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Found 12 results

  1. Hello everyone, I hope everyone's December has been off to a good start. I am back, on the med merry-go-round and also sober from opiates.... Again (16 days as of now). So I was taking wellbutrin as an add on to my Prozac, and it really didn't help and might have made me worse, losing dramatic amounts of weight, a lot of intrusive thoughts, very depressed (though that's probably just it not doing much for it. And getting off drugs.) so I'm now on the Rexulti starter pack. I'm here seeking others experiences with abilify and rexulti, since they are both dopamine partial agonists and 5-ht1a partial agonists, amongst other things. I'm very nervous about taking an antipsychotic for depression, though... And just want to know of other's experiences starting these medications. How were the side effects? If you had any, did they eventually go away? Did you gain weight? I appreciate anyone who shares their experience. I've asked about these meds before, but I'm so nervous about it I just want reassurance. A lot is changing around me. Thank you all so much, and I hope the holidays have been treating you well.
  2. Aripriprazole: Intrinsic activity = 60% on post-synaptic D2 ; up to 75% on pre- synaptic D2 receptors.[1] Brexiprazole: Intrinsic activity = Up to 46% [2] Cariprazine: Intrinsic activity = Up to 71% [3] Aripriprazole is a partial agonist with functionally antagonist activity on receiving neurons and functionally agonist activity on firing neurons; both of which dampen down dopaminergic neurotransmission. Aripriprazole can increase dopaminergic activity in the mesocortical pathway, unlike dopamine blockers, Aripriprazole partially agonizes D2, D3, 5HT1A and to a lesser extent D4 receptors; antagonist at 5HT2A, as other atytpical antipsychotics.[1] Brexpiprazole has more blocking and less stimulating activity at the dopamine receptors than its predecessor, aripiprazole, which may decrease its risk for agitation and restlessness. Specifically, where Aripiprazole has an intrinsic activity or agonist effect at the D 2 receptor of 60%+, Brexpiprazole has an intrinsic activity at the same receptor of about 45%. [2] Cariprazine is a dopamine D2- and D3-receptor partial agonist, with higher affinity for D3 receptors, as opposed to the D2antagonism of most older antipsychotic agents.Cariprazine has lower intrinsic activity at D 2 receptors than aripiprazole. Its intrinsic activity is up to 71% [3 ]
  3. Abilify (Aripriprazole) is a partial agonist on dopamine receptors with 60% the activity of dopamine on receiving neurons and 75% activity of dopamine on firing neurons [1]. Abilify is the only antipsychotic which can increase dopaminergic activity in the mesocortical pathway through dopamine partial agonism. Abilify is a 5HT1A partial agonist (68%), which causes dopamine levels to go up in the prefrontal cortex. Abilify is also a 5HT2A antagonist; which has antipsychotic and antimanic properties [2]. Here are the Four Dopaminergic Pathways and Abilify's Effect on them 1. Mesolimbic (Abilify decreases activity) 2. Mesocortical (Abilify increases activity) 3. Nigrostriatal (Abilify dampens down) 4. Tuberoinfundibular (Abilify does not cause prolactin release unlike dopamine antagonist antipsychotics. In fact, even low doses of Abilify can reduce prolactin release caused by dopamine blockers). Abilify reduces neurotransmission in three of the four dopaminergic neuronal pathways.
  4. I was curious about Abilify, first off have you personally seen a huge increase in weight after getting on abilify? I hardly have an appetite, even without meds, and it's very hard for me to gain weight. I also exercise pretty modestly, about an hour a day. Would I be safe from weight gain caused by Abilify? The only antipsychotic I've been on long term was Seroquel, helped me a lot and I don't think I gained more than 10 pounds, which could've just been me not being so depressed and having an appetite again. Is the same likely for Abilify? I am just terrified of this because I have gained a large amount of weight, over 20 pounds from one medication which was Remeron. It really messed with my body and I am terrified of that happening again, because honestly, being fat makes me feel ugly and even more depressed. Second, I wanted to talk about something my psych brought up to me. He said that Abilify and it's relative Rexulti, have "pro-cognitive" effects, meaning they help with brain fog, apathy, concentration, motivation, and even energy. Apparently both are used for ADHD, with even the makers of Rexulti trying to get it approved for ADHD. Have any of your experienced this from either of the two? Because I am in need of something that helps with cognition, mainly apathy and low, low motivation and interest. Bottom line, I am very interested in Abilify and its sister Rexulti. They are very interesting pharmacologically, with them being sort of unique antipsychotics... I would be taking Abilify for depression and as an add on to an antidepressant, by the way. I've always been scared of the word "antipsychotic" but knowing how Seroquel basically annihilated my depression in the past, I can't deny their benefits. Please share your experience, and as always, thanks for helping me out.
