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morpheus

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About morpheus

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    male
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    Europe
  • Interests
    Psychiatry,Neuropsychiatry, Pharmacy

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  1. No and no. It must first be absorbed from intestines,then distributed throught body and metabolized by liver to be finally extracted renal
  2. Partially works for my anxiety at 900mg/day.. maybe i need higher dose to fully control my anxiety.
  3. Both. At day i felt little sedated,but during night i had little insomnia. But I took it for 10 days only,so i can't speak about long term effects.
  4. For me reduced hand tremors from haloperidol, at 200mg day. Didn't get any side effects, its my PRN drug for EPS from APs.
  5. In addition to powerful D2 actions, flupentixol has anti-serotonergic (5-HT2) and anti-adrenergic (predominantly a1) actions, but its activity at cholinergic sites is too little to be clinically relevant (Fig. 1). It can therefore be associated with hypotension on first oral exposure and with extrapyramidal side-effects, though with gradual introduction and doses kept low, it is generally well tolerated.b Flupentixol has the greatest D1 antagonist activity of all the older antipsychotics. The significance of this is unclear for, clinically, it does not stand out as correspondingly different – apart from in one possible regard. Flupentixol has long been associated in low dose with antidepressant and anti-anxiety actions (Reiter 1969; Hall 1973; Predescu 1973; Frolund 1974; Gruber 1991). Most reports are anecdotal (e.g. Trueman 1974; Becker 2002) or find easy explanation in different dose regimes between flupentixol and comparator drugs (Wistedt 1983), but a clinically impressive antidepressant action has been demonstrated in good trials. In a two-arm non-placebocontrolled study, Young et al (1976) found that in mild to moderate depression, flupentixol had antidepressant efficacy comparable to that of amitriptyline, with greater anti-anxiety effects. In terms of quality of life, Hertling et al (2003) found that people with schizophrenia treated with flupentixol felt subjectively more relaxed and better able to deal with stress than those on risperidone. We have seen similar claims for many early antipsychotics, especially when the search for marketable indications was active (Owens 2012, this issue). However, a reputation for beneficial mood actions must surely have stuck to flupentixol longest and most consistently – perhaps sufficiently so to accept the claim as valid. This is the only older antipsychotic with UK approval for use in depression. In line with recent trends, such affective benefits have been attributed to serotonergic actions (Becker 2002), but autoreceptor effects – presynaptic D1 antagonism diminishing tonic inhibition of the transmitter synthetic enzyme tyrosine hydroxylase (or 3-monooxygenase) – highlighting as they do a prominent action of flupentixol, would seem worthy of consideration. However, the notion that flupentixol’s clinical pharmacology might allow it to be considered a ‘partial atypical’ antipsychotic (Rachid 2004) is to turn the taxonomical embarrassment of ‘atypicality’ (Owens 2008) seriously surreal. Cis-Flupenthixol binds with high affinity to dopamine D1-, D2-, D3-, 5-HT2A- and alpha 1-adrenergic receptors. • Its in vitro receptor profile differs from that of haloperidol and shows similarities with those of atypical neuroleptics. • It reduces positive and negative symptoms in schizophrenic patients as evaluated in a oneyear follow-up study. • Cis-flupenthixol shows -particularly at standard dosages and lower - a reasonable good tolerability and safety profile. • Based on these and other properties cis-flupenthixol may be classified as a partial atypical neuroleptic.
  6. Flupentixol was good for GAD,but not for OCD for me. I was on 1mg BID. and second time on higher dose - depot (20mg/q2wk) which equalls 5mg/day. Had to go off due prolactin and fears of tardive dyskinesia. Hope this helps.
  7. Partial agonist have a ability to activate receptor,but only partially compared to natural ligand ie. dopamine. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, 4th Ed.
  8. *Aripiprazole 15mg - 1tb. QAM (15mg) - /antipsychotic/anti-manic *Divalproex sodium ER 500mg - 1tb. TID (1500mg) - mood stabilization *Gabapentin 300mg - 2cap. QAM; 1cap. QPM (900mg) - anti-anxiety *Mirtazapine 30mg - 1tb QHS (30mg) - Antidepressant/anti-anxiety/insomnia *Trazodone 150mg - 2/3tb QHS (100mg) -insomnia *Quetiapine 100mg - 2tb. QHS (200mg) - insmonia *Vortioxetine 10mg - 2tb. QAM (20mg) - Antidepressant
  9. I'm trying to get off high dose Seroquel (800mg). I tried to go down to zero, but couldn't stand crazy anxiety and overstimulation. Now I take 100mg at night just for insomnia with mirtazapine 30mg. My anxiety and sleep is better after I started mirtazapine. I guess it's just Seroquel withdrawal. After few weeks Tegretol will reduce plasma quetiapine (seroquel) concentration to very low levels. So take Seroquel for now, it'll self taper,because Tegretol is strong inducer of CYP3A4 enzyme, which in turn metabolize Seroquel.
  10. Depakote double lamotrigine levels in plasma. Your lamotrigine dose should be cut in half.
  11. Vortioxetine 20mg - anti-depressant Valproic acid 1500mg - Anti-manic, mood stabilizer Gabapentin 900mg - anxiety Aripiprazole - 15mg - Anti-manic, mood stabilizer Trazodone 100mg - Insomnia Quetiapine ER - 400mg - Anti-manic,mood stabilizer,antidepressant,anti-anxiety
  12. Is it hard to come off gabapentin if I abused it? Lately I took high doses of gabapentin like 6-8 grams per day,because my anxiety is high. I slowly titrate dose down to minimize withdrawal. My normal prescribed dose is low only 900mg per day.Now reduced to 600mg.
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