The Scientific Method requires replication of test results, one study alone does not mean anything until it is replicated by others using the same methods and the same results are received. Metformin (Glucophage), an old diabetes drug that most Diabetes II patients are familiar with, also seems to increase or improve adult neurogenesis and spatial memory formation. This means neurological cell growth and a special kind of memory. Depression affects both or these, or they may play a part in causing depression.
Here are 2 studies confirming the same hypothesis:
I had been on Metformin 500mgs 3 x daily for about a year. I asked my GP would she put me on it as I had heard that it could help with weight gain caused by AAPs. I had been losing weight slowly while taking the Metformin alongside some exercise and healthy eating. However since I have gone of it about 6 months ago I have been gaining weight and am now the heaviest I have ever been. My clothes don't fit me and I am living in tracksuit bottoms. I hate myself for getting so fat again. I had lost 35 lbs in a year and now have gained that with another 4 on top of that and now a massive 246 lbs. No matter how hard I work at it I cannot shift the weight and am miserable.
Is there anybody else out there that feels that Metformin is helping them with weight loss. Also is there anyone who stopped taking it and gained weight again. And if anybody knows anything about Metformin and it's role in weight loss due to taking AAPs I would love to hear from you too. This weight gain is making me depressed
I've been on metformin 1000mg(500mg twice daily) for more than a week now for weight gain caused by my antipsychotic(clozapine). My main complaint was waking up middle of the night just to eat.
On metformin I've noticed fluctuating results - like my appetite is reduced on certain days and then its increased again on some days
What should i do ? I know that metformin is working on some days but its not consistent. Should i increase my metformin dose or do something else ?