8 posts in this topic
I've been on Seroquel continuously for the past 4.5 years in doses varying from 300mg to 600mg. Due to side effects and questionable efficacy for the past year or so, my pdoc and I decided that a switch in meds is warranted. She's had a lot of success with Saphris and we've decided to give it a try. To ease with withdrawal, we chose a 2-ish month transition state where my Seroquel will be waned down by about 50-75mg a week and Saphris will be increased every 2-3 weeks (2.5mg -> 5mg -> 10mg -> 20mg) depending on how I feel. It's been about two weeks now (450mg Seroquel & 5mg Saphris) and I'm noticing transient akathisia and I also feel a lot flatter. This is the first time I've ever had to switch a long-term medication like this, and I'm not sure what to expect, and whether things like flatness are common. For those of you who made switches from long term use of an AAP, how did it go for you? What sort of side effects did you notice?
Hello everyone :), it's been a long time since I've posted here and I hope everyone is doing well.
I've been taking Seroquel for a little over 4 years now, with doses ranging from 300mg - 600mg. I noticed that there's a relatively predictable sequence of events after I take my dose that disband after about an hour; my doctor has me take a single dose near bedtime. First, I notice an almost indescribable heavy/cold feeling behind my eyes and under my skin. This is always accompanied by fatigue and, sometimes, an out-of-breath feeling when I stand up. I also notice that my mood and anxiety levels go out of whack. I feel dysphoric and my anxiety goes through the roof. About an hour after my body starts processing the medicine, all of this alleviates and doesn't resurface until I take my next dose. Has anyone experienced something like this before? I've brought it up with my pdoc but she hasn't really had anything to say other than I can try switching medications.
My meds are listed below. Recently, maybe the last few months I seem to be covered with bruises. I dont know where they come from. (well some I do, I am a klutz which I blame on seroquel ) Some dont hurt at all and others are painful.
It's getting sorta ridiculous. I see my Pdoc on Wednesday and will bring it to his attention. Maybe some blood work is in order.
Has anybody experienced the same? Was it med induced or other health issue induced?
I am on lithium 1125mg/day & Abilify 7.5mg-15mg (with doc's approval that it varies between that amount) for bipolar. I am wanting to get off Abilify because it has been causing me mild resting head tremors, unpleasant and intolerable. However whenever I come down too low I predictably experience despondent mood and feel paralysed due to low mood. I've been down to 7.5mg for last five weeks and this has successfully flushed most of it out of my system and reduced side effects to tolerable levels however I decided to increase to 15mg last night due to the return of acute depressive symptoms. This made tremor return by today.
My psych is not forthcoming with any other options, I have lobbied for alternatives (there must be some!) for the past year.... nothing just "stick to your meds regime".
I need to substitute Abilify with something which won't cause shaking and I'm thinking about Seroquel (because I've been on it before) although hesitant due to weight gain. Still... rather be eating more and than have tremors if I had to chose :/.
Are these (Abilify and quetiapine) in the same class of anti-psychotics? It is feasible seroquel/quetiapine could have the similar beneficial impacts on my depression? What about off label anti-convulsants like Lyrica? I've tried Lamictal before but it made me "too happy" and I ended up in hospital so wondering if other anti-convulsants would be risky. Any suggestions?
I'm seeing the doctor in August (earliest appointment). As the shaking is coming back I will stick to the lowest dose he prescribed (7.5mg) to avoid tremors and supplement it with 25mg seroquel (which I still have a supply of from when it used to be a PRN so it is prescribed) hoping my mood will improve. I can't wait for pdoc to see me to begin to try this combo as he's away for three weeks, first appointment I could make with him is scheduled for beginning August... and another doc I want to see for a second opinion is apparently booked up for two months... my GP could be a third option for a sooner consult. To be clear this has been an ongoing issue which has been ignored by doctors as it is not noticeable to them however is clearly noticeable to me and those close to me... things have come to a head because it is getting harder to control by reducing the Abilify.
Abilify too high = tremors (intolerable side effects)
Abilify too low = depression (need something to supplement lithium)
I suffer from bipolar I. I have had a series of hospitalisations for mania, mixed moods, psychosis over past 11-5 years with no hospitalisations in the last 4.5 years, I have experienced an "episode" (pronounced drop or elevation in mood symptoms) maybe about once every six months over the past 5 years.
Thanks for any help, it helps just to talk about this stuff and know some people are listening who have experienced similar things.