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to the OP - sorry for the thread hijacking. in my experience, everyone has a different dose that is best for them for sleep. for some - 200 may be more sedating than 150 - and the opposite may be true for others. you can only find the best dose for you with trial and error. i've heard of 400 mgs being effective for insomnia and also 25 mgs. generally, the lower the dose, the more effective it is, but that does not mean that will be your experience.

 

i was on varying doses of seroquel for sleep for years and found it very helpful with minimal side effects. i went off of it because of a problem with fatigue which was being worsened by the seroquel (not caused by it, though). 

Edited by cosima

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to the OP - sorry for the thread hijacking. in my experience, everyone has a different dose that is best for them for sleep. for some - 200 may be more sedating than 150 - and the opposite may be true for others. you can only find the best dose for you with trial and error. i've heard of 400 mgs being effective for insomnia and also 25 mgs. generally, the lower the dose, the more effective it is, but that does not mean that will be your experience.

 

 

All the previous nonsense in this thread aside (which I don't have the energy for), this is basically exactly the answer I would give to the original question.  Lower doses are generally more sedating, but this is not the case for everyone.  I may as well be popping sugar pills for any of the small doses.

 

I was also on 1000mg of the instant release for several years because that was what worked for me at the time.

 

eta I'm moving this to the Antipsychotics forum since the question really is about Seroquel.

Edited by MiaB

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Taking immediate release for sure. XR would never give me drowsiness. I basically use this because no other meds work on me.

So would 250 be more sedating than 200? This is not like Remeron, right? Where it's more sedating at lower dose.

 

anything under >200 is more sedating, If you take as well more than 800 which you shouldn't can be very sedating too. Is it normal release? Seroquel for sleep, never heard of that though...

 

Yeah it is, I take it for my bipolar, anything under 250 is given to schizophrenics as well because it's sedating, it's unfortunate that your doctor had to resort to seroquel, its a nasty drug, I hate it. It represents all the corruption of the pharmaceutical world, doctors literally give it to anyone....when it's strictly for schizophrenia and bipolar or any psychosis related illness...but if it works then yeah, although if you ever come off it you might get psychosis so be cautious. 

 

 

Hey Jimmy, I'm going to write a script that automatically tells you to shut the fuck up every time you post so nobody else has to. 

 

At doses under 200mgs Seroquel is basically an antihistamine.  It blocks H2, the same as benadryl, and that's about it.  You won't start having a noticeable effect on other receptor sites until you get up around 400 or so.   If you're taking less than 400, you're getting overpriced benadryl.

 

As you get higher, the effect on norephenphrine can make it stimulating enough to counter the effect on H2, plus you begin to develop a tolerance to the sedative effect.   

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you can tell me shut up, or someone could enlighten me and tell me why my leaflet says  different, I would actually like to know.  but you can be more polite about it. No need to swear at me. You are getting angry, not me. Don't swear at me. Thank you

Edited by StJimmy9151

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The FDA max recommended dose is just that, a recommendation.   Physicians can prescribe ten times that if they think it will work without killing someone.

 

The max recommended dose is just the max dose on which extensive testing has been done, or the max dose people could take during testing before either higher doses were no longer effective or started to have bad side effects for a small minority.

 

That doesn't mean people can't take a higher dose or shouldn't take a higher dose.  All that number means is that you can't sue the drug company if you take a higher dose and turn into a frog.

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Yeah it is, I take it for my bipolar, anything under 250 is given to schizophrenics as well because it's sedating, it's unfortunate that your doctor had to resort to seroquel, its a nasty drug, I hate it. It represents all the corruption of the pharmaceutical world, doctors literally give it to anyone....when it's strictly for schizophrenia and bipolar or any psychosis related illness...but if it works then yeah, although if you ever come off it you might get psychosis so be cautious. 

 

 

I would also like to call bullshit on this statement. There are "approved" or "label" usages of medications. And then there are also legitimate "off label" uses of drugs. 

 

What that means is that the pharmaceutical company didn't want to spend the money to run a research trial to see if it would be effective on conditions other than what the FDA has approved it for.  People get "off label" medications prescribed ALL THE TIME.

 

I would be dead if it weren't for slurroquel when I needed it, and I took it for PTSD.

 

And I have a pretty strong opinion about not being dead.

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Yeah it is, I take it for my bipolar, anything under 250 is given to schizophrenics as well because it's sedating, it's unfortunate that your doctor had to resort to seroquel, its a nasty drug, I hate it. It represents all the corruption of the pharmaceutical world, doctors literally give it to anyone....when it's strictly for schizophrenia and bipolar or any psychosis related illness...but if it works then yeah, although if you ever come off it you might get psychosis so be cautious. 

 

 

I would also like to call bullshit on this statement. There are "approved" or "label" usages of medications. And then there are also legitimate "off label" uses of drugs. 

 

What that means is that the pharmaceutical company didn't want to spend the money to run a research trial to see if it would be effective on conditions other than what the FDA has approved it for.  People get "off label" medications prescribed ALL THE TIME.

 

I would be dead if it weren't for slurroquel when I needed it, and I took it for PTSD.

 

And I have a pretty strong opinion about not being dead.

 

Well, now I know, I suppose there is a lot of bs articles out there too against seroquel, I like seroquel, it helps for sure it I gained weight with it though but it's better than being depressed.

Edited by StJimmy9151

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Antipsychotics can have major side effects, especially seroquel and zyprexa.  But they definitely are extremely useful for treating certain things.  I know people who haven't gained weight at all on these meds, althugh I'd be morbidly obese if I had to take zyprexa permanently.

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At doses under 200mgs Seroquel is basically an antihistamine.  It blocks H2, the same as benadryl, and that's about it.  You won't start having a noticeable effect on other receptor sites until you get up around 400 or so.   If you're taking less than 400, you're getting overpriced benadryl.

 

As you get higher, the effect on norephenphrine can make it stimulating enough to counter the effect on H2, plus you begin to develop a tolerance to the sedative effect.   

 

 

hi sorry to jump in, but I would like some clarification. I take antihistamines more than 20 years. When I was using atarax for sleep and without taking an antidepressant, atarax was causing me some type of nostalgic depression mainly but not only about the past, around one hour after taking it.

 

with quetiapine I have less than a year experience and never went more than 100mg (yet) but I never felt strange thoughts as with a strong antihistamine dose, on the contrary it clears my thoughts even at 50mg. So with small dose of quetiapine I have sedation with a clear head. Is it maybe cause I am relatively new to it, IDK but I don't feel I take benadryl, I would appreciate some thoughts...

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On 3/4/2015 at 3:54 AM, Velvet Elvis said:

 

Hey Jimmy, I'm going to write a script that automatically tells you to shut the fuck up every time you post so nobody else has to. 

 

At doses under 200mgs Seroquel is basically an antihistamine.  It blocks H2, the same as benadryl, and that's about it.  You won't start having a noticeable effect on other receptor sites until you get up around 400 or so.   If you're taking less than 400, you're getting overpriced benadryl.

 

As you get higher, the effect on norephenphrine can make it stimulating enough to counter the effect on H2, plus you begin to develop a tolerance to the sedative effect.  

On 3/4/2015 at 4:37 AM, Velvet Elvis said:

It's the US.  Everyone is more concerned with avoiding lawsuits than what's best for patients.  

Thank you for the information! PS nice Boognish!

Edited by hoersiamhores
Typo

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