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Can Seroquel Cause Depression?

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Edited by jillbelle

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Seroquel is quite sedating at lower doses and for some people continues to be sedating even at higher doses. At lower doses it's somewhat commonly used as a sleep aid. The division between when the sedation wears off depends on the individual -- so, unfortunately, can't be predicted. However, while you're still feeling tired from it you might want to take it all at night.

So you may be experiencing the sedation from the Seroquel, and that may be making you or making you feel like you're depressed.

Fiona

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I take the Seroquel entirely at night, because when I take any dosage in the AM, it knocks me out. Seroquel has been knocking me out/sedating me on every dosage since I started it in May. I've never had the sedation wear off!

<{POST_SNAPBACK}>

This does sometimes happen -- I think Erika is having/has had the same trouble.

Fiona

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So you may be experiencing the sedation from the Seroquel, and that may be making you or making you feel like you're depressed.

Exactly why I had to quit taking Seroquel. Being constantly sedated grows old after 6 months of use. It killed my anxiety but made me very down and flat. No motivation, which sucked. I needed it when I was rx'd but not for 6 months. Good for killing agitation and badass anxiety when needed but personally I wouldn't take it long-term.

Talk to doc about Provigil. It helps with the lethargy/motivation issues and is pretty safe to use if you are BP.

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I take the Seroquel entirely at night, because when I take any dosage in the AM, it knocks me out. Seroquel has been knocking me out/sedating me on every dosage since I started it in May. I've never had the sedation wear off!

<{POST_SNAPBACK}>

This does sometimes happen -- I think Erika is having/has had the same trouble.

<{POST_SNAPBACK}>

jillbelle,

Fiona is right. I am having a very rough time trying to fight the sedation of Seroquel. I have not been able to titrate up to a higher dose where some people experience the lessening of sedation.

I even asked my pdoc last week how Seroquel can help with depression if it sedates me to the point that I am a walking zombie all day long. She agreed to decrease my dose, but that really hasn't helped because low doses are very effecteive for insomnia, so my sedation is as bad as when I first started and with every increase of dosage. 

In my case, the sedation of Seroquel is making me depressed because I have no energy, no motivation, and become angry at myself for not getting anything done all day. And, anger turned inward leads to depression.

I take Dexedrine for ADD but any of its stimulanting effects are canceled out by the Seroquel. My pdoc did add Provigil to my cocktail to promote wakefulness. It has helped some, I do have several hours during the day when I actually feel like I am awake. But I am still very frustrated. You do not mention why you are taking Seroquel or if you need an AP what, if any, other APs you have tried. Do you mind sharing why you are taking the Seroquel?

Believe me! I do know exactly how you feel.

Erika 

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I think the Seroquel was meant to be an anti-manic. It does help me sleep (for at least 13 hours a night) and helps with anxiety. But it's driving me crazy. It really, really is. I have no energy, no joy, no will to do anything.

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Here is something you all may find useful I hope---

My mom cured my Seroquel sedation/fog head/CRAPPY feeling! How could a nice 47-year-old lady with Lupus cure my Seroquel woes?.../

She was always, my whole life, in love with her sports drinks. She drank them all the time and always made me go to the store to buy them. I had NO IDEA why she was addicted to them- UNTIL NOW...

(I"m trying to make this dramatic and funny!) ;)

So, I had a few glasses of Gateroaide (sp?) in the morning when I woke up with my Seroquel hang-over, and within the hour, it was GONE. Again, and again, it goes away. Now I take Seroquel at night WITH sports drinks and douse myself with the drinks again in the AM.

Hey, I feel great now. Whatever it was that wasn't right in my head with the Seroquel is fine now. Maybe try some Gateroaide! She, my mom, has had a lot of on-going, chronic physical problems and is always on new meds. She swears by the stuff! And now I know why!

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Maybe they make electrolyte drinks that are sugar free? Maybe the electrolytes are the issue??!! I was just so happy that a simple thing like a sports drink helped me be able to tolerate Seroquel and now, I'm up to 300mg.

If you and Seroquel just do not get along, don't try to force it! Remember how it does a number on the way your body works wtih sugar and insulin, causing type 2 diabetes in some people? Well, I know it makes me crave sugar like nothing else. I used to be a health-food nut and now I'm raiding the cookie aisle! I'm going to impose self-discipline after a few more bags of Oreos...

Talk to your pdoc about the sugar issue! It can't hurt. And don't let your pdoc rule you and get you to take shit that you don't get along with. Joe down the street could love Seroquel, but you might not, and that is fine! I hated it the first time around but now that I drink my sports drink I feel great. Results will vary.