  5. I've taken Abilify for almost 10 years. I was originally put on it for anxiety, which was rather unwise. I havn't felt good from doing exercise since being on it. However, It did seem to help with OCD. My OCD used to center around cleanliness, now I don't care much. Now my OCD involves intrusive, repetitive thoughts. I am on 10mg Abilify 300mg Luvox, 50 mg Lamictal, 500mg Depakote, and 50mg hydroxyzine as needed. 5 months ago my Abilify does was increased from 5mg to 10mg. Everything was great for a month or 2, not anymore. I've been told that the intrusive, repetitive thoughts are part of OCD and not schizophrenia. However, I'm wondering if I have schizophrenia anyway since the thoughts are related to my daily activities. Has anyone heard of intrusive thoughts being linked to schizophrenia? If so, would a different antipsychotic be more effective? To complicate things, I am a slow metabolizer. Geodon knocked me out for 18 hours! A prior doctor put me on perphenazine after that because he found an article showing the same problem in someone else, and success with perphenazine. I found an article that stated that perphenazine is metabolized by three enzymes while Geodon is metabolized by one. Unfortunately I don't have those articles now. The downside to perphenazine is that it made me depressed at high doses. I tried risperdal, but It made me anxious. I'm willing to try anything again as long as I'm not asleep for 18 hours. Any ideas?
  6. Hi there, I was just wondering if anyone here has tried Rexulti as an AD adjunct for depression. Please tell me what you thought of it, I know it's very similar to Abilify, but surprisingly Rexulti under my insurance + the manufacturer discount card is cheaper than generic Abilify, so I want to get familiar with it. I have only had one true experience with an AAP, Seroquel, and it was actually really nice but it made me sleep like a rock, so I got off it years ago. I'm not switching to Rexulti at the moment, but my psych let me know it's the next option if Wellbutrin doesn't work out. Again, let me know your experiences with it, and I guess Abilify too since they are similar. The thought of being on an AAP scares me, with all the side effects and such, especially for depression. But I have read Rexulti and Abilify both have "pro-cognitive" effects which is exactly what I need. Also, has it helped with your anxiety at all? Do AAPs generally help with anxiety? Because if I'd be able to get off Klonopin that would be a plus. Thank you all for any replies!
  7. Hi guys, ive been on inVega sustenna for three months and my side effects are terrible on this drug. Blanking out, bad memory, lack of creativity, bad focus, slow mind and worse of all, anhedonia. Both sexual and emotional alike. It’s been three months and these things still have not lifted. I know it’s not my illness because my schizophrenia gives me heightened emotions and gets me high, and these side effects all started for the first time since I took the drug. Maintena is coming out in my country this December and I was thinking of asking my pdoc to switch to it. I heard that abilify can cause blurred vision and if you’re unlucky td, I’m scared of this. I’ve taken abilify tablet form before for around a week to a month or so at five milligrams, and didn’t get blurred vision or td, would anything change with the injection form? And also what is your experience on this drugs injection form? Regards.
