Yes, I did finally accept it, and yes, it did monumentally help and put me at peace. For years and years, I sought cures from psychiatry to taking every possibly helpful supplement out there. Nothing worked. Then one day I had the epiphany that I should just accept it like a person with diabetes has to accept their disease. And like someone with diabetes, I decided to manage it. Luckily, I found a good cocktail that manages it most days, but the cocktail is far from perfect, and I'm always aware that I do in fact suffer from depression.
What I gained by accepting it was an end to the constant searching for a cure which is likely not out there. Therapy doesn't help me at all because my depression is not situational and so there's no cure there. Now I try to enjoy the good times and no longer panic and beat myself up over the bad times.