Oh, and about it causing depression- the folks who distribute it in the US are prepared, with very good studies and very, very good statistical results, to submit Seroquel to the FDA at the end of '05 as a treatment for Bipolar Depression, along with it currently being approved for Bipolar Mania according to a statement at a conference they made in Paris this year. You never know, it could work in any number of ways in any one person's body, but it seems that it is dose dependent. It is stopping my moods and anxiety cold right now, so being able to get along wtih it has been key for me.

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Jill,

All mood stabiizers (including anticonvulsants and antipsychotics) have the potential to cause depression because they are CNS depressants. They slow the brain down, reduce excitatory activity through gaba or by fiddling with voltages gates, glutamate, and we know not what. By the same principle, stimulants like the dopaminergic and noradrenaline activating wellbutrin can have anti-depressant effects.

I think I read Loon say somewhere that seroquel starts to be activating at 200? If you were a zombie at 350, seroquel is probably not right for you. No one should be a zombie unless they had to be snapped out of a major manic episode and are acclimating to new meds. You developed TD instead and you were still a zombie. At low doses you are as well. Sounds really wrong to me.

Hope your new pdoc has more imagination!

7

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When I was at 50mg for sleep (a joke - didn't work), it made me feel depressed.

Best,

Chris

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I have been on this medication for about a year. I think they are causing depression. When i stop taking them, after a few day's im fine and my old self again.

I'm on a very low dose only 50mg.

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I actually started a topic

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Oops, sorry about that; didn't mean to post it. Also, I'm a member, not a guest, but the reply function on this board seems a little odd. Anyway...

I've been thinking about this topic a lot lately. I finally had to conclude: no matter what anyone says, Seroquel is a depressant for me. There is just no doubt about it. And the effect is-- or at least FEELS-- 100% independent of the sedative effect. Here's what I mean. I am super sensitive to the CYP3A4 effect, where a huge range of foods and drugs interfere the liver enzyme used to metabolize Seroquel. Most people will only notice this effect with a few things like grapefruit juice and some drugs, but because I have neurological damage from a traumatic brain injury, my doctor has told me that I'm extra, extra sensitive. Sometimes it's just impossible to avoid ALL the things that cause problems. This means that the effect is the same as suddenly taking 50% more Seroquel!

When this happens, I will IMMEDIATELY become depressed. This is very unusual for me. I've never had true endogenous depression. I have had a very few episodes, each of which was caused by specific drug reactions and each of which ended as soon as the drug was withdrawn. Once I take away the food or drug that was the problem, the depression is resolved. Because of this, I just don't see any logical explanation besides the idea that the Seroquel was causing it. And whenever this happens, I don't feel one bit more sedated than I do at any other time. The depression doesn't feel at ALL like it goes along with more sedation; while Seroquel certainly knocks me out at night, I don't ever feel more sedated during the day anyway.

I'm not a doctor, and I don't play one on TV, but I'm an MSW, my area of interest is psychopharmacology (unusual for an MSW, but very imporant, I think,) and I do a lot of research through the University of Tennessee. In my opinion, quetiapine (Seroquel) absolutely has the potential to cause depression, and I don't think it's because it's a CNS depressant. I think it's because Seroquel is such a potent serotonin receptor antagonist. So it's keeping the neurotransmitter from latching onto the receptor. Kind of works against the purpose of an antidepressant!!! Drug companies certainly don't advertise this.

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Hi,

I have been on Seroquel since May, at varying doses. It just knocks me out and makes me a zombie. On November 4, I developed TD symptoms, and was taken off the drug cold turkey. (I was on 350 mg then.) I had the worst withdrawal in the world. It seriously traumatized me. A week ago, the pdoc (I'm firing him this week) put me back on Seroquel, but at a lower dose. I just felt the latest increase (150 mg) kick in last night/today, and I feel so drugged. I want to die. This medication is so sedating for me; I swear it makes me depressed. Am I imagining this?

Also, I just started Zoloft on Thursday, and woke up today (after sleeping 13 hours) wanting to die. I don't know if it's the Zoloft or the depressant action of the Seroquel (if it does indeed have that property).

Thanks for your time.... ;)

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Hi,

I have been on Seroquel since May, at varying doses. It just knocks me out and makes me a zombie. On November 4, I developed TD symptoms, and was taken off the drug cold turkey. (I was on 350 mg then.) I had the worst withdrawal in the world. It seriously traumatized me. A week ago, the pdoc (I'm firing him this week) put me back on Seroquel, but at a lower dose. I just felt the latest increase (150 mg) kick in last night/today, and I feel so drugged. I want to die. This medication is so sedating for me; I swear it makes me depressed. Am I imagining this?

