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I'am taking Duloxetine 120mg for Depression and Pure O (OCD) since Feb. 2017. Unfortunately, I still have intrusive thoughts and some symptoms of depression (low mood, no energy etc.), although I can handle my everyday life somehow. However, the whole situation is not satisfying for me and my family. I'm constantly tired, lethargic, grumpy, hungry and unhappy. So what's next? I've already tried to augment with Seroquel (300mg; horrible, horrible experience) and Abilify (2,5mg-5mg, quit working after two months).
What's about switching the baseline med? Can I go back to SSRIs like Citalopram, Fluvoxamine or Paroxetine?* Or is it pointless, since the doctors kept telling me that Duloxetine and Venlafaxine were far more potent than the SSRIs...
*Lexapro did considerably well in the past, but it unfortunately pooped out after two years. Sertraline did nothing for me (I'm an ultra rapid metabolizer).
I'm on 75mg Effexor (just under 2 weeks) and I feel incredibly spaced out. I don't feel at all depressed or any anxiety, just borderline numb and "not there." My mind is an empty void & ruminations gone, but I literally feel so detached, listless. I'm continuously zoning out during the day, and in conversation. I'm struggling to spell some words (something I'm usually very good at). I could just lay around and stare at the tv like a sloth. This is sooo not me.
I've had this same effect from other antidepressants (hence why I usually end up going off them). Is this effect dose-dependent? Like, if I increase to 150mg will I feel less "tranced", more motivated or will this numbness & detachment increase even more so that I don't care about anything or anyone?? I thought the SNRI's were less likely to cause this?
I'll just preface this with info: I've tried about 30 different meds, many combos, including Cymbalta in the past (3 yrs, mixed results), It didn't greatly improve my depression, mainly made me numb, sweaty, nauseous, a bit restless/wired with sleep issues. The crazy withdrawals if I took a bit late were horrendous, so went off.
Despite this, my pdoc really wants me to start Effexor (even though withdrawal is even worse). Can someone please reassure me that it worked well for you? My symptoms are: chronic, treatment-resistant depression (with some crying/mood lability), very intrusive negative ruminations, anhedonia). Is it really worth trying despite my unremarkable/mixed experience w/ Cymbalta, and fear about withdrawal syndrome? Also what were the negatives for you (i.e any weight gain, anxiety, restlessness, paranoia, insomnia?) Thanks all.
Psych Dx: treatment resistant depression (major + persistent), generalized anxiety, adhd
Psych Rx: bupropion 450 qd, buspirone 15 bid, adderall 20 am 10pm, clonazepam .5 prn
Other Dx: celiac, gerd, vulvodynia/vulvar vestibulitis, oab, seasonal allergies, idiopathic chronic nausea, neuropathy, myalgia, & arthralgia
Other Rx: myrbetriq 50 qd, pantoprozole 20 bid, topical estrogen qd, topical clobetasol prn, topical lidocaine prn
OTC: mucinex 12-hour bid, vitamin D3 qd, fish oil qd, probiotic qd, zyrtec qd, nasacort qd, saline spray bid, melatonin prn
Previous Psych Rx: seroquel, depakote, lamictal, remeron, trazadone, lithium, ambien, sonata, zyprexa, lexapro, prozac, temazepan, xanax, rozerem
So I've clearly been on a lot of meds over the years (since first being put on seroquel in early 2013) partially because I was initially misdiagnosed with bipolar disorder. I've been on my current cocktail for quite awhile, and I had been doing pretty well with my depression but it's gotten significantly worse lately due to some life events + unyielding chronic pain that has been getting worse for the last two years.
For the neuropathy I tried gabapentin for several months and it did absolutely nothing. I've been suggested Lyrica (which even with my good insurance is still $100 a month or $200 for 3 months with a mail order pharmacy which is a lot more than I can reasonably afford) and Cymbalta.
Does anyone with depression and/or neuropathy have any experience with taking Cymbalta and Wellbutrin together? The two SSRIs I've taken (lexapro & prozac) in the past both gave me severe gastrointestinal side effects and I wasn't able to stay on them long enough to see if they even helped. It would be great to have a cheap, generic drug improve my nerve pain and depression, but I'm nervous about trying another SSRI.
I'm also fairly uncomfortable with the idea of going off bupropion, bc it's been pretty damn effective if not adequately so. Because when I wasn't on bupropion I was a MESS and I'm afraid of going back to that level of depressed.
Also curious if anyone has any success with using any med, Cymbalta or otherwise, as an adjunct treatment for depression?
I have recently gotten back to therapy so I'm hoping that will help some but it's hard to follow through on anything from my therapist (or from my physical therapists, doing anything besides going to work & sleeping) bc of executive dysfunction, constant fatigue, pretty severe anhedonia, general feeling of emptiness.
So, I am not 100% better.. I still have some weird side effects, but I am no longer taking Cymbalta! I have been wanting to come off this drug for awhile now , I tried once, failed. Then another time, Nope. And 3rd time , well I guess this was the charm. Let me tell you... the withdrawal , terrible. My pdoc increased the Seroquel to level it out..and it was ok for a few days then all of sudden bam... it began. I sweated, it wasn't even like sweating it was a damp cold clammy sweat when after you get sick or have the shits. My moods were terrible. The crying spells, I had to be watched. I was very Manic Depressive. I was sick to my stomach, vomiting etc. I couldn't sleep, I stayed up until 4am and had sleep paralysis. I honestly wanted to give in and go back on it, just so I could not have these side effects. I pushed thru it. It took me about 2 weeks of hell and now it's tolerable, I am starting to feel better where I can actually drive again with out getting sick.
I am getting a little worried tho..because now that I am no longer on any SSRI, or SRNI.. I am starting to feel a lil wound up and agitated. Very hyper too. Hoping this will pass.
Anyway just wanted to express that I made it (so far), even tho I wanted to go to in-patient and my t doc wanted me to go to, I didn't. I fought thru this.
If any of you came off this drug , how long did it take you to sort of feel balanced again and get off that rocky boat.