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New study says acetyl-L-carnitine related to TRD

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https://medicalxpress.com/news/2018-07-lack-molecule-severe-treatment-resistant-depression.html

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People with depression have low blood levels of a substance called acetyl-L-carnitine, according to a Stanford University School of Medicine scientist and her collaborators in a muticenter study.

 

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Lowest levels = worst symptoms

Further analysis showed that the lowest levels occurred among participants whose symptoms were most severe, whose medical histories indicated they were resistant to previous treatments, or whose onset of the disorder occurred early in life.

[...]

But she cautioned against rushing to the store to pick up a bottle of acetyl-L-carnitine and self-medicating for depression. [...]

Big questions remain, she added. "We've identified an important new biomarker of major depression disorder. We didn't test whether supplementing with that substance could actually improve patients' symptoms. What's the appropriate dose, frequency, duration? [...]

 

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