Sign in to follow this  
Followers 0
Überpolarbear

Cymbalta (Duloxetine) for ADHD or other concentration issues?

9 posts in this topic

Hi,

(now that i'm free of mood swings and (maybe) psychosis or whatever) I have realized that i have probably a very massive case of AD(H)D.

The problem is that my doc is totally convinced that i have some sort of psychosis so i'm absolutely not going to get any sort of stimulant out of him although he also mentioned the possibility of ADHD. He didn't directly mentioned that I could have ADHD per se. The thing is i was diagnosed with Asperger's before and he believes the Asperger's diagnosis is Bullshit and he said you know sometimes people with ADHD produce positive Asperger's ... test results or diagnoses or whatever.

So i'm seriously "doing my homeworks" to find out what i could take for the inattention and concentration problems i have (which i have always had but when you are totally depressed or agitated as hell you dont really care but now i do care)

I'm basicly looking for some sort of ADHD relief which is not an stimulant and not Strattera (cant tolerate and insurance wont pay for it) so it will most probably be an antidepressant (which the insurance will also pay). And doc would also not prescribe wellbutrin because it's a dopamin reuptake inhibitor (psychosis)

So long story short, I went through all the possible antidepressants and Cymbalta looks quite good. It inhibits the uptake of both noradrenalin and serotonin (1:1) and to lesser extent dopamin (which is good). Note that it inhibits the uptake of noradrenalin 20 times as much as Venlafaxine (effexor) and the Nor. is the thing good for ADD. as well as dopamin.

And then there is this small study where they tested it on some kids with ADD and it worked: http://onlinelibrary.wiley.com/doi/10.1002/hup.1188/abstract

Ok whatever, Have anyone ever tried cymbalta for ADHD or any other sort of problem with concentration or attention?

Cheerz

bear

Share this post


Link to post
Share on other sites

I'm no expert, but have worked as a Pharmacy Tech on and off since I was 18 and I have never heard of it being used for ADD. Also being ADD myself have never been told about it. I may ask my dad (pharmacist) if he has heard of anything like that though.

Share this post


Link to post
Share on other sites

If your pdoc is concerned about ADHD but won't prescribe a stim, what are his plans going forward? I think his plans are probably going to be more sound than internet research done with us, none of us have anything more than unreliable anecdotal thoughts on this. I am concerned that you are minimizing what I saw to be pretty heavy psychosis from a lot of what you posted and have self diagnosed with something you now want to figure out how to treat without really listening to your pdoc.

You don't sound well, tbh.

well i'm having a shitty day. i'm indeed not well. but you are assuming i'm having heavy psychosis by reading a handful of posts (are you a doctor?)

i have been diagnosed with ADHD before and have been prescribed ritalin and strattera before. ritalin was good but doctor pushed me to take 50 mg which was too much and strattera was bad. and changing doctor lead to different diagnosis and ... whatever.

i'm wondering which is more psychotic. my old posts or diagnosing me with "heavy psychosis" by just reading them.

Share this post


Link to post
Share on other sites

I just got off the phone with my dad I needed to ask him something else, but I asked him about the Cymbalta for ADD. Cymbalta and Prozac are basically the same thing, one generic fluoxetine the other is duloxotine. The Cymbalta also being used for Fybromyalga. He has never heard of Cymbalta being used for ADD. He does keep up on current drug uses and new uses. But as a disclaimer* he is not a complete expert, just a pharmacist that I think does his job darn well.

Share this post


Link to post
Share on other sites

I may or may not be myself (maybe old self) because i have done (and am still doing) a great deal of (IMHO very successful) talk therapy and have changed my meds quite a bit (muchas less zyprexa with doc's direction). I admit that i have a rather unique personality and it might have become even "uniquer" due to "being more myself" (because of less zyprexa but much more due to the psychoanalysis i do). I don't really belive in the Schizophrenia diagnosis anymore really. It's quite possible that i have schizoid or maybe a pinch of schizotypical PD and that would explain why i sound weird (apart from english being my third or fourth language and the possible ADHD ;-) AND it's 1 am AND i've had an extremely bad day. i'm indeed confused. but the ADHD idea is all but new. it goes back to 1999.

Edited by Überpolarbear

Share this post


Link to post
Share on other sites

I just got off the phone with my dad I needed to ask him something else, but I asked him about the Cymbalta for ADD. Cymbalta and Prozac are basically the same thing, one generic fluoxetine the other is duloxotine. The Cymbalta also being used for Fybromyalga. He has never heard of Cymbalta being used for ADD. He does keep up on current drug uses and new uses. But as a disclaimer* he is not a complete expert, just a pharmacist that I think does his job darn well.

Thank you very much. i just saw the study and went yay ok cool. I found cymbalta quite compelling also because there are all these studies around that it can be given to schizophrenics. in case that i actually have it as my doc says. I cant see why it shouldn't work because it does the same thing as desipramin (particularly muchas noradrenalin RE).

