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Using Trazodone as an antidepressant?

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So yes, I understand that trazodone is actually an antidepressant but is primarily used off label as a hypnotic for sleep.

Curious if anyone here has actually used trazodone as their antidepressant? If so, what was your experience? Is it truly as a covering pdoc advised, a crap AD, but great for sleep?

I've read some articles suggesting that the efficacy of trazodone is equal to SSRI/SNRIs, however, if that's the case, why is it not being used as an actual AD?  My understanding is that at higher doses like 300+ it pulls a Remeron and gets stimulating?

What about the extended release version Oleptro? Anyone have experience with that?

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It proved to be a weak antidepressant. I took it when it was a brand, Dyseryl and even 300 mg a day was not effective. It is not used today as an antidepressant as it failed miserably as an antidepressant.

Edited by notloki
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48 minutes ago, argh said:

 Curious if anyone here has actually used trazodone as their antidepressant? If so, what was your experience? Is it truly as a covering pdoc advised, a crap AD, but great for sleep?

I have never used Trazodone as a monotherapy for depression, but have been using it for years for sleep....I take 200mg every night..........IMO, by itself, it would be pretty weak as an antidepressant......I take 2 other antidepressants plus the Trazodone.

That's just my experience....

Edited by CrazyRedhead
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They make an extended release trazodone, Oleptro, that you take at bedtime and supposedly it works better than the regular old "Desyrel" trazodone. I think the highest you can go on it is 375 mg (they're ER tablets but they can be split). It's brand-name only, but there are not coupons for it, so you'd have to pay full copay... which is stupid...

If you're looking at the "-done" antidepressants, I would look at either nefazodone (Serzone), its sibling medicine, or vilazodone (Viibryd) (brand-name only).

Nefazodone has a big, huge warning about fatal liver toxicity, but have read that it's overly exaggerated. I took nefazodone briefly, but didn't really give it a chance. I took it as an add-on to Cymbalta. I only took 100 mg bid (200 mg/day). You can go all the way up to 600 mg/day in divided doses. It's far less sedating than trazodone (Desyrel). It is technically a triple reuptake inhibitor (SNDRI), albeit a very weak one. It mainly is a 5-HT2A inhibitor and α1A inhibitor. It also is a partial agonist at 5-HT1A and a 5-HT2C antagonist. It is weight neutral and causes no sexual side effects; in fact, it has been noted to enhance sexual function or block the sexual side effects of SSRIs.

Viibryd is a much newer medication. It's essentially a somewhat weak SSRI with potent 5-HT1A partial agonism. It too is not associated with much sexual side effects, but may be associated with some weight gain. It isn't noted to be sedating for most people. It does have a tendency to cause gastrointestinal problems for most people, but some people get lucky.

While it isn't an antidepressant (rather an antipsychotic), it's still a "-done" and has antidepressant qualities, Latuda may be an option. It would be likely associated with a minuscule amount of weight gain, probably but very unlikely associated with metabolic disturbances such as hyperglycemia, hypertriglyceridemia,, hypercholesteralemia, etc. When it works, it works. But some people have bad experiences with it.

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Thanks everyone. Doing pretty well right now and when that happens I get this stupid idea in my head that I’m not that bad, nor was I ever so I could totally get away with sort of an all in one that handles depression, sleep and anxiety. Ha, I already tried that earlier this year with Remeron and it was hellish. Not sure why I’d be willing to do that again vs going with the combo that is kicking ass right now. Ugh, stupid brain. Out to get me even when it’s not.

thanks again

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13 hours ago, argh said:

Thanks everyone. Doing pretty well right now and when that happens I get this stupid idea in my head that I’m not that bad, nor was I ever so I could totally get away with sort of an all in one that handles depression, sleep and anxiety. Ha, I already tried that earlier this year with Remeron and it was hellish. Not sure why I’d be willing to do that again vs going with the combo that is kicking ass right now. Ugh, stupid brain. Out to get me even when it’s not.

thanks again

I do the same thing man... I understand. lol

And NO your brain isn't stupid! It's quite the contrary! You're very bright and analytical for having these ideas!

Edited by mikl_pls
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I recently did this without realizing that's what I was doing.  thanks for the head's up, to be honest.  I'll try to be happier with what's working (we still have to do some tweaks, but I was going to ask for a change that was probably just for the sake of a change/reduction in drugs).

 

(I'm debating getting off prazosin, which doesn't fall into this tendency, because it may honestly not be needed anymore and it's a pretty low risk)

Edited by dancesintherain
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I tried it when I was IP for a few days, but agree with most that it's good for sleeping, not strong enough for antidepressant.

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