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Everything posted by Selkie

  1. Hi @browri - I haven't logged on in a while, I was visiting my gf in the states and now we're quarantined in Canada. I actually have an appointment (remote) with a brand new pdoc tomorrow, which I am really optimistic about, he has a very good reputation and I'm really grateful to finally be able to talk to a psychiatrist directly, without going through my GP. How are you feeling after a month on pristiq? I've been on effexor before, years and years ago - do you find it to feel different from that one?
  2. Sorry just saw this part! I hope the 150 is working for you. I've always felt that it's a pretty decent dose, I think I've even lamented that there's no bupropion 100XL. But of course everyone is different. I'm super familiar with the wellbutrin chewing. Weirdly, it started for me when I was on the med in like, 2018, and I stopped because it was so bad - grinding my teeth in the daytime almost like a tic. Didn't really go away. Now it goes away when I'm ON wellbutrin and comes back when I'm off, which I can't figure out. Usually only flares up during extreme anxiety/stress, and I can mostly get it under control with breathing etc. I found buspirone completely useless for anxiety or anything to do with mood, but fwiw a low dose (I think 15mg/day) did cut the bruxism from wellbutrin.
  3. This is really helpful, thank you. My mom almost definitely would have been on it with an SSRI, but I will ask her. If I'm understanding right, you think that without an SSRI on board, the weight gain might not be such an issue on something like abilify? Sadly I had to pause bupropion for now. It was giving me really extreme obsessive thoughts and 2X daily panic attacks. My GP has finally, after years of asking, referred me to a psychiatrist who hopefully I'll be able to see regularly, rather than always going through the one at my doctor's office, who also refuses to think outside the box and listen to me. I'm considering that a low dose antipsychotic or mood stabilizer on its own, or maybe with bupropion again once my major anxiety triggers are a little bit more managed could be good. I just can't do an SSRI or SNRI ever again (mostly due to being put on them starting around age 13, and then throughout my entire teens and early twenties, and feeling traumatized by the way that affected sexual development, and....the unforgettable effexor withdrawals due to being a disorganized teen), and I want a pdoc who will respect that. So fingers crossed. Also curious about what the neuro-chemical difference between a mood stabilizer and an antipsychotic even is, if you have the energy to break that down for me? As always, thanks so much. I hope you're feeling well. ❤️
  4. @browri thank you so much for the update! I don't check this site too often, but I'd be curious to hear what you landed on! Right now I'm still just on bupropion xl 150, and clonazepam prn for anxiety, which I'm taking at least once and often twice a day. Long term goal for both me and more so for my doctors is to get the clonazepam to be closer to a couple times a week, but at least my doctors are understanding that maybe the pandemic isn't the best time to make such a change. I had a consult with the pdoc who works with my doctor on Thursday... He thinks I should stay on the bupropion more consistently (I tend to start and stop taking it more often than is really advisable), and find a good, tolerable augment for anxiety. His main suggestions were just adding a classic SSRI - I've been very very anti SSRI/SNRI for myself since they all seem to cause what I consider intolerable sexual side effects. I think also because I started taking them when I was a teenager (paxil around 14 I think, effexor 16-20 or so), and I didn't know about SSE, I just thought I was "broken". But he said that since I've never tried an SSRI *with* bupropion, it's worth seeing if it would counteract these. I'm still nervous, especially because I have a new girlfriend, lol, but he's right that if it would just cut the anxiety and the bupropion would do its thing for SSE, that would be great. His second line recc was abilify, which I know my mom took and loved the effects of but had very significant and rapid weight gain. Seems common. However, the wellbutrin might counteract that too. I just have heard really mixed things about this drug. Lamictal he didn't seem to keen on for anxiety, but I think they'd let me try it if I was really adamant. A big problem for me is that I'm very anxious to start new meds, I often go fill the prescription and then never take even one pill, so my doctor said she wants me to wait until I'm ready to actually give something a try...oof. I might need to bring that up with my therapist and work on a plan to get me to actually try a new drug 😕 ....is there a med that you can take to make you not scared to take new meds, lol. Anyway thanks so much for your support, this is nice to be able to talk about. I'm in some facebook groups for meds, but no one is going into nearly this much depth. I hope you're finding something that works for you! ❤️ Oh oops I saw your last post was just on Wed! I guess you're still checking out the 30mg mirtazapine... I hope it's still feeling good!
  5. @browri - I am still waiting for my next appointment. I live in Canada, and it's very difficult to actually get to see a psychiatrist, I have to talk to my family doctor and then she talks to the pdoc, but I requested a direct consult with him since I haven't had one in over a year, and my symptoms have changed drastically during the pandemic. In the meantime I've actually gone off wellbutrin because my anxiety was getting so bad.... but now my motivation and energy are totally shot. I really wish this wasn't the tradeoff, I love the way wellbutrin gives me focus, energy, patience, positive outlook etc. But I was finding I was getting even some pure O OCD symptoms which I haven't really had in many years (like, since childhood....so that's weird). I feel like your remeron/bupropion combo sounds really promising - how are you feeling on it now that it's settled in again? It's super interesting to read about the way the drugs are and are not complementary - I feel like my main doctor (GP) is just like "buspar is for anxiety so it will lessen the anxiety of wellbutrin", but it seems like that's not really accurate. Honestly you have more knowledge and care than any doctor I've ever talked to! When you say if I switched from wellbutrin to lamictal I'd feel quite different...what do you mean by that? Or like...how I'd feel different?
  6. @browri OMG thank you, I missed this alert, going to have a thorough read now - I appreciate this so much!