Share this post


Link to post
Share on other sites

I just got off the phone with my dad I needed to ask him something else, but I asked him about the Cymbalta for ADD. Cymbalta and Prozac are basically the same thing, one generic fluoxetine the other is duloxotine. The Cymbalta also being used for Fybromyalga. He has never heard of Cymbalta being used for ADD. He does keep up on current drug uses and new uses. But as a disclaimer* he is not a complete expert, just a pharmacist that I think does his job darn well.

Cymbalta is almost the same as prozac? I was considering switching to cymbalta, but if this is true it likely won't be of much help to me then :( Isn't Cymbalta a SNRI? I know prozac has a higher affinity for NE than many other SSRIs, but I guess I assumed ADs in two different classes would be more different.

Edited by chicchick

Share this post


Link to post
Share on other sites

Cymbalta is almost the same as prozac? I was considering switching to cymbalta, but if this is true it likely won't be of much help to me then :( Isn't Cymbalta a SNRI? I know prozac has a higher affinity for NE than many other SSRIs, but I guess I assumed ADs in two different classes would be more different.

Cymbalta is NOT the same as prozac. it has very high afinity for NE. even very much higher than effexor. 20x 3x higher. and a little of afinity for dopamine. prozac doesnt have ANY afinity for NE.

Oh i'm so stupid. Cymbalta has 3 times higher affinity than effexor not 20 times. I mistaked it with Milnacipran. Sorrryyyyy

source:

http://www.ncbi.nlm.nih.gov/pubmed/18622372

Edited by Überpolarbear

Share this post


Link to post
Share on other sites

Cymbalta is almost the same as prozac? I was considering switching to cymbalta, but if this is true it likely won't be of much help to me then :( Isn't Cymbalta a SNRI? I know prozac has a higher affinity for NE than many other SSRIs, but I guess I assumed ADs in two different classes would be more different.

Cymbalta is NOT the same as prozac. it has very high afinity for NE. even very much higher than effexor. 20x higher. and a little of afinity for dopamine. prozac doesnt have ANY afinity for NE.

My mistake, I should have clarified, I meant 5-HT which often leads to indirectly effecting NE. As far as I believe (I could be wrong, not a doctor) I know Prozac has a realtively high affinity for 5-HT and is one of the less selective of the SSRIs, with Paxil being the only AD that is even less selective than Prozac. Prozac, and to a greater extent, Zoloft, also has a higher affinity (Though likely insignificant) for DA than other SSRIs, such as Luvox, Celexa, and Lexapro. Because DA is converted into NE, I would assume the indirect effects of these two factors combined, more so the 5-HT effect, would lead to a general increase in NE levels.

That's interesting about Cymbalta though. I wonder what the NE affinity of that drug is like compared to conventional stimulants like amphetamine.

EDIT: I just wanted to add sources to justify these claims.

Sources-

http://www.nature.com/npp/journal/v28/n2/full/1300057a.html

http://apt.rcpsych.org/content/7/3/170.full

Edited by chicchick

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0

  • Similar Content

    • By Lollipop4444
      Hi I have just joined here out of desperation. It's a long story but feeling as if I can't carry on at the moment. 
      I had severe post natal anxiety, insomnia and depression 10 days after giving birth 4 years ago.
      was put on mirtazapine 45mg which got me back to myself for a year. 
      I tried to go on contraceptive pills microgynon and loestrin both of which sent me spiralling back into the worst depression. 
      Stopped these and couldn't really get over the hormone problems so added venlafaxine 37.5mg to mirtazapine which worked great for a year. 
      Since December 2015 I have had to increase my venlafaxine 5 times so now I'm on the top dosage of both venlafaxine and mirtazapine.
      My relapses always happen 10 days before my period and I get so bad I can't even function and have suicidal thoughts so I have to increase my tablets. 
      I am 4 days in to my last increase and 5 days before my period and I just can't cope. My doctor has given me a prescription for a progesterone only mini pill, he has said to take this after my period so middle of next month when I'm feeling better but I am PETRIFIED that it will make me even worse and I can't increase my anti depressants. I honestly feel if this gets any worse I will have to hospitalise myself as I am so tired of fighting this awful thing and it never gets better. 
      I have cervical erosion since the birth of my daughter and had this frozen two months ago and since this my last two periods have been hell and I feel as if I'm having a breakdown. My GP says this procedure wouldn't have affected my hormone levels.
      I also take supplements Agnus castus, vitamin B6, magnesium, calcium, vitamin d, evening primrose oil, vitamin b complex food supplement and exercise when I am feeling well. 
      I just don't know what to do anymore should I take this contraceptive pill? If anyone has any experience or advice please please contact me I am desperate. 
       
