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morpheus

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About morpheus

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    male
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    Psychiatry,Neuropsychiatry, Pharmacy

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  1. Glad to hear you're doing great. Valproate doses are often changed in either directions according to symptoms, often blood levels are not so improtant than clinical symptoms. For Bipolar 2 serum levels of VPA doesn't need to be very high.
  2. I'm also struggling with opiate addiction, I can battle physical withdrawal, but psycological is the hardest part for me, particulary cravings, I don't know what to do. I was refused to receive buprenorphine or methadone programm. Naltrexone made me extremely angry and violent.
  3. I also had this side effect about music, it will not fade,but you'll get accustomed to it Yes,that's a right ratio
  4. I think epoxide hydrolase aren't blocked 100 % by VPA, some CBZ- 10,11-diol are formed. But maybe, yes, CBZ itself have some inducing properties to UGT. Go figure.
  5. It's hard to say. Actually neither CBZ nor CBZ-E are enzyme inducers,but CBZ 10;11-diol which is formed from CBZ-E, but while valproate inhibit epoxide hydrolase, then there should not be enzyme induction theoretically. 1200 OXC = 800mg CBZ
  6. With initial carbamazepine therapy, hepatic enzyme induction begins within 3 to 5 days and is complete within 21 to 28 days. (https://www.mdedge.com/psychiatry/article/66146/beware-cytochrome-p450-inducers-prescribing-tips-prevent-drug-drug) So I doubt that CBZ increased clearance of brexpiprazole significantly so far
  7. Any side effects from CBZ? Actually most side effects are not from CBZ, but from CBZ-epoxide metabolite
  8. How about pushing CBZ dose faster? When I switched from Depakote to CBZ, I withdrawn Depakote and began take CBZ 200mg bid
  9. Seroquel can take up to 4 weeks to really work. 50mg is small dose,basically a antihistamine helping with sleep only
  10. mostly irritability, some anxiety I see you're taking clozapine in the am, that doesn't sedate you?
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