Jump to content
CrazyBoards.org

Schlep

Member
  • Content Count

    82
  • Joined

  • Last visited

About Schlep

  • Rank
    The Bad Luckster.

Profile Information

  • Gender
    male

Recent Profile Visitors

The recent visitors block is disabled and is not being shown to other users.

  1. His words were "low dosing range". I'm assuming it was because pills come in 2.5 mg.
  2. How long have you been on prazosin? I suffered derealization on a beta blocker. Maybe alpha blockers work similarly.
  3. Just one dose of whatever the lowest dosage was, since I'm very sensitive to meds (that's why the pdoc originally suggested Zyprexa due to it's low dosage range.) I was still getting sick from Ativan at that time, and had taken my last crumbbs of Ativan on that day. The anxiety was definitely from the gabapentin though, since I felt it kick in after taking it. Hey browri, what different kinds of factors predispose one to be sensitive to psychiatric medications? Are there a lot of biological ones?
  4. It could be dangerous between the dosage equivalency and the number of extra expired pills you'll need to take to match the potency of a fresh batch.
  5. What was your personal experience in evaluating olanzapine and brexpiprazole; e.g differences in their main effect, side effects, etc. Which one did you think was better? I've also seen amisulpride and sulpride suggested, but their not available in the US. What APs are they most similar to? On a more esoteric note, do you know anything about the effects of mold (toxic or otherwise) on neurotransmitters? I've had incidients with mold directly affecting my condition in the past, and it could be a factor this time. I tried gabapentin and it immediately made me anxious. Would that indicate anything as far as glutamate is concerned?
  6. Okay, something here really stands out, and it's glutamate. Some cursory research shows that it can be responsible for anxiety, restlessness, and an inability to focus, which sort of covers what I'm going through. Perhaps it was high glutamate that kept the benzos from working the way that they should. Can glutamate be tested (I have a bunch of test results from the last few months and it could be on there), and are there drugs that lower it? I'd also like to add that my anxiety condition was triggered by caffeine almost three decades ago, which is partly why I suspected dopamine. I vaguely knew already that GABA and dopamine exclude eachother, but didn't know the mechanism. So maybe I react to dopamine normally, but not the glutamate. Does the brain naturally rid itself of excess glutamate? The doctor in my last stay at the psyche ward wanted to increase the dosage of Zyprexa to 7.5mg, but I assumed more Zyprexa woukd be more sedating, and that's when I decided to try Abilify. Is Olanazipine one of those weird drugs that acts differently at different doses. As far as visteral, I was given 50mg after I had stopped the clonazepam and had a negative reaction to it that included brief problems with memory. I really never want to take it again. I was considering remeron, but there are some major contraindications with nortriptyline. As far as I know, I had no thyroid testing done since that first psychiatrist, who retired almost twenty years ago. One of my previous medical doctors used to check my nortriptyline levels fanatically, but I think over the past ten years it was only tested once as an outpatient, and that was by request. The levels were tested as an inpatient (I think again at my suggestion), with a result of 220; thus my dosage was lowered to 125mg. I was taking Abilify about a month in total, and once the negative effects started I was suffering them right until the end. I was thinking of Rexulte, but am concerned it might be too much like Abilify and I'll just react badly to it eventually. No psychiatrists in my area seem to offer genetic testing, so I would have to do it independently.
  7. I think Zyprexa is the only thing I've felt have a direct alleviating effect on anxiety that was similar to the way clonazepam used to work on me.
  8. Well, one thing is not noticing when I make such awful typing mistakes. Ugh. The original topic actually came from another thread which I reposted here verbatim because it swung so sharply towards ADs. I actually have a copy of that book which a former Pdoc gave me several years ago. My problems started about three months ago with unexplained mild anxiety after being very stable for seven years (I did not have access to a pdoc at this time). At the time I was on 150mg of nortriptyline and about .25mg of clonazepam. Of course the first thing I did was raise the clonazepam, and things only got worse, reaching the point where I felt physically ill with bouts of nausea, not to mention severe depression and anhedonia, which were very atypical symptoms for me. It took me a month it was the clonazepam that was making me ill. I admitted myself to a psyche ward a few days after stopping the clonazepam and without extra medication much of the anxiety and physical symptoms lifted, though not the depression. I finally tried some Ativan (.5mg), which I was initially reluctant to because it was another benzo, and at first felt an anxiety that gradually turned into a kind of euphoria that helped lift the depression (dopamine?). I knew this wasn't a real solution, but apparently it was enough for them to discharge me. So I ended on on .25mg of Ativan 3X a day (the euphoria from .5mg was a bit strong), and would always get a bit nauseous the first dose, but it wouldn't persist. I should add that the euphoria was all I felt from the Ativan, and not any of the anti anxiolytic effects I was familiar with from clonazepam. But after a few weeks I started reacting to it the same way I was from the clonazepam, so I ended up in the psyche ward again. I first tried gabapentin, which made me anxious, then Zyprexa (2.5mg -0 5mg) for about a week, which made me slightly sedated and kind of emotionally flat. I tried Abilify (5mg) next, and responded well to it, possibly more due to its lack of side effects than anything it did in itself (no euphoria). Either way I got a bit stable and was discharged. Maybe a week after getting home I started having the same bad reactions to the Abilify (though the anhedonia was initially not as bad, but some new symptoms were a kind of stiff feeling in my hands and feet, as well as leg cramps). It persisted for about four days, during which