  8. Not sure where else to put this one, but I took my Abilify from 15mg to 2x15mg per day a week ago. I just got back from my appointment with my pdoc (finally) and was half surprised that she didn't chew me out. That's the first *positive* med change I've made for myself in... ever? I left the rest of my cocktail alone, but maybe I should note that my Wellbutrin dose is only at 300mg instead of 450mg... that one's either the last pdoc's fault or Medicare's fault. Everything else stayed the same. New pdoc is trying to work that out also. I'm going to stick with it for a while this time. I might miss one dose a day, but missing both is less likely, and maxing out my Abilify dosage right now seems to be helping. Since making the change a week ago, I've finally left my since-February mania and sidestepped a growing delusion / paranoia break. So I think after paying attention to the various pdocs over the last decade, I might have done something right. *gasp*
  9. I will make this as to the point as possible. First time ever posting on blogs, Hoping this place can aid decisions along with psychiatrist. I was diagnosed with Depression, Anxiety, and Adhd at age 14. (22yo now) My depression has gone from moderate to bad, to severe over the years. This is not the suicidal, crying every night type of depression. This is a (Complete Lack of motivation, energy, drive, initiation,) type of depression. I oversleep and when i wake up, my life is just grey, and uninteresting. Doing anything takes sooooo much fuckin effort. I litterally cannot hold a job, or do any simple tasks. Life is Overwhelming. Past medications include, Zoloft, Wellbutrin, cymbalta, remeron, strattera, are the main ones, with little to no benefit, however strattera had the biggest impact on my energy, depression, and motivation. The issue with strattera is that the burst of motivation did not last long. An increase of Strattera equalled 3 weeks of Motivation Boost, followed by nothing (as if i never took the medication.) Had a genetic test done that shows i might react better to SNRI's rather than SSRI's. Because of my report of Strattera, my doc now Prescribed Fetzima (Works more on norepinephrine neurotransmitter). I might have Treatment Resistant Depression so he augmented Fetzima with Abilify (2mg), in hopes of them enhancing Each other. 3 months on fetzima, (now max dose of 120mg) i noticed very Minor changes. Which could indicate my TRD. Well i Indicated my depression has not improved much so he increased abilify to 4mg. Second day on 4mg and i feel as though its making my Energy and Depression Worse. I really want to stop taking abilify, however i might take it a couple more days to test it out. Here is my Main Question. Are there any atypical antipsychotics that do not cause any sedation, or one that causes the least amount of sedation compared to others? That is basically my only question actually. Feel free to chime in on how Fetzima has worked out for you, and if you have TRD, and have found the right combo that helps you. Thank You Guys!
  10. I wish I had never been placed on it adjunctively for depression/anxiety. I was first embarrassed because it is classified as an antipsychotic. I was on the lowest dose for a few months. I gain about 15 pounds. I haven't been able to return to my pre-abilify weight. So frustrating.
  11. I've been on Abilify for about a year and a half now. It has been the best AAP for me as far as mood stability and help with bipolar depression goes. But I have this nagging suspicion that it has really screwed up my cholesterol... Before I went on it, my cholesterol was fine, but not long thereafter, my cholesterol was a little messed up... I started it in August of 2017 and by October of 2017, my cholesterol was as follows: Total cholesterol: 187 mg/dL (10-199 mg/dL) HDL-C: 10 mg/dL (30-72 mg/dL) LDL-C: 129 mg/dL (0-128 mg/dL) Triglycerides: 220 mg/dL (40-160 mg/dL) vLDL-C: 44 mg/dL (5-40 mg/dL) Chol/HDL ratio: 18.70 (0.00-5.00) It wasn't terrible, I guess, as they didn't put me on a statin at the time. They just said "lose weight and diet," which I was already doing both of at the time. I just made it a point to do it more. I went to the gym and exercised, but I eventually fell out of doing that. Fast forward to last month, I had my testosterone checked because of various reasons (mostly depression, inability to lose weight, what appears to be gynecomastia), and while my testosterone is okay (which it has been low and they've said it's okay before... I have yet to get a copy of the blood test results), they said that my LDL cholesterol was "very high" and my HDL cholesterol was "very low" (I assume it hasn't budged from 10...) and that my doctor wanted to put me on Lipitor 20 mg. So he called it in and I started taking it, hoping it will make a difference. I plan on getting a copy of my blood test results, like I said, and I do plan on going back to the gym. I don't know what I've been doing wrong, or if it's the Abilify. I'm eating right, or so I think I am... Has anyone had problems with dyslipidemia from Abilify? It's supposed to be metabolically friendly!
  12. Hey there! I've been having a very difficult week. I've been on lexapro and klonopin for depression and anxiety for 3 years and the lexapro has plateaued in the last year or so, so my pdoc decided to put me on Abilify about a week ago and it has SUCKED. I'm not feeling any of the positive effects of the meds yet, which I understand because sometimes it takes a while. BUT i have been feeling a whole bunch of negatives. Theres a general brain slowness, like forming sentences and thoughts takes much longer than usual, like if my train of thought were a real train, there is now a huge parachute on the back slowing it down. The WORST side effect so far has been the derealization. I'm familiar with it as it is a side effect of my anxiety. I can't tell if it is a direct effect of the abilify or if the meds are causing more anxiety which is then causing derealization. The thing is, I haven't been feeling much more anxious than usual recently. It's like the derealization comes over me first and then the anxiety follows. Has anyone experienced this on Abilify? If so, did it go away eventually? Did you switch meds? Nothing seems real and I'm getting very very tired of it.
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