
Share on other sites

I lost weight on Rexulti, and it has been a great med for me. I have a long history of anorexia so weight gain is a big factor for me when deciding which med to take. Sometimes I need to gain weight but other times I'm at a healthy weight and don't need or want to gain weight. I also lost weight on a low dose of Abilify, but another time I was on a higher dose, and I gained quite a bit of weight.  I found Seroquel to be weight neutral, but then again, I wasn't on a super high dose. For me the antipsychotics that caused  the most significant weight gain have been Latuda, Zyprexa, and  Clozaril.  Of course it always varies from one person to another.

Share this post


Link to post
Share on other sites

I for one am losing weight, not dramatically, but steadily, with seroquel IR. Funny, because when I took it a decade or so ago, I gained a few pounds. Now that I have a good working cocktail, I feel so much better and have so much more energy, and that's helping immensely. 

Will also say that risperdal was neutral, didn't gain, didn't lose at the time. 

Share this post


Link to post
Share on other sites

I have been looking too, I really don't wanna keep gaining at this rate.

Share this post


Link to post
Share on other sites

Against all odds, zyprexa has been weight neutral for me so far. I gained a lot of weight on seroquel but it seems to have plateaued.

Share this post


Link to post
Share on other sites

I am on Rexulti and have not had any weight gain from it since starting it. I also take it during the day because it is not a sedating antipsychotic. So far I have had nothing but good experiences with it and no weight gain. It's a newer drug so it might be costly, but there is a coupon on Rexulti.com to get your first prescription free and pay $15 per refill after that unless your copay is higher then $200, than you have to cover the difference. I had mild akathisia which resolved in a few days and thats the only side effects I have had so far.

I say give Rexulti a try since, IME, I have no experienced any weight gain and I believe the incidence for weight gain is very low, so might be something you want to consider talking to your p. doc about. Best of luck!

Share this post


Link to post
Share on other sites
On 04/03/2012 at 4:47 PM, llama44 said:

 

 

Am I reading your post right? Are you saying that no AAP's are weight neutral? I would have to say that I disagree and I would be willing to say that others would agree with me.

 

I have found - geodon, abilify, latuda, risperdal, and seroquel to be weight neutral for the most part if not 100%.

 

Some people may gain weight on all meds but I would venture to say that that would be rare.

I think the point is that every AP has the propensity to cause weight gain. Whether it does in a specific patient is another question. Just because you take a med and don't gain at weight does not mean it is weight neutral. If it has weight gain listed as a side-effect in the PI, and they all do, it is not weight neutral. Some are worse than others and it's a matter of finding one that does not cause that side effect in the particular patient.

Share this post


Link to post
Share on other sites

I gained quite a bit on Zyprexa and lost all of it and then some when I switched to loxapine, and I find loxapine to be just as calming.

Share this post


Link to post
Share on other sites

I gained 50 pounds on clozapine but since coming off it and switching back to haldol depot all the extra weight has come back off. I am now 80kg. I am switching again to abilifi next week

Share this post


Link to post
Share on other sites

Seroquel sure didn't help my weight, but now that I'm off it I hope to be losing some. I did manage for a long time to maintain a lower weight on seroquel, but it required a strict-ish low carb diet. 

Edited by saintalto

Share this post


Link to post
Share on other sites

Rexulti hasn't made me gain much of any weight, so maybe that could be an option. On the other hand, Seroquel had me eating like a cow. Interesting how two AAP can have completely different effects on appetite and weight gain. And I've been on Rexulti for 3-4 months now.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now


