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  1. Thanks everyone for the answers so far! For prolonged phases, Mirtazapine, Trimipramin and now Opipramol are the ones that I´ve tried.
  2. So friends, as a look into my recent threads might suggest, mine is a long, long story. To put it in short, I´ve a history of intolerance towards antidepressants. So recently, my psychiatrist stumbled upon the idea that all my gastrointestinal, cardiac and other side-effects could be down to the anticholinergic effects present in antidepressants. However, the worrying thing for him is that he´s aware of no antidepressant which has no anticholinergic effects. He has asked me for some time to consider the issue as for the time being, he could think of nothing to prescribe for me. I thought of asking over here, are there any antidepressants which have no anticholinergic effects?
  3. Actually, when all the trouble started three years ago, it was like that I would feel all day well, free from anxiety and 'attacks' of negativity if I happened to have slept the previously night well, and would feel like a completely mad guy if sleep was an issue the night spent. So you could argue that insomnia was the biggest or the main issue. I was least aware of these things, so I simply swallowed the pill as prescribed by my doctor. Thanks for the mention of those medicines. I´ll see if my doctor agrees to them. Don´t these cause the same side-effects on the digestive system as have been caused by the ones that I´ve mentioned?
  4. So guys, over the past three years I´ve been on three different sedating antidepressants, Mirtazapine, Trimipramine and Opipramol. All of them seem to work well but they cause side effects on my digestive system beyond my tolerance level, such as severe bloating, feeling of fullness, heartburn, interchangeable constipation and diarrhea. No medicines to relieve these issues have worked, and the heartburn and the gas seem to be so strong as to cause me heart palpitations that cannot be brought under control even by medicines. I was wondering whether there exist any antidepressants that don´t cause such severe side-effects on the digestive system that have been caused in my case by the aforementioned ones? I tried SSRI and SNRI, and they clearly didn´t cause these side-effects, but they completely robbed me of my sleep - the very reason why I started taking antidepressants at all! I need help on this, friends. Please point me to the right direction. Thanks in advance.
  5. I´ve a strange history with antidepressants, they cause me a range of symptoms like extreme inner restlessness (have lost my sense of humour completely despite being known for it amongst my relatives and friends), akathisia, tremors, heart palpitations, extreme bright light sensitivity, confusion, concentration issues, memory issues and strange psychological symptoms (insomnia, anxiety and spells of severe depression) resulting from food and medicines or supplements intolerances. Been on Mirtazapine for two years, these symptoms kicked in from the 7th or the 8th month. Although Mirtazapine isn´t a tricyclic, but other tricyclic like Trimipramin (immediate issues) and now Opipramol (had provided a 4-5 day relief before all the symptoms reappeared suddenly) have caused exactly the same issues. So I was exploring the possibility of tricyclic or even tetracyclic antidepressants having these possible side-effects on people with a weak immune system (I certainly have one). I find the mention of Trazadone interesting. Does that medicine work differently tricyclic and tetracyclic antidepressants? I wonder whether that might work for me. @Iceberg I was specifically enquiring about an SSRI because it´s advertised that they don´t have too many side-effects. However, since none of them quite works as a sedative, they may not work for me because sleep has been an issue for me since seven years. I´m really interested in the mechanism of action of Trazadone, and how different it is to tricyclics and tetracyclics. Any information is welcome.
  6. I wonder whether there´s an SSRI antidepressant also effective for sedation. From my short little search, it seems sedating ADs (Mirtazapine, Doxepine, Trazadone etc.) rather belong to other classes instead of SSRI.
  7. I was just wondering there are any. I´ve been put on Mirtazapine, Trimipramin and now finally on Opipramol (not used in the U.S mind you) - all tricyclic antidepressants, by the way - and all have caused the most horrible side-effect in the world. It may not be relevant here, but my akathisia worsens after I eat or drink anything, especially if my stomach is full. I wonder whether there are any sedating antidepressants that do not have this side-effect. Could there be a link between it and them all being tricyclic antidepressants?
  8. I´ve an update, a rather confusing one or maybe.... I won´t know. Regardless, My psychiatrist put me on Sertraline (Zoloft) and that that caused worsening symptoms of depression and insomnia. I called him and he said that unless the symptoms make me go wild, I should stick to it and see if things ease up and if the side-effects subside let´s see in 20 days. No way I can stay awake for 20 nights! I´ve tried six days and I felt like a zombie due to the lack of sleep. He is adamant on putting me on a combination of Mirtazapine and something else for daytime. Clearly not working in my experience. Yesternight, at my own risk, I tapered the Mirtazapine to 7.5 mg and had an okayish sleep (could deteriorate with time with a 50% reduction in dose). An encouraging news, I´d a morning erection (not a full blown but still way better than earlier), the early morning heart palpitations were minimum, my thinking was clearer and sharp, the akathisia was almost non-existent). Till, till however I´d my lunch. Immediately after my lunch, the akathisia is back in full force, my thinking is clouded! Where the hell lies the connection between my psychological symptoms, especially the akathisia, and my diet?! I really want my life back! Allah! I was a poet, an intellectual thinker, a philosopher, a debater, a writer, a full blown Romeo, a person who´d solve people´s problems on the phone! I´ve no idea how my fiancee is putting up with this nonsense! I don´t remember the last time I romanced with her!