time I reduced my dosage to about a crumb that I took in the evening so I could stave off any withdrawal until I could see a Pdoc. I felt just as crappy on that little piece as I did a full pill (which was also the case with Ativan), but it was tolerable for a few hours and dissipated by the morning. I was actually feeling pretty stable until last friday night, and then the whole business started again. It began not long after my nightly dose of nortriptyline (reduced to 125mg because high levels were detected a few months ago), with the onset of a warm feeling that I felt strongly in my stomach and spread to the rest of my body, dry mouth (which I've often experienced with nortriptyline, but never at night right after having taken it), ear ringing (also unusual) and then insomnia, anxiety, and anhedonic depression the next day. I immediately stopped the Abilify, and carefully noted how things transpired the next few nights. It all followed the same pattern, and I was forced to conclude it was nortriptyline. By night four I tried reducing it to 100mg, and then came brain-on-fire anxiety (though I can't rule out Abilify withdrawel as the cause.) I was able to get my Pdoc to call in some Zyprexa (2.5mg) by Tuesday, which I felt was my best chance at temporary relief, and it immediately started helping the anxiety (the reduction of the nortriptyline to 75mg could be helping too.) I'm on day two now, and things on the anxiety side at least are slightly better. I'm largely thinking a dopamine imbalance due to the benzos, especially in regards to the euphoria being the only thing I experienced from Ativan. Maybe excess dopamine is destroying GABA production, and the benzos brought dopamine up to some critical point that resulted in illness. Maybe this is somewhat supported by my so far positive reaction to Zyprexa's dopamine antagonism? It's the only neurotransmitter imbalance theory I can come up with, though it might not explain the depression and anhedonia. I'm curious about which plays a larger role in anhedonia: dopamine or serotonin. But what I'd really like to go after are possible physiological conditions that might be causing this. My first Pdoc seemed to regularly test my thyroid, as she had me on synthroid my first year. I believe it affects dopamine production and a lot of gut developments that affect neurotransmitters. Metabolism could be some kind of issue too, perhaps reflected by the recent immediate onset of side effects from the nortriptyline. During this whole period I've noticed a kind of "vapor" that produced a taste and smell from medications affecting me adversely that I've never experienced in the past. But at this point, as far as I know, no one treating me has considered anything other than brain chemical imbalances.
  9. One source was here; "agonsut" was probably the wrong term. https://books.google.com/books?id=KKlVf-L5DSkC&pg=PA137&lpg=PA137&dq="dopamine+transporters+nortriptyline"&source=bl&ots=XxhftESEv4&sig=h_f_jwp9QqzFPtGy3b-UqIbthkg&hl=en&sa=X&ved=2ahUKEwjA8oTy5eHfAhWhd98KHfpuB7QQ6AEwAHoECAUQAQ#v=onepage&q="dopamine transporters nortriptyline"&f=false Another user elsewhere remarked that nortriptyline's 5HT2C antagonism also increased dopamine.
  10. Sounds promising. Is it at all plausible to consider switching to a med without tapering the nortriptyline (and what meds would be best, if so.)? I remember an old pdoc saying something about being able to go straight from nortriptyline to Zoloft. I know she was contrasting this with the washout method of switching from nortriptyline to Prozac (which I had attempted), but the impression I got was that it was a one day switch. Have people done that with Zoloft or other meds? Update: I was able to take some Zyprexa last night (2.5 mg), and it seemed to calm the anxiety a bit (and nortriptyline was also lowered by 25g over the past two nights.) I've read that Zyprexa is also 5HT2A antogonist, so does this throw my theory into question?
  11. I've seen a lot of reports to the contrary. It seems to be the reason they're addictive... https://archives.drugabuse.gov/news-events/nida-notes/2012/04/well-known-mechanism-underlies-benzodiazepines-addictive-properties
  12. Yeah, I figured the bupropion wouldn't be good. Is there any reason why SNRI's are preferred?
  13. Okay, now after 26 years nortriptyline is starting to affect me adversely and it looks as though I might need to switch antidepressents. I think my problem is a sensitivity to dopamine (I've read that nortriptyline is a dopamine agonist on a certain part of the brain, and I'm having the same problems as I had with benzos and Abilify.) So the first criteria would be that the new med doesn't alter dopamine. Second criteria would be something I could make an easy switch to. I tried amitriptyline a few years ago and couldn't handle it, so that's out. Are there any drugs very close to nortriptyline that don't affect dopamine? What would be the next logical choice? As far as the second criteria, I've been looking at http://wiki.psychiatrienet.nl/index.php/SwitchAntidepressants, and see these as possibilities: fluoxetine, bupropion, citalopram, clomipramine, dosulepine, doxepine, imipramine, maprotiline, sertraline. venlafaxine. I'm not sure how many meet the first criteria yet.
  14. Okay, now after 26 years nortriptyline is starting to affect me adversely and it looks as though I might need to switch antidepressents. I think my problem is a sensitivity to dopamine (I've read that nortriptyline is a dopamine agonist on a certain part of the brain, and I'm having the same problems as I had with benzos and Abilify.) So the first criteria would be that the new med doesn't alter dopamine. Second criteria would be something I could make an easy switch to. I tried amitriptyline a few years ago and couldn't handle it, so that's out. Are there any drugs very close to nortriptyline that don't affect dopamine? What would be the next logical choice? As far as the second criteria, I've been looking at http://wiki.psychiatrienet.nl/index.php/SwitchAntidepressants, and see these as possibilities: fluoxetine, bupropion, citalopram, clomipramine, dosulepine, doxepine, imipramine, maprotiline, sertraline. venlafaxine. I'm not sure how many meet the first criteria yet. (I'm also going to post this in it's own thread on the AD forum.)
  15. Yes, all those causes are a bit dramatic. Couldn't the thyroid just develop a simple disorder like every other organ in the body?
×