  • Similar Content

    • By wookie
      Hello,
      I am currently on two medications,  Zoloft 100mg and Lyrica 300mg, and had sort of a weird bought of mood swings over the last two weeks that may have been just work related though I was feeling agitated one day, and flat and depressed the next few days.  Now I am sort of about as normal as normal gets, for now.
      Different medications have been suggested to me for managing bipolar II and I am sort of hesitant to try something in addition to what I am already on because what if my medication trial goes side ways and it makes me worse?  I know start up can be rough but I just don't know if things are bad enough now to start messing around.  I was feeling anxious and scared about work (enough that I took a day off to reset myself) and wondered if I could benefit from different meds that are more in-line for treating bipolar disorder.
      I feel kind of stuck and wish I was starting from where I am on no meds to transitioning to 1st line treatment for bipolar.
      Any thoughts?  Anyone start out on meds for MDD and anxiety transition well to meds for bipolar?  Med changes are never fun in my experience.
    • By SheltieUnderdog
      I've been on and off antipsychotics sporadically for the last 7 years since age 22 (since 2011). I'm extremely sensitive to them and have a very high response to every one I've been on. I've gained 145lbs from an increase in appetite and metabolic changes, have severe akathisia that is utterly insane and makes me want to cut my own legs off, I developed severe gynecomastia from Risperdal and Invega respectively (Won the Risperdal lawsuit, but no surgeon will touch me because of my weight), experience anxiety (The most on Abilify), fatigue, drowsiness, impotence (On Fanapt), anhedonia (From aggravated depression on Haldol), blurred vision (On Fanapt), lack of concentration, mild tardive dyskenesia (In combination with TMJ syndrome, I think it's permanent), dry eyes (Can't secrete my own tears), nasal congestion (aggravated, because I have it anyway without taking APs) , disorganized speech (Literally developed a speech impediment from a combination of Fanapt and Topamax), GI issues, etc
      I've experienced almost every common recorded side effect from this category / class of drugs. The lack of control over my weight and appearance and the akathisia are the worst (that's why they're listed first and reiterated). These drugs have destroyed the relatively abysmal life I had before I developed this illness and presently cut it down to absolutely nothing. I have no life. I spend the majority of my life either going to multiple doctor's appointments for my medical issues or otherwise eating uncontrollably, and pacing back and forth and smoking cigarettes occasionally. I browse the internet with my thoughts racing. I might try to watch a TV show or play video games or play bass guitar like I used to but I can barely hold concentration or focus long enough. I want this to end, I really want out. I want to experience a fraction of life again.
      I was previously diagnosed Bipolar 1 With Psychotic Features before my 2nd and most recent episode. As I said, I haven't taken APs consistently for 7 years. I've gone off of them twice for pretty significant periods of time before I relapsed. I usually last about 10 or 11 months (almost a year) without symptoms and perform consistently better in life in general with everything gradually going back in my life to when before I was 22. The side effects and depression usually disappear within a week. At 5 to 8 months I'm very stable, but in just under 11 months I start feeling like I'm on top of the world, become severely manic and delusional, hallucinate, experience an episode, and get into legal trouble. The 1st time around, I resisted arrest during a welfare check called in by my parents and went to the hospital and the 2nd time I successfully eluded the cops by motor vehicle on the highway and got caught hours later and went to county jail.
      I understand I could be facing harsh consequences but I've never been on a heavy mood-stabilizer before. All they do is overload me with APs. After the 1st episode I stopped taking psych meds completely because of how much I despised how I felt except for Zoloft and resisted almost all treatment. I avoid SSRIs now and will this time because I think it may have been responsible for raising my mood too much before the 2nd incident took place.
      The key to preventing future incidents for me, I believe, is to make the hallucinations and mania more tolerable to where I won't feel the need to act on them. The delusions are a joke, I can easily handle them. I'm currently taking Latuda 20mg and I'm requesting that my psychiatrist allow me to keep 2 or 3 bottles stored in my cabinet or 1 on me at all times in case any symptoms were to occur while taking Lithium. During the last episode, I was frantically searching for antipsychotics or any appropriate psych medication but didn't have them because I threw all of my former meds away after the first episode had taken place. This time I will have them to back me up and if it turns out that I need to suffer immeasurably on Latuda 20mg or another AP for the remainder of my life then so be it but I deserve a chance on a mood stabilizer simply because of what I've gone through and what I'm experiencing on APs.
      Has anyone ever tried Lithium as monotherapy for schizoaffective disorder or bipolar 1 with psychotic features? I hear it still has some side effects (would like to know what all of those are) but that it's immeasurably more tolerable than antipsychotics. I realize many people use it in combination with an antipsychotic but this is not in reference to that. Is there anything better than those two that's not an AP? This post is simply to inquire about anyone's thoughts or experiences about using Lithium or Lamictal as monotherapy for schizoaffective mania. A dosage and frequency recommendation would also be appreciated from those that have taken it, although I realize that I will ultimately need my psychiatrist to determine that.
      I found 1 study on this subject from the early to mid 1980's here: https://watermark.silverchair.com/10-1-30.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAcYwggHCBgkqhkiG9w0BBwagggGzMIIBrwIBADCCAagGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMAypxqSBIPHx7kbXfAgEQgIIBeTskilYIIUxtfy4i-FH7a6BQ4SrsYxqZG44q7kWx1rVJdLbZ4PMxE33_FUje8rDj4FoUYJI27hYGzv-06pCL6xPDrbVg7n-g9QzqTwoPiRxgDv2VnqzwifudoudTuskAGEKItv5TfD1_V9opXCFF7vJXJln8ij8NeNkMLUpe_n-Xbp6TtkU7rXYdPCZ9dObhTfmQ4PEHkwKfcJcOVAjXzelMWD1EPzWPxCK5zu1l1d2w8ojnqH68mbvgaDuvBxyPTY-EEdADh9N0NIUPQCWHXZKWE2gEBsG_AbWS-bkPdgjxtXcn8Y_5KljQbU2Geb_ERYYWuWFMEk6CRs7FYte_16TOiCQVlahMabKxw0BdjlqvdGaPYZTKBoBWb9Poswigg8jbF1whmlo7WWRyCLCLdbKt4xkmZCU0qmv_j5FTFzeXsq05ptOFY10M3jpUft1xV75pMsPtVJ8U7d42OYqMksXhZyrA8B5k9XNhfJGS0XgmTTSLHNOdcTY2
    • By shweaty
      I'm on lamotrigine 300mg and was on quetiapine 100mg but it was making my thoughts worse and my mood still wasn't great, that's an understatement, my moods are vile.. didnt help that it made me put on 5kg in 2 weeks!!! I am mostly depressed nowadays.. anyway I begged him to put me on latuda as that had less side effects and treats bipolar depression. He bluntly refused and put me on sulpiride. I don't understand how blocking my dopamine will make me happy AT ALL! please help and enlighten me.. I'm at my wits end with this medication business and I feel like just quitting it all and allowing myself to be whatever it is I am weather it's dangerous or not -_____- so confused and angry about it !
    • By Blahblah
      Is this common? 9 months ago, I was the EXACT same weight as now (weight doesn't really fluctuate), however, at that time, I was 2 sizes smaller, and my Bra size (hadn't changed from High School) suddenly shrunk a cup size, clothes were baggier, arms/stomach/butt were skinnier. Basically VERY skinny, but fit/healthy (no flab).
      Now, I'm noticeably bigger, with stomach pooch (a donut is accumulating around my waist line) skinny jeans are now butt-squeeze too tight, upper inner thighs are rounder, bra size is back to the size it was.
      My diet and activity level has been the same....! How is it possible,  I could gain so much flab in 9 months, without the scale budging an ounce?? I've been maintaining my usual cardio, weight training and sculpt classes 3xper week at gym. Have I just lost muscle and gained twice as much fat or something? How can I tone/slim back down again? WTH happened to my shape?
×