Jump to content
CrazyBoards.org

Recommended Posts

Pdoc wants me to switch from Effexor to Cymbalta.  I'm worried about discontinuation effects combined with side effects from starting a new med.  Anyone have any experiences?

Share this post


Link to post
Share on other sites

No experience from Effexor to Cymbalta. But I do have experience moving from Lexapro to Cymbalta, and from Cymbalta to Pristiq.

 

I've read the horror stories, but truly never noticed anything in the way of discontinuation effects.

Edited by mjs190

Share this post


Link to post
Share on other sites

Have never been on Effexor, but took cymbalta for 4 years, and had to taper very slowly because of the withdrawal symptoms.

Share this post


Link to post
Share on other sites

MJS & Cookie, I we'll know and fear the discontinuation effects from Effexor and I imagine with Cymbalta being in the same family it would be similar. I'm hoping that switching one for the other won't be too bad because they are similar. On the other hand, why is he switching me to another med in the same family if Effexor has stopped working? This is horrible timing; I'm starting a new full time job next week.

Share this post


Link to post
Share on other sites

I agree that you probably have less to fear, since you're moving from one SNRI to another.

 

In regards to your question as to why your doc chose this route: Effexor has much less of an effect on norepinephrine than Cymbalta, which hits norepinephrine much harder than Effexor. Perhaps more norep. might be useful for your condition?

 

For what its worth, Cymbalta felt so much smoother and less side-effecty to me than Pristiq (a metabolite of Effexor)

Share this post


Link to post
Share on other sites

I agree that you probably have less to fear, since you're moving from one SNRI to another.

 

In regards to your question as to why your doc chose this route: Effexor has much less of an effect on norepinephrine than Cymbalta, which hits norepinephrine much harder than Effexor. Perhaps more norep. might be useful for your condition?

 

For what its worth, Cymbalta felt so much smoother and less side-effecty to me than Pristiq (a metabolite of Effexor)

Thanks for the info.  The more info the better.

Share this post


Link to post
Share on other sites

It makes sense that if you had success with one SNRI that your doctor would switch you to another SNRI once the first one stopped working. You know that a med from that class works. With other classes your reaction might be less well known.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Sign in to follow this  

  • Similar Content

    • By Blahblah
       I've posted on this topic before, because I'm really wondering why this is happening to me, but not on other people that have been on higher-dose stimulants (without breaks) for MUCH longer....
      I re-instated Ritalin (after a 4 month break) due to increase in work cognitive tasks. Pdoc increased the dosage because previous dose was starting to not cut it, wearing off early. I Was told I could experiment, but to take weekends/breaks off in order to "rest" . In the last 3 weeks, I've noticed drastic improvements in my mood, motivation, ability to focus on intellectual tasks/reading, and a positivity, calmness in general.
      Problem is, I am psychologically addicted. When I try to break on the weekends, I can't get out of bed, barely prepare food for myself (despite hunger), and shower, basically, these symptoms are MUCH worse than before I was taking it! I'm concerned that I'll need to keep increasing the dose, take it everyday, and eventually, it will make my condition/functioning worse in the long run (exacerbating the problem). I had old pdocs that would not prescribe me stimulants for exactly this reason.....(I am not ADD.....it is for TRD.)
      Any ideas guys? I'm very compliant, and have no inclination to abuse the dosage. This is the only thing that's made a dent in my mood and functioning and does not seem like a long-term solution!
    • By Blahblah
      How does Loneliness effect you? Any meds that help? All articles suggest that being active in regular social activities, any type of socializing, CBT, therapy, all help - but what if it doesn't for you? What if you have no friends you can depend on or trust? What if socializing with strangers, frequent group meetups, events, hobbies makes you feel worse? What if you are unable to work and have no regular in-person interaction with people?
      http://theconversation.com/loneliness-on-its-way-to-becoming-britains-most-lethal-condition-94775
       "Cacioppo’s key insight was that loneliness is fundamentally a biological problem....And so is its most profound effect – death. Analysis of 300,000 people in 148 studies found that loneliness is associated with a 50% increase in mortality from any cause. This makes it comparable to smoking 15 cigarettes a day, and more dangerous than obesity.
      ....said Cacioppo, we evolved to experience social rejection in the same way as physical pain. Brain scans have shown that “social pain”, such as being shunned by a community, activates the same region – the dorsal anterior cingulate – as bodily trauma."
    • By Stephielove77
      Hello, amigos. It’s day 3 on Ritalin SR 20 once a day,  finally prescribed after « doctor shopping » and faulty antidepressant tryouts. It kicked in right away however I did  take a nap today shortly after taking it but that’s probably my body’s usual reaction to fighting off anything new to the system. It worked right away which is a miracle!!!!!!  I have the worst job in the world which is dishwashing in my family’s restaurant, basically waiting to die. Well! Let me tell you, the soul crushing agony of a wasted 41 year old woman’s life were momentarily alleviated by focus, order, and execution. I just got on with it. S’ppose it coulda been a Placebo  (great band) effect but I’ll take it.                                Having run the gamut of, oh, every antidepressant to no avail, the last being Trintellix, which after a month left me exhausted, though I’M SURE it would’ve worked after six weeks 🤪                                          So experienced créatives,my questions to you are:  Has adding an antidepressant to your current stimulant (preferably Ritalin) made you exhausted/fried and if so for how long? Is Prozac a lost cause, especially according to Dr Charles Parker ? Ixnay on Celexa, Citalopram, Abilify, Viibryd, Trintellix, Cymbalta, Effexor...those last three were great for a 2 or so months then I slept all day, modalert didnt make a dent..Zoloft I would say I’ve had the most success with but maybe I should do the Ritalin for a couple months before reintroducing? And finally, Wellbutrin was great until the Cicadas in my head....I.E Tinnitus made me want to inpatient myself. Thank you!!               tl;dr dx’ed  MDD, no bipolar traits and other failed depression treatments include Valdoxan (Agomelatine), Doxepin, Celexa was a goddamn disaster. I aint doin’ no MAOI’s, thanks. Also I live in France and Ritalin was extremely difficult to get prescribed.                                         Thanks, Steph 
    • By HonestlyHadEnough
      Hello.

