So I know I’m not to take nsaids with lithium as it can increase lithium levels and wreak havoc, including toxicity, seizures, etc. Problem is, I’m in bad pain and can’t take anything. Went to dr. I tore the meniscus in my knee and messed up my hip and back (already had herniated discs but they’d been doing well). Being active brought me out of a year-long depression and I don’t want to give up and be the blob in bed I used to be. But this pain is bad and Tylenol (acetaminophen) does nothing. The pdoc won’t lower my lithium dose so I can take some ibuprofen or something. Nobody has an answer to “Tylenol does nothing “. I’m wondering if taking half the lithium it would be ok to take some nsaids. Just wondering if anyone else has gone through this.
I'm a 43 yo guy who's been severely depressed since I was 19 and I'm amazed I'm still alive. Antidepressants (and there's very few I haven't tried, including the popular combos) either do nothing, make me more depressed or help partially for a few weeks and then poop-out. I've never had mania/hypomania (other than a period on Abilify).
After my stay at an inpatient psych ward in February, a young PDoc added Lithium to my Nardil (which, incidentally has been my most successful med to date but now does nothing) on the hunch that I might be BP2-ish. Whilst I can't say I went "WOO I'M FIXED", the Lithium certainly had a positive effect for a couple of months. Which has since just waned and stopped. So now I'm desperately depressed again.
I'm seeing my PDoc soon to discuss alternative BP2 treatments. Top of my list of suggestions (since he is malleable in his dispensing) is Lamictal. But should it be? I read a lot of positive feedback on it's effect on depression but the data says it's poor. Should I perhaps be aiming towards an alternative? There are so many it's quite bewildering and I'm relatively new to the BP2 scenario.
Any tips are most appreciated.
Does anyone have any experience specifically with the Depakote+Lamictal combo (with or without other medications). I've been on Depakote now since about November of last year but we're swapping out the Trintellix for Lamictal because my new insurance in July might give me a hard time about covering Trintellix. And we (my pdoc and I) figured that demonstrating an approved medication doesn't work (if it doesn't work that is) should be something we should try before submitting the step therapy paperwork for Trintellix. For this new insurance, they not only require that you try at least two other generics, but the "Restricted Access" meds also are only allowed to be used for FDA approved indications (i.e. Trintellix is approved for MDD but I'm BP2).
I started Lamictal on Thursday. 25mg every other day for 2 weeks. Then 25mg every day for two weeks. Then we'll decide if we want to increase it again to 50mg for another two weeks or if we want to increase the Depakote or Rexulti.
I don't recall Lamictal having such a difficult startup when it comes to GI discomfort. I remember the antsy almost anxious feeling, and I remember the headaches, but I'm also having nausea, some mild stomach cramping, diarrhea, but fortunately no vomitting. Has anyone else ever taken Depakote and started Lamictal and found they had a hard time. Better yet has anyone ever taken Lamictal both with AND without Depakote and found it less tolerable when taken with Depakote?
I am aware of the medication interaction between these two meds. So I know that Depakote is going to increase Lamictal blood levels and might amplify some of these side effects. It's just more difficult than I remembered from the last time I took it years ago when I wasn't on Depakote and I wasn't really expecting it to be this much worse. Granted, I've only taken two doses at this point. So I might be jumping the gun and might find that I feel better later this week. But I'm also supposed to be discontinuing the Trintellix on Thursday. And if I'm still having a hard time adjusting to the Lamictal, stopping Trintellix at the same time could make me miserable, and I know that.
Anyone have two cents?
I’ve been pretty stable on Depakote, but it sure does come with some undesirable side effects. Somehow it makes me feel overwhelmed. It’s kind of a brain fog 2.0 feeling. Also it haven’t helped much with my anxiety, and there’s still some depression left too.
I’m also on 2 antidepressants and a small dose of gabapentin, with no luck.
What are your experiences with lithium or seroquel? I do not want to feel like a zombie and also do not want to feel too flat or foggy