Jump to content
CrazyBoards.org

alivetoday

Adderall and Effexor Reaction? Withdrawal or something else?

Recommended Posts

Hi there,

 

new to this place, wanted to know if anyone had any issue adding Adderall to their pre-existing Effexor script. I'm on 225 of Effexor XR, and since adding Adderall (it seems) but I'm not sure- that I'm withdrawing from the Effexor. I know this makes no sense...

 

Symptoms- feeling brain zaps, eye shutters, which increase as the evening and night sets in, feels EXACTLY like Effexor withdrawal to me, and I've come off it about 3 times in the past ten+ years so I know thats the familiar feeling. 

 

However- I'm sooo confused b/c my dose has NOT changed. And the only real difference is the Adderall, which I take 25-30 IR everyday. 

 

Please help- I am realllly uncomfortable with these feelings as its like everyday I withdraw or something. I will not forego the Adderall though.. Should I try another SSRI?

 

I have pretty bad depression, and anxiety (which the adderall helps strangely enough), a bit of OCD (thoughts only), and Innatentive ADD. 

 

Also, I've been on the effexor-adderall for about 1.5 months and this has continued and seems to be getting maybe worse- slightly. It started about 2 weeks in.

 

THANK YOU!

Edited by alivetoday

Share this post


Link to post
Share on other sites

Talk to your doc.  1.5 months is longer than any odd startup should last.

 

Effexor blocks the re-uptake of serotonin and norepinephrine.

 

Adderall does the same for norephinephrine and dopamine.

 

If I had to guess, I'd say the issue would be with norephinephrine... but you really need to talk to your doc.  I don't think this is normal and you need to bring it to their attention.

 

You're on an SNRI.  An SSRI only increases serotonin so that could be a good alternative if your side affects are actually due to too much norephinephrine activation - but I'm not sure it is... so talk to your doc.

  • Like 1

Share this post


Link to post
Share on other sites

Thanks, I agree I think there is some sort of interaction.  However, they seem to think increasing the effexor is the best idea- to stop the 'withdrawal' symptoms..but I'm not sure an SNRI is the best with Adderall anyways. 

Share this post


Link to post
Share on other sites

Try talking to your pharmacist. They have a lot of knowledge on how meds work/interact. If there was a major interaction they wouldn't have filled them together, but you could get piece of mind from talking to your pharmacist where you had the rx's filled. Just tell them the symptoms and concerns, they may be able to figure it out. A doctor could too, but a pharmacist can often help in situations like the one you're in.

  • Like 1

Share this post


Link to post
Share on other sites

I found out that the metabolism of ADDERALL interferes in some people with the proper functionning of Effexor- can cause withdrawals if you are a rapid CYP2D6 metabolizer.. So thats what was happening. So I go rhtough both Adderall and Effexor too quickly as well. 

Share this post


Link to post
Share on other sites

I found Effexor really enhanced amphetamine; Adderall is amphetamine. Sometimes it was too intense so for some reason I moved to another AD. I can't remember why. There really is an interaction there.

Here is what drugs.com says:

Quote

Several case reports suggest that serotonin reuptake inhibitors may potentiate the pharmacologic response to sympathomimetic agents. The exact mechanism of interaction is unclear. In one case report, a patient experienced jitteriness, racing thoughts, stomach cramps, dry eyes, palpitations, tremors, and restlessness following a single dose of phentermine ingested approximately a week after she had discontinued fluoxetine. Because of the long half-life of fluoxetine and its metabolite, an interaction with fluoxetine is possible. Similar toxic reactions have been reported when fluoxetine was used concomitantly with amphetamine or phenylpropanolamine. Additionally, some sympathomimetic agents such as amphetamines may possess serotonergic activity and should generally not be administered with serotonin reuptake inhibitors because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. The interaction was suspected in a patient treated with dexamphetamine who developed symptoms consistent with the serotonin syndrome approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine.

MANAGEMENT: In general, amphetamines and other sympathomimetic appetite suppressants should not be combined with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Close monitoring for enhanced sympathomimetic effects and possible serotonin syndrome is recommended if these agents must be used together. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

References

  1. Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
  2. Barrett J, Meehan O, Fahy T "SSRI and sympathomimetic interaction." Br J Psychiatry 168 (1996): 253
  3. Prior FH, Isbister GK, Dawson AH, Whyte IM "Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine." Med J Aust 176 (2002): 240-1

 

I would watch the dose of each and be conservative in increases.

