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I’ve been on Effexor the last 3-4 months, I haven’t felt anxious at all, or depressed. Seems great right? I increased a week ago (to 150mg), and since, It’s increasingly difficult to get out of bed in the morning. I sleep really well, I don’t feel tired. I just feel soooo comfortable, relaxed, calm, cozy and content that I just lay in bed for an extra 3 hours. My mind empty.

The last few days, I’ve been completely shirking off/avoiding all responsibilities: called in sick to work twice, skipped my courses, just to lay around in my pjs and do nothing! WTF? I No desire to socialize, haven't showered the last 2 days...It reminds me when I was on Celexa - I became so lazy/apathetic/disinterested that I had to discontinue.

Is there such a thing as “too much serotonin?” Maybe I should just wait things out, until I get used to it? I feel like I need to increase my stimulant & drink extra coffee just to light a fire under my @ss.

Edited by Blahblah

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I experienced something similar with Zoloft after being on it for a while. It worked at first but then it got to where I had no energy or interest in doing things and just laid around all day feeling blank. Not depressed or sad, just blank. It got better when I started tapering down. I'm curious if anyone knows why this happens.

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Yeah, I'm aware this is very common with SSRIs..many of them are known to cause various degrees of "emotional blunting," emotional numbness, apathy, low motivation, lethargy, brain fog. This is all great if your symptoms you are treating are: extreme crying spells, sadness, panic or whatever. But the other side, if you aren't at that level of depression/anxiety, I think they can numb you out too much. I wonder if this is the action of Serotonin in particular that causes this?

At any rate, I will stay on Effexor for now, and maybe try to go higher in dosage. I thought SNRIs had more action on Norepinephrine or Dopamine eventually...

I see you are on Prozac - does it not have the same effect?

Edited by Blahblah

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4 hours ago, Blahblah said:

I see you are on Prozac - does it not have the same effect?

Nope. And the Zoloft didn't either until I'd been on it for two years. I think I read a study about this a while ago ... I'll see if I can find it.

edited to add - the reason I think it was an effect of the Zoloft rather than my depression worsening is that my energy and motivation returned as soon as I tapered off the Zoloft.

Edited by Juniper29

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Well darn it, I can't find the paper I thought I had read. There are some studies mentioning apathy/indifference induced by SSRIs (nothing with SNRIs that I could find) but nobody seems very interested in how that happens. And it's more extreme than emotional blunting - at least, it was for me.

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Happens with me too, but my mind was so loaded with BS that it helps me to pay attention to other things...

I'd say if you were happy at 75mg stay there Blah, I wish I could have again what you're getting...My effexor doesn't seem to be working as well.

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@BrianOCD Man...Didn't it work for you for YEARS? Has it completely pooped out? Do you feel like it's doing anything - like which symptoms are you having most issues with (depression/anxiety or OCD?)

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3 minutes ago, Blahblah said:

@BrianOCD Man...Didn't it work for you for YEARS? Has it completely pooped out? Do you feel like it's doing anything - like which symptoms are you having most issues with (depression/anxiety or OCD?)

It's still working on some level, it's just not working as strong as it used to, I have to raise the dosage.  I know it's working cause I haven't had panic attacks while on it...

I was on 300mg for like 7 years so it makes sense I would need more raises, talked to PDoc and he said he'll go up to 450mg if he has to.

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