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morpheus

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About morpheus

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    Member

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    male
  • Interests
    Psychiatry,Neuropsychiatry, Pharmacy

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  1. I developed nasty opioid addiction at 23, still using. As for alcohol I heavily abused it from 13 to 21,but not developed addiction.
  2. Aripiprazole 15mg qAM; - anti-manic; mood stabilizer Venlafaxine XR 225mg qAM; - antidepressant Carbamazepine CR 800mg; (400 BID) - mood stabilizer Gabapentin 900mg; (300 TID) - anti-anxiety Mirtazapine 30mg qhs; - antidepressant Quetiapine 1200mg qhs. - for insomnia;mood-stabilizer;antidepressant;anti-anxietyPRN: Diazepam 5-10mg; Haloperidol 5-10mg;
  3. Took this med for a month. Great med, but prolactin elevation was a problem, even in low doses.
  4. Glad to hear you're doing great. Valproate doses are often changed in either directions according to symptoms, often blood levels are not so improtant than clinical symptoms. For Bipolar 2 serum levels of VPA doesn't need to be very high.
  5. I'm also struggling with opiate addiction, I can battle physical withdrawal, but psycological is the hardest part for me, particulary cravings, I don't know what to do. I was refused to receive buprenorphine or methadone programm. Naltrexone made me extremely angry and violent.
  6. I also had this side effect about music, it will not fade,but you'll get accustomed to it Yes,that's a right ratio
  7. I think epoxide hydrolase aren't blocked 100 % by VPA, some CBZ- 10,11-diol are formed. But maybe, yes, CBZ itself have some inducing properties to UGT. Go figure.
  8. It's hard to say. Actually neither CBZ nor CBZ-E are enzyme inducers,but CBZ 10;11-diol which is formed from CBZ-E, but while valproate inhibit epoxide hydrolase, then there should not be enzyme induction theoretically. 1200 OXC = 800mg CBZ
  9. With initial carbamazepine therapy, hepatic enzyme induction begins within 3 to 5 days and is complete within 21 to 28 days. (https://www.mdedge.com/psychiatry/article/66146/beware-cytochrome-p450-inducers-prescribing-tips-prevent-drug-drug) So I doubt that CBZ increased clearance of brexpiprazole significantly so far
  10. Any side effects from CBZ? Actually most side effects are not from CBZ, but from CBZ-epoxide metabolite
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