Edited by notloki

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now


  • Similar Content

    • By Blahblah
      After 7 months of Effexor 150mg, my pdoc agreed to wean me off in order to see if my sex drive/sexual dysfunction resolves. I am very concerned with the withdrawals of this med.
      She gave me a weaning schedule, but it seems very short/quick for this drug. I am currently on 2nd day of 75mg, and feeling mainly very tired, more apathetic, lightheaded, with a bit of restless sleep. Any feedback/experiences??
      Effexor 112mg (for 3 days)
      Effexor 75mg (for 3 days)
      Effexor 37.5mg (for 3 days)
      Prozac 20mg (for 7 days)
      Prozac 10mg (for 7 days) then stop....
       
       
    • By Blahblah
      Since I've been on Effexor for 7 months, I've had zero emotional depressive symptoms (like the crying, sadness etc) negative ruminations have lessened, no anxiety whatsoever either...
      Issue is, I've become more & more lethargic. I sleep a full 10 hours per night and then I cannot get out of bed. I'm not really tired, I just literally cannot get myself to do anything. I am super content just laying in bed for hours. I read crap online for hours, I often take 2 hour naps in afternoon. It pains me to take a shower & go outside. I procrastinate on work/everything... I avoid doing things I need to do just so i can lay in bed! No interest, motivation, pleasure in anything. How can I light a "fire under my ass" again? The same issue happens with other meds that work for depression, but then they cause this!
      And no, my doc won't increase my Ritalin (which I have a tolerance to & it stopped working). She won't put me on any other stimulants which seem to be the only thing that help me in this state. Yes, I've tried Abilify add-on...not sure if I want to keep adding more meds or if there something better I can switch out in my situation?
      Seems my choice is to either be emotionally depressed or a complete apathetic sloth!!! Any ideas?
       
    • By Alexir
      Hi, I'm a new member. Former English professor, had to shift to train for another career after long-term unemployment and still looking. I'm also an author of horror and fantasy books. I joined up here because I'm looking for some help after withdrawing from the SSRI Lexapro. The only thing worse than the side effects that caused me to quit are the withdrawal symptoms. I'm three months in and seriously wondering if I have cognitive impairment. It's as if somebody took my emotions and put them on a dimmer switch. Everything is numbed out. Lexapro causes such radical changes to the brain that withdrawal seems to be especially fraught with complications, and I'm afraid I may have tapered down too quickly--over five days, after taking it about three months. The immediate result was horrific, as though my brain were on fire. That burning sensation lessened, but was replaced by a sort of emotional numbness. I know that Lexapro controls blood flow to the limbic system, which is the site of emotions, and wonder if it's possible I sustained damage from pulling the plug too quickly. Thanks. 
    • By Blahblah
      First off, I'm aware people here sometimes have issues when switching from Brand med to Generic. My pdoc started me on a Generic Venlafaxine, (maybe she didn't want there to be an issue at a later date, in case I wasn't given the specific Effexor name brand everytime, I guess)? I started on 37.5mg Mylan tab, and as I increased, not sure if it changed. Last 4 months, I was taking 150mg (in 1 tab pill), (can't remember the name).
      Anyway, I am completely confused!! I've been on different generic manufacturers and different formulations (sometimes I go to a different pharmacy, due to stock, they sometimes give me 2 75mg doses, instead of 150mg). I'm not sure even which manufacturer/brand I've been taking the longest, as I don't save the packages. However, I have noticed this last week, I've been on a different pill than months prior. I am definitely feeling different (much more tired, LAZY, spacey and sweaty) I compared my current pill (Peach, 2 dose 75mg Pfizer Venlafaxine Capsules with individual beads) to a previous one (White, Mylan Venlafaxine, it's a hard tablet inside a capsule?). I've never been on the capsule with individual beads version (usually only the hard tab).
      I don't know the difference between these formulations (capsule with beads versus hard tabs)!! I'm assuming there would be a huge difference in the release mechanism and absorption of the drug right? I'm not sure what to do, or which specific manufacturer/name to request now....I also read that only XR formulation exists (no instant) so all of these should be extended, right? Which ones have the best reputation?
       

×