  9. I forgot to add here that before I was finally put on Mirtazapine, my GP tried Citalopram. It kept my wide awake the whole night and gave me inorgasmia. Was discontinued after five days.
  10. I´m open to such ideas and suggestions of ultimately depression and anxiety triggering off such symptoms, and I went to a psychiatrist only after being convinced of it. So I don´t contest that, but my psychiatrist himself was so confused at our first appointment that he too pointed towards these being result of a possible underlying liver or heart disease, or some hormonal issue - all of which I´ve got checked and all test results came back negative. So even he isn´t sure what to make of it. When I´d depression which led to Mirtazapine, the symptoms were very classical, such as insomnia, spells of extreme sadness and constantly pondering the purpose of my life etc. Now however, it´s very rarely that, it´s just that I feel numb and disinterested in anything. Another thing that I´m experiencing now which I didn´t back then is akathisia (at pretty disturbing levels). I actually used to be almost hyper-sexual to be honest here, and it stayed that way till 17 months on Mirtazapine. In the last 7-8 months however, the libido is effected, and even if I get an arousal, the akathisia takes over and the erection subsides immediately. The food, medicine and supplements intolerance that I´m experiencing, is it really something that´s associated with depression, even if in rare cases? I´m confused.... I´m 27 by the way and have stopped Fluoxetine due to the worsening of symptoms by it - at the psychiatrist´s advice. He might ask me to see him soon though. My gut feeling still is that combining anything with the Mirtazapine won´t work. Switching over to another one altogether might be a better option, but switching to an antidepressant like Paroxetine or Fluoxetine isn´t a good alternative since they´re not sedating like Mirtazapine. Which one are you on right now, if I may know?
  11. It has been suggested by someone I know that the antihistamine effect of Mirtazapine might be related to some of these issues. Is it possible? Also, how many antidepressants are there with antihistamine effects? Are all sedating antidepressants antihistamine as well?
  12. I'm having a hell of a hard time and experiencing rather weird symptoms. Whether they've anything to do with Mirtazapine (Remeron) is something that I strongly feel but can't quite convince any doctor of. I was put on 15 mg of it in spring 2015 for depression and a severe insomnia - I hadn't slept an hour like since 25 nights back then! The benefits showed immediately within a day and surprised myself and my family. I would sleep well and be in a very happy and cheerful mood. Then however, from summer 2016 I developed some strange food intolerances; caffeine, sugar, fruits containing high amounts of fructose, yoghurt, butter and so on. Eating anything of that would cause me jitteriness and insomnia. I steered clear of those foods. From autumn last year though, a lot of those food intolerances have relented and it changed into intolerance towards medicines and supplements that I was on; the thyroid medicine for hypothyroidism, Vitamin D, Calcium, Vitamin E and could never again tolerate any new medicine or supplement. Symptoms resulting from these are, again, jitters, insomnia and a strange kind of feeling of being struck on the head, like I can't hear anything and the thinking becomes very unclear and blurred. Coupled with this is a weird sensation that if a medicine has any potential side-effect (even physical, such as urine retention), I get it at all costs. So I'm steering clear of the culprits here too. However, avoiding the culprits doesn't end my misery, it just helps in avoiding a whole new set of symptoms, because since autumn 2016 I'm under constant brainfog anyway, have heart palpitations immediately after every meal (but worst after breakfast), have concentration and focus issues, lead a life without any hobbies, wishes or desires. Nothing excites me, nothing interests me and nothing catches my attention. Leave tasks pending for months (the most unlike me habbit), have badly lost my sense of humour. My sense of humour was something that I literally used to pride on, and friends from around the world would call me to fresh up if they were having a dull day. My mind feels numb, although it isn´t as if it´s the sedating effect of the Mirtazapine because 90% percent of the nights I don´t sleep well, and on a lot of nights I feel as if I´m asleep with an awake mind! Amidst all this, although initially not effected for the first 17 months, but the libido is not non-existent. If I get them at all, my erections are very tiny and hardly last a minute. The GP who put me on it considered it to be just the effects of anxiety and depression and recommended the doubling of the dose to 30 mg. When I contested that, given that I´ve my doubts of a lot of these issues being brought upon by Mirtazapine itself, she referred me to a psychiatrist. He too strongly denies of Mirtazapine having any hand to play on it and instead thinks it´ll be best to combine it with another antidepressant for day-time. He put me on Paroxetine, boom, a flood of side-effects! Then changed to Fluoxetine (Prozac) - third day on it and having weird feelings. The heart poundings are one and is in fact making me very depressed and hopeless!
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