      I can't remember a time when food wasn't THE main focus in my life.  Even when I'm so full and can't eat another bite...my thoughts wander to what else I'll eat later.  Diets, eating plans, Weight Watchers Summer Camps, gastric bypass, journaling what I eat and/or exercising will START to give results the first few weeks and then my body just basically says "F you" and shuts down.  No more weight loss.  If I can't get the gratification of weekly seeing measurable change in my efforts...I'm right back to food.
      Overeating has ruined my life.  Whoever I COULD have been when I started out a sweet little girl was squandered when I somehow started using food to placate myself VERY YOUNG.  Then it became a horrible guilty, shameful and "what's wrong with me" set of glasses I looked at life through.  I was constantly pushed by my mom to stop eating, go on a diet and exercise.  She tried EVERYTHING until well into my adult life.  She too had weight/eating issues and knew what life would be like for me.  She tried to help the only way she knew how but it set up a terrible vicious cycle of sneaking food to make myself feel better and loved and treated special...that's what food feels like to me.  When I look at my family dynamics I can see all the ways life in general contributed to this addiction.  But breaking out of it has been a constant struggle.  Now for the last 2-3 years I've literally given up.  I'm 58 now and it feels like, short of a miracle, I'll die fat.  My hips, spine and knees are in terrible shape (of course they are).
      Being fat set up a way of thinking and acting in all relationships with people that I also am exhausted with.  I honestly with all my heart and fiber of my being think and feel that pleasing someone else will keep them in my life and they'll pay what little attention to me they are willing to give me.  Not all people have been horrible, I've had some great friends over my life...but of course, THEY HAD LIVES and I was never the center of anyone else's life.  I would have done anything through my mid forties to make someone else the center of my life in hopes of finally finding someone who wanted to team up and walk through life together.  Now?  I'm too old.  I'm too set in my ways.  It's just not as important.  I'm past the age of finding someone to "be a couple" with...no I'll never define who I am that way.  I'm too old for kids and of course at this point I should've had grandchildren.  There will be no one to take care of me as I get older.  I literally hope God takes me out while I can still walk and am living on my own.  I never want to be institutionalized in an assisted living/nursing home type of situation.
      Thanks for reading this.
    • By icygrave
      I was curious about Abilify, first off have you personally seen a huge increase in weight after getting on abilify? I hardly have an appetite, even without meds, and it's very hard for me to gain weight. I also exercise pretty modestly, about an hour a day. Would I be safe from weight gain caused by Abilify? The only antipsychotic I've been on long term was Seroquel, helped me a lot and I don't think I gained more than 10 pounds, which could've just been me not being so depressed and having an appetite again. Is the same likely for Abilify? I am just terrified of this because I have gained a large amount of weight, over 20 pounds from one medication which was Remeron. It really messed with my body and I am terrified of that happening again, because honestly, being fat makes me feel ugly and even more depressed.
      Second, I wanted to talk about something my   psych brought up to me. He said that Abilify and it's relative Rexulti, have "pro-cognitive" effects, meaning they help with brain fog, apathy, concentration, motivation, and even energy. Apparently both are used for ADHD, with even the makers of Rexulti trying to get it approved for ADHD. Have any of your experienced this from either of the two? Because I am in need of something that helps with cognition, mainly apathy and low, low motivation and interest.
      Bottom line, I am very interested in Abilify and its sister Rexulti. They are very interesting pharmacologically, with them being sort of unique antipsychotics... I would be taking Abilify for depression and as an add on to an antidepressant, by the way. I've always been scared of the word "antipsychotic" but knowing how Seroquel basically annihilated my depression in the past, I can't deny their benefits. Please share your experience, and as always, thanks for helping me out.
×