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StolenDance

Why do SNRI'S have a Reputation for Causing More Fatigue than SSRI'S?

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Something I've always been curious about. Shouldn't the norepinephrine reuptake feature be stimulating? It seems like drugs such as Effexor get more complaints of severe fatigue than SSRI'S

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This is the first I've heard of it. Do you have any references on this?

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I've been on Effexor multiple times and never had a problem with fatigue. The opposite effect actually. It made me more manic than SSRI'S. It don't know if it makes a difference what your diagnosis is maybe?

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I'd like to see references, too. Wellbutrin was much more activating for me than Zoloft.

 

Prozac made me manic, which is another disadvantage of SSRIs, they tend to "find" bipolar illness. I guess you could argue that meant it made me less fatigued. Until I crashed, at any rate. But I don't think a med that made me sicker is really relevant to your "argument."

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This is the first I've heard of it. Do you have any references on this?

 

There are a lot of anecdotes

 

 

http://www.depressionforums.org/forums/topic/95496-effexor-and-extreme-tiredness-and-some-trouble-sleeping/

http://www.depressionforums.org/forums/topic/53861-feel-like-a-zombie-on-effexor-xr/

http://www.socialanxietysupport.com/forum/f30/effexor-is-making-me-so-tired-190994/

http://www.crazymeds.us/CrazyTalk/index.php/topic/20563-avoid-fatigue-trouble-concentrating-etc/

 

http://www.drugwatch.com/effexor/ And that cites a study in which forty-eight percent of patients report increased fatigue. That's got to be a lot more than most SSRI'S, right?

Edited by StolenDance

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I'd like to see references, too. Wellbutrin was much more activating for me than Zoloft.

 

Prozac made me manic, which is another disadvantage of SSRIs, they tend to "find" bipolar illness. I guess you could argue that meant it made me less fatigued. Until I crashed, at any rate. But I don't think a med that made me sicker is really relevant to your "argument."

 

I'm talking about SNRI'S being stimulating, not SSRI'S. I know SSRI'S can be stimulating through personal experience, Zoloft in particular. And it may just be me, but I thought Welbutrin was an NRI that acts as an antagonist at several naCh receptors? 

Edited by StolenDance

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Most of those links are just people posting on forums about being tired and other one is drug information for patients. I could find more than those about SSRIs, especially Paxil and Lexapro. It doesn't prove that the SNRIs have a reputation for causing more fatigue. Fatigue is a possible side effect of most, if not all, antidepressants.

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The plural of anecdote is not data. I can't remember who I'm quoting.

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Most of those links are just people posting on forums about being tired and other one is drug information for patients. I could find more than those about SSRIs, especially Paxil and Lexapro. It doesn't prove that the SNRIs have a reputation for causing more fatigue. Fatigue is a possible side effect of most, if not all, antidepressants.

 

Wouldn't a bunch of people claiming something make a reputation? And the other one cites a report out of a scholarly journal where 48% reported an increase in fatigue; that is data 

 

Anyways I was just wondering if anyone had an answer pharmacologicaly speaking

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Effexor, at 300mg XR, makes me kind of sleepy. I know it does because the tiredness went away when I tried a lower dose in the summer. Unfortunately a load of crazy also showed up so I had to go back up. At 150mg XR is isn't sedating for me at all. Which is counter intuitive because the NRI action of Effexor doesn't really kick in until over 150mg. At that dose it's mostly an SSRI.

 

It seems more complicated than 

 

SRI = sedating,

 

NRI = activating.

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Effexor, at 300mg XR, makes me kind of sleepy. I know it does because the tiredness went away when I tried a lower dose in the summer. Unfortunately a load of crazy also showed up so I had to go back up. At 150mg XR is isn't sedating for me at all. Which is counter intuitive because the NRI action of Effexor doesn't really kick in until over 150mg. At that dose it's mostly an SSRI.

 

It seems more complicated than 

 

SRI = sedating,

 

NRI = activating.

Thanks for the input; definitely agree that things are way more complicated with crazy meds than they can seem on the surface. I mean, all SSRI'S have the same "main" mechanism of action, but someone can have no success with one and loads of success with another

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