      Thank you  
       
    • By rowan77
      So  l saw my pdoc today and he has decided to discontinue my lithium totally. This is due to the latest blood tests which shows I have grade 3 (out of 5) chronic kidney disease. 
      He started me on Epilim Chrono (sodium valproate) which most people know as depakote. My starting dose is 400mg. I was on this several years ago with a lot of other medications so cannot recall side effects. I know that weight gain can be a problem. My pdoc also said that I may feel sedated on it.
      Any side effects I should be aware of??
      Also, going off lithium is of great concern. I was on it for 13.5 years. I have been tapering off it and I know there is a real risk of me becoming manic. My pdoc will be seeing me more frequently to keep a good check on things and the community psychiatric nurse will be in close contact with me.
      For anyone who has had to taper off lithium...... Was it a rocky road??
      For anyone switching from lithium to valproate..... How did it go?
      Boy do I HATE change!!!!!
    • By yellowlovesgray
      I doubt anyone cares about this but I feel the need to get it off my chest because it's something that bothers the absolute crap out of me in relationships:

      I have very little patience for other people who have a diagnosis themselves that they leave untreated because "they don't need help," and therefore alllllll of my depression and panic issues are the fault of everything that happens in a relationship.

      I've been in and out of so much therapy, been on so many meds, and I'm still depressed AF and I've just learned to live with it and use whatever coping skills I have. About 5 months ago, I started dating someone who briefly mentioned he had an OCD diagnosis, and I won't get into details because I know this is a first-person site -- but he swears to all that is good and holy that he does not need "help," including medication or therapy.

      All I will say about that is that that's not completley accurate.

      He did finally medicate and it gave me hope because he was like a new person for a while, and I don't want to blame ALL of his downfalls on his diagnosis -- a lot of it is simply his personality and I know that our brains just don't work the same way. What he finds comforting and the ways in which he finds "order" and control in his life just come off as controlling, jerk-like, and quite honestly lately I think we're just making each other worse.

      It sucks because there is a LOT I like about him but I'm over the nagging, the walking on eggshells, the stumbling, the struggle with my own issues and his lack of ability to see how what he's doing is hurtful to me. 

      I'm sad, but I'm also irritated and angry and exhausted. I've tried as hard as I can to be empathetic and put myself in his shoes but I'm just not able to. I noticed he ran out of meds the other day for his blood pressure, which he admits makes him grumpy as HELL, and he hasn't refilled them. If he were to fine out that *I* did not refill a med I needed -- all hell would break loose. 

      I'm over it and I can't believe I even endured this as long as I did. Everything I do is inferior, done wrong, in the middle of dinner conversation he interrupts me to say "eat your salad, sweetie," and things that sound like they're "caring" but really just come across as a nice fat "STFU I'm tired of listening to you talk."

      We have so many bizarre rules and junk to just go about daily life that I think it's actually making my depression and my ANXIETY more difficult to cope with. Oy.

      I think I'm done with relationsihps, and just need to save up for a butler for companionship and help with the chores.
    • By katkatkat
      Hey guys 
      So I started Latuda about 8 weeks ago at 20 mg, (just the starting dose but wasnt able to get into see my doc when I was supposed to) I am definitely feeling some effects, most of them good, but I wanted to know if anyone has experienced or heard of the same? 
       
      -Weight loss. I've always been about 100 lbs, super "skinny", always get asked if I eat blah blah blah. If you're a naturally skinny girl with "a fast metabolism" you understand... Now I've NEVER been under 100 pounds (even when I never eat) but now I have been consistently eating A LOT more and my weight is dropping quickly. I was 96 pounds about two weeks after starting Latuda and I'm now at 90. Need to ask my doc but anyone experience? 
      -Insomnia. what I've noticed is that even if I get to bed really late, if it is before 5AM, I'll wake up at early 9/10. Usually, if I went to bed that late, I would sleep all day. I know, my sleep routine sucks. *I STARTED TAKING IT IN THE MORNING AND THIS HELPED 100% with sleep* I now sleep like a baby and am naturally tired by the time 10pm rolls around I actually like waking up at a decent time and starting my day, something I've never even thought was possible before this drug.
      - I am popping up all the time to get things, or move things, or do things for others in my house(like getting my boyfriends a drink from downstairs anytime he asked without whining about it first).. I think this is just me starting to feel better, but am open to different interpretations
       
      -On the whole, I am beginning to feel pretty good, but not that "I feel soooooo good," hypomania. But I do get really irritable for about 15 minutes a few times a day.
       If anyone can relate, knows if this is normal or if anyone thinks something is off, could you please give me your opinion?
       
    • By alivetoday
      Habing a hard time getting stabilized...  Was doing well on Wellbutrin, Zoloft, and Dexedrine but blood platelets bottomed out. Also was on Seroquel and Lamictal,
      Stopped Zoloft and DEX (causing platelet issues) and also stopped Lamictal over the course of a year.
      Started on Effexor 225 mg (which doesnt affect platelets) but I feel like Im becoming dysphoric, irritable, more anxious. Its making my anxiety worse. 
       
      Anyone have good cocktail ideas? I'm thinking of going back on Lamictal, maybe wellbutrin and a tricyclic...I don't know (or Buspar)...The problem is I can't take anything with Seratonin (SSRI or AMPS)...Perhaps concerta next as it has no seratonin reuptake.