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About morpheus

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    Psychiatry,Neuropsychiatry, Pharmacy

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  1. Took this med for a month. Great med, but prolactin elevation was a problem, even in low doses.
  2. Glad to hear you're doing great. Valproate doses are often changed in either directions according to symptoms, often blood levels are not so improtant than clinical symptoms. For Bipolar 2 serum levels of VPA doesn't need to be very high.
  3. I'm also struggling with opiate addiction, I can battle physical withdrawal, but psycological is the hardest part for me, particulary cravings, I don't know what to do. I was refused to receive buprenorphine or methadone programm. Naltrexone made me extremely angry and violent.
  4. I also had this side effect about music, it will not fade,but you'll get accustomed to it Yes,that's a right ratio
  5. I think epoxide hydrolase aren't blocked 100 % by VPA, some CBZ- 10,11-diol are formed. But maybe, yes, CBZ itself have some inducing properties to UGT. Go figure.
  6. It's hard to say. Actually neither CBZ nor CBZ-E are enzyme inducers,but CBZ 10;11-diol which is formed from CBZ-E, but while valproate inhibit epoxide hydrolase, then there should not be enzyme induction theoretically. 1200 OXC = 800mg CBZ
  7. With initial carbamazepine therapy, hepatic enzyme induction begins within 3 to 5 days and is complete within 21 to 28 days. (https://www.mdedge.com/psychiatry/article/66146/beware-cytochrome-p450-inducers-prescribing-tips-prevent-drug-drug) So I doubt that CBZ increased clearance of brexpiprazole significantly so far
  8. Any side effects from CBZ? Actually most side effects are not from CBZ, but from CBZ-epoxide metabolite
  9. How about pushing CBZ dose faster? When I switched from Depakote to CBZ, I withdrawn Depakote and began take CBZ 200mg bid
  10. Seroquel can take up to 4 weeks to really work. 50mg is small dose,basically a antihistamine helping with sleep only
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