Will this work for (and perhaps cure) anhedonia? in Depression - Let a WHAT Be My Fucking Umbrella? (Sod You, Perry Como) Posted December 21, 2014 I am curious where you learned that adhedonia is a stress response. I have not heard that before. People experiencing psychosis are generally considered to be having thought disorders, whereas depression is a mood disorder. There are different biochemical processes involved, and it seems unlikely that a fast acting antipsychotic agent would help address what you characterize as long-term depression effects. Now how anhedonia is a stress response would be because of the fact that the ability to experience pleasure cannot just simply turn off by itself. Another area of the brain has to become active in order to turn off the ability to experience pleasure. This other area of the brain that has become active would be the stress response that has turned off the ability to experience pleasure. Which is why I am wondering if shooting myself with a tranquilizer gun or getting myself shot up at the hospital would ease up or rid this anhedonia completely.