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About notloki

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    Desert Southwest, USA
  • Interests
    cats, medicine, science, music (I have a Bachelor's of Music degree), art (generally 1850 and forward)

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About Me

Dx: Major Depressive Disorder, recurrent, in full remission, Chronic Insomnia, Nocturnal Hypoxemia, ADHD-PI, Temporal Lobe Epilepsy featuring complex partial and generalized Tonic-Clonic seizures, Dyspraxia, hand tremor, Chronic pain, Cervicalgia, Diabetes II

Dosages are a daily total.

Psyc meds: Bupropion XL (Wellbutrin XL) 450 mg, Aripiprazole (Abilify) 15 mg, Mixed Amphetamine Salts (Adderall IR) 90 mg in a divided dose, generally 30 mg t.i.d. or 60/30 mg,  Propranolol (Inderal) ER 60 mg, Eszopiclone (Lunesta) 6 mg qhs., Clonazepam (Klonopin) 1-2 mg, always qhs. Levetiracetam (Keppra) 3,000 mg in a divided dose, b.i.d., Diclofenac Sodium Gel (Voltaren) 1%, up to 4 times day, 2 grams per application. Celecoxib (Celebrex) 200 mg  b.i.d.

PRN: Propranolol 20-40 mg, Lorazepam (Ativan) 1-4 mg,  Belsomra (Suvorexant) 20 mg, Ondansetron (Zofran) ODT 8 mg, Provigil 200 mg, 3:1 CBD/THC tincture (I have a medical cannabis card), Norco 10/325 (10 mg hydrocodone)

Supps: Multi vit/min as needed, Vit. D-3 3,000 IU (higher during COVID pandemic), Hemp seed oil 2 g for the essential fatty acids alpha-linolenic acid (ALA) 900 mg, and linoleic acid (LA) 260 mg, providing the last two essential fatty acids are omega-3-acid ethyl esters (Lovaza) 4 g, providing EPA 1,856 mg/DHA 1,500 mg, CoQ10 200 mg, N-acetyl cysteine (NAC) 1,800 mg, Alpha GPC (glycerophosphocholine) 300 mg, Acetyl L-Carnitine 500 mg, Piracetam 1.5 g, oxygen 3 liters/minute by nasal cannula qhs

NAC, ALA, and CoQ10 are precursors to L-Glutathione, the major cellular antioxidant that protects against amphetamine neurotoxicity among other things. Animals predosed with these precursors and given neurotoxic doses of amphetamine did not experience amphetamine neurotoxicity. See study link below.

CoQ10 is an essential cofactor to several biological processes that make human life possible. (see "ATP to ADP cycle") Statins lower CoQ10 levels. I take Crestor (rosuvastatin).

Acetylcholine is a major neurotransmitter affecting many systems. Acetylcholine causes muscles to contract, activates pain responses, regulates endocrine and REM sleep functions, memory and cognition. It may reduce inflammation. People over 50 or those who take anticholinergics (e.g. Benadryl), sedating antihistamines, antispasmodics (e.g Bentyl), neuroleptics, antipsychotics (e.g. Abilify), phenothiazines, skeletal muscle relaxants (flexeril), tricyclic antidepressants (imipramine), disopyramide, and others have a reduced level of Acetylcholine. I take a choline supplement, Alpha GPC (Alpha-glycerophosphocholine), to assure proper acetylcholine levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/  "Potential Adverse Effects of Amphetamine Treatment on Brain and Behavior: A Review."  note-A very useful study that finds few adversities and suggests ways to minimise any neurotoxicity from medical use of amphetamines.

https://www.ncbi.nlm.nih.gov/pubmed/27766914 "N-acetyl cysteine (NAC) in the treatment of psychiatric disorders: current status and future prospects".  "The rationale for the administration of NAC in psychiatric conditions is based on its role as a precursor to the antioxidant glutathione, and its action as a modulating agent of glutamatergic, dopaminergic, neurotropic and inflammatory pathways."

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