Also, I just started Zoloft on Thursday, and woke up today (after sleeping 13 hours) wanting to die. I don't know if it's the Zoloft or the depressant action of the Seroquel (if it does indeed have that property).

hi i am 19 years old i was put on seroquel. the tiredness your expirencing i also have. i am 100mg and i never feel like i have enough sleep. also i do take mine at night. i also have started experiencing rage and anger. i feel like i am raging and angry all the time. it is starting to really get in the way of my life and my relationship. anyways i just want you to know that i also have the sever tiredness and the zombie feeling and super dry mouth. it almost feels like you have drank way to much cough syrup.

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I'm manic depressive 1. Doc put me on 75mg and this drug makes me depressed as hell when I wake up. Went back to a lower dosage and still feel like life ain't worh living when I wake up. Along with my other meds, I should be able to sleep well. S has made me more manic and dangerous. When the real life problems come into play I guess there is no real solution to that.

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So you may be experiencing the sedation from the Seroquel, and that may be making you or making you feel like you're depressed.

Exactly why I had to quit taking Seroquel. Being constantly sedated grows old after 6 months of use. It killed my anxiety but made me very down and flat. No motivation, which sucked. I needed it when I was rx'd but not for 6 months. Good for killing agitation and badass anxiety when needed but personally I wouldn't take it long-term.

Talk to doc about Provigil. It helps with the lethargy/motivation issues and is pretty safe to use if you are BP.

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I have been on and off seroquel for a few years now. Its benefits are as previously stated and the draw backs are bad and seem to possibly be long term for me at least. Its been about 7 months since I last took seroquel, I used to be a highly athletic and upbeat. I no longer have that energy. I have also become a very paranoid individual I do not know if it is from all the drugs that I have been given. (Welbutrin Seroquel Adderall lithium lamictal... marijuana.)

I also did the pro vigil this would have to be the closes to fix I have ever been. It helped me be more alert and focused. I was able to expend my energy during the day and occasionally take Seroquel when I could not sleep it did effect my eating habbits though miner compared to the others. The problem is that the drug provigil is so so so expensive Im talking like a few hundred dollars for a month supply. And good luck trying to get insurance to cover it, for some reason it is close to imposable to prove that you need Provigil lol (they will hand out Adderal like candy, an amphetamine) . I am no longer takeing either because of the cost of the drugs. I wish you the best of luck and if you figure something out that works great, let me know.

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Please help me!! I was on 50 mg of seroquel and had bad anger and rage. Everytime the dr puts me on 100mg I gete very depressed!!! and don't want to live. I hate this medicine and don't think it works but I have no idea what to do...

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I have been put on a very small dosage, 25 mg, and am noticing I have been extremely depressed/panicked. I've called my pdoc and am waiting for a response. I am also on lamictal and abilify, which was working well but not addressing my anxiety -- I'm hoping I can find a better fit for me. ;)

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I have a much better resonse to Seroquel myself. I take a total of 150 - 200 mgs. 100 mgs of extended release in the early evening. It is sucha relief to take it every night. It deals with my anxiety and inner agitation so well. Then prior to bedtime I take 100 mgs regular which sedates me and makes me sleepy. I am able to get up and work by 9 in the morning. I like Seroquel a lot.

Side effects - slightly slower cognition, dry mouth, and a crazy carb craving hunger at night. That is the most dangerous part - the food cravings. It does not make me depressed. Quite the opposite I think. oh, and sometimes that awful restless leg issue

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I know this sounds weird (especially from me), but I actually think the feeling of Seroquel setting in is extremely pleasant; like a warm blanket. On the other hand, I am a huge self-opponent of having to to antipsychotics, so this makes no sense. I think in an ideal world, where I didn't have to be all high-strung and shit to make it in our cut-throat world, I wouldn't mind taking Seroquel. Watching baseball and reviewing music would be a-okay.

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I had an absolutely horrible experience with Seroquel--took it at a minimum dose on 3 occasions at night, and every time I felt like a zombie all through the next day AND part of the day after that. Additionally, I felt extremely depressed--please note the word is "extremely".

This medication is definitely not for me.

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While I did not feel depressed on Seroquel, I have since quitting a couple weeks ago. The depression "flashes" now are more frequent, and seemingly more pronounced, than before I started the drug. I was at 400mg XR and quit almost cold turkey. Horrible withdraws at first, but those are gone it seems. However, past two days have shown the ugly face of depression.

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While I did not feel depressed on Seroquel, I have since quitting a couple weeks ago. The depression "flashes" now are more frequent, and seemingly more pronounced, than before I started the drug. I was at 400mg XR and quit almost cold turkey. Horrible withdraws at first, but those are gone it seems. However, past two days have shown the ugly face of depression.

I thought seroquel was good for depression

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