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  1. I've meant "Social anxiety disorder". I did suffer from seasonal affective disorder, but that is no longer a problem since I take Vitamin D3. I am skinny as fuck and quite agitated. Wouldn't Bupropion make it worse?
  2. Hi guys, I am suffering from Dystymia and SAD and have been taking Sertraline 50 - 75mg for over a year now. It helps with psychosomatic ailments and moderately attenuates the anxiety & fear. My problem with Sertraline is: It makes me an apathetic zombie, indifferent to life and very unmotivated. I have sleep disturbances, the sleep is unrestful. I've also lost quite a bit of weight and am more agitated. Besides that I have hot-flashes and palpitations on a regular basis. My pdoc said that I will have to live with the sides and that he can't do anything about it. He advised me that I
  3. Yes, but there is a certain dogma among psychiatrists to push SSRIs on everybody... for different types of depression there are different fitting antidepressant-classes, but many doctors try the "one size fits all" route... If someone suffers from psychomotor retardation, hypersomnia, weight gain, then Sertraline, Duloxetine or Bupropion might indeed be the fitting med. But pushing the same med on someone with converse symptoms might be fatal.
  4. Yeahh, I've been researching SNDRIs for the last 6 hours ^^ Many interesting molecules, but also many failures. Seems like a lot of trial and error. https://en.wikipedia.org/wiki/DOV-102,677 https://en.wikipedia.org/wiki/DOV-216,303
  5. Severe depression most often comes with sleep problems (insomnia and problems getting to sleep because of too much rumination), low appetite / weight loss and agitation. Psychosomatic ailments are mostly "digestive problems". Thus some moderate sedation is useful in alleviating those symptoms. (for example through 5HT2 and H1 antagonism or some form of GABA-mechanism, but there are certainly other mechanisms too). Too much sedation is of course counterproductive...
  6. Interesting ratios, but the affinities are weak, indeed. Would need to take a high dosage for any clinical effect. A potent selective SNDRI with some 5HT-"modulation" (agonist, inverse agonist, antagonist) and moderate H1-antagonism would be very interesting. Hope they come up with something like that in the future..
  7. That's true, but I can easily off myself with Paracetamol & a bottle of booze if I have to: http://a.co/8JP4AcV I don't need tricyclics to do it...
  8. There is a certain irony here: "Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!" "...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!" "...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidep
  9. You might wanna Clomipramine with Luvox for higher CMI blood concentrations: https://www.ncbi.nlm.nih.gov/pubmed/8666564 http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20130222/msgs/1038888.html#1038888 What medication did help you?
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