Simba Cub

Clozapine does stuff the NO OTHER ANTIPSYCHOTIC can possibly hope to do, in good ways. It's neither an atypical nor a typical antipsychotic; rather, it is in it's own class. It was the only drug that even TOUCHED my psychosis. I've maxed out the dose to within my toxicity levels and have bolstered it up with a modest dose of Amisulpride, a typical, and between them it does the trick. Highly recommended, side effects and all! (Side effects for me were primarily sleeping 16 hours a day, eating tonnes and retaining weight).

I could have done. TBH, I can't really remember. I've essentially taken every psychiatric medication in the book, barring stimulants! Fortunately I'm on a good cocktail finally, ranging from Clozapine to MAOIs and typical antipsychotics and mood stabilisers

Might I add that Vortioxetine (Brintellix) is only intended as a second line of defence, for when two or more antidepressants have failed?

Clozapine plus Olanzapine must make you sleep 23 hours a day! Amisulpride is a more activating antipsychotic, a typical I believe. Olanzapine is an atypical and Clozapine is in its own batshit crazy category!

My main antipsychotic is Clozapine at a moderate dose. In theory you can go as high as 900mg, but everyone has an upper toxicity level, so results will vary. For me it's 350mg. I also take 150mg of Amisulpride as a top-up drug and between the two, my psychosis is pretty well managed

I know one person who was on 900mg of Clozapine... but that poor bugger was REALLY sick :(

So. I was on 550mg of Clozapine. A fair whack - 900mg is the theoretical limit with 450mg being the usual amount. Anyway, it was working, but I was very drugged up. They carried out some blood tests and damn it if they didn't show that I was being poisoned by the Clozapine. I have been brought down to 350mg which is borderline safe. I guess what I'm trying to say is don't trust written "maximums" - if you feel odd, get screened. Everyone has different tolerances and it's important to know yours.

So I've been receiving eTNS treatment for a few months now, using a NeuroSigma machine at the optimum dose of 5.0mA and it's great! You attach electrodes to your forehead and a direct current is passed between them. It buzzes a bit to start, but you soon get used to it. One dose is 12 hours so you sleep with it on. Can be a bit tricky if you toss and turn, but it works out. Couldn't live without it now! Expensive though - the machine was £1,000 and the electrodes £90 for 10, so insurance is a must.

My clinic calls it eTNS, I use the Monarch system. Promising so far. Little at a time. You have to work up your dose incrementally to the therapeutic dose. All plugged in now for the night... Buuzzzzz!

Has anyone come across Rasagiline? Activating/Sedating, half life? Richard

Massive one, called Seratis. Had a review of practically every approved drug out there for the more common ailments as well as descriptions of the illnesses themselves. This of it like a big brother to Crazy Meds. Then the hosts pulled the plug. I retrieved the site and set it up again. This time, instead of an HTML monstrosity, it was fluently put on phpBB3, searchable and indexible. Again, the host pulled the plug with no warning. Now it's gone. All that work, gone. Will I ever recreate it? I don't know. I have a blog (http://www.flyingfelix.co.uk) but that's it for now and I'm fairly content.

Well, I had three holidays planned. Vegas in May, Venice in August (birthday, yay!) and Orlando in October. Vegas? Not likely. Venice? I'm hopeful but pessimistic. Orlando? If we're not healing by then I'll be pessimistic about the state of the world

See, stuff like this gives me hope

That is a mighty number!

Interesting. There are four potential treatments for Corona Virus already in the pipeline - come in China, one I believe in England and another in, again I think, Denmark. But more amazing is that a treatment for Lupus seems to fight the Corona virus. Fingers crossed!