  7. Yeah that makes sense. FWIW I wasn't thinking of stopping the wellbutrin and starting lamictal at the same time. I guess I really want to try lamictal because it's different from anything I've taken, weight neutral, seems to have a pretty low side effect profile (other than "the rash") and although it's not first line for anxiety it seems to have good off label reviews for anxiety and unipolar depression....just one of those things where I feel like "I want to try that med" but don't have enough backup or evidence to advocate for myself w the doctor. Thanks for the help and listening 🙂🙏
  8. @Iceberg is there a reason for gabapentin over lyrica ? the doctor said that lyrica is basically a newer/less side effects version of gabapentin...
  9. LOL wow yes edamame would be a bizarre se indeed!!!! Thanks for the extra tag )
  10. Also curious about augmenting with a tricyclic ? (I am done with SSRI's SNRI's so those aren't an option)....Can anyone explain or point me to a thread that helps explain why tricyclics have fallen out of fashion/what the big differences are between those and SSRIs?
  11. Thanks @CrazyRedhead, I take clonazepam too but my new young GP doesn't want me to keep taking it, which is really annoying, and so we're trying to find something else 😕
  12. As ever if @browri or @mikl_pls has the time and energy to chime in I'd love to hear about the pharmacology of these 3 options! But also no pressure if not, of course!!!
  13. Hi again everyone, I'm looking for an augmentation strategy for bupropion XL 150, which helps tremendously with my depression, but worsens anxiety (GAD/obsessive worry)...I had OCD as a kid and I find bupropion brings up some of those old symptoms, mostly thoughts not compulsions, but I don't want to go off it because I love what it does for my mood, motivation and patience. I don't have access to a regular pdoc but there's one who works with my GP who I've requested to see, but usually my GP just prescribes and clears things w the pdoc. Last time I saw him the pdoc suggested buspar, which I have tried for a number of months at 20 then 25 mg/day and it doesn't seem to do anything for the anxiety, helps a bit with bruxism though. His other suggestions were remeron but I'm super afraid of weight gain or lyrica/pregabalin, which sounds like it has a lot of weird side effects like edema and cognition stuff. I'm an artist and I am especially reluctant to try anything that dampens creativity and thinking. I've been curious to try lamictal for a long time but my GP is always like "you're not bipolar", but I know lots of people do take it for unipolar depression....any chance it would help with anxiety? I would be open to either augmenting or replacing the bupropion w this one... Any thoughts would be so helpful!!! Thank you!!!
  14. Hi there all, I'm currently taking wellbutrin 150xl/day, as well as 20mg Buspar....I've posted about this before but back at it: Wellbutrin helps my depression a lot, but does amp up my anxiety a little bit, I have anxiety anyway and it's not so much worse that it feels like I should stop the wellb...but it's definitely there. The buspar is supposed to be augmenting it but as far as I can tell it does....nothing. Talked to my doc yesterday, she suggested upping the buspar to 30/day, which I am going to try. Her next recc was lyrica - kind of confused about this med? Does anyone have experience with it for anxiety? Would love to hear experiencess!!! Thanks so much!
  15. Wow, this is all so fascinating!!! Thank you so much for sharing your knowledge!
  16. Thank you so much @browri, this is super helpful and also very interesting! I love that you have all this knowledge. I'm curious about lamictal's similarity to ketamine in terms of being glutamatergic - lamictal is one of the drugs that also appears as being contra-indicated for ketamine treatments (infusions, or in the case of the clinic I'll be going to, sublingual). Is that because it would just cause an overflow of glutamate? I don't take lamotrigine but it's one I've been curious about for a while, interested in to what extent it's going to work similarly to the ketamine treatments. Again, thanks so much!
  17. Hey thanks @Iceberg , after reading as much as I can find, I have decided to wait. The thing is there's not a ton of research about it, so since it's safe they just say it might affect the ketamine's effectiveness, but they don't really know to what extent, and since it's safe they just say go ahead with it or not take the klonopin 24 hours before, but I can't really do that right now. I don't have a regular pdoc, I live in Canada, where psychiatrists are really hard to get access to, I have a GP who works with a psychiatrist as part of their network, but it's impossible to actually talk to him, always have to go through my GP.
  18. I've talked to the clinic about it, but my point of contact there is a psychotherapist and nurse, I had a screen with the pdoc last month. To be clear, it's absolutely safe to take these meds together - that's confirmed by all literature, the pdoc, the nurse. But they all also say that taking benzos concurrently might mean I don't get the full effects of the ketamine. I'm trying to figure out the science behind this, and how significant it is. The treatments are $600 each and they recommend six of them, and this isn't really something I can afford to have a do over with. So I'm just trying to figure out of I should wait or not. Not concerned about safety, as that's all clear. Thanks for your replies
  19. Hi, I'm looking for some insight into the interaction between ketamine and benzos, specifically clonazepam. I am on a clonazepam taper right now, currently at .75mg/day down from 1.5mg. I have read that benzos can dampen the affects of ketamine (for depression), but most of the websites as well as the clinic where I'm set to go next week say it's "not that big a deal" and that it's better to still come than not, while on the benzos. I'm wondering to what extent this is true - ketamine therapy is of course extremely expensive, and I don't want to waste it if it's not going to work - or work significantly less well - bc of the clonazepam. I know this all has something to do with glutamate, but I can't really figure out the science, let alone how significant it is, and if I should wait until my taper is lower, or over altogether, to try the ketamine treatment. Or if it's still worth it to go ahead with it now. Additionally, any chance the ketamine could make this taper any less awful? Looking in the direction of @mikl_pls , @browri & anyone else who might be able to shed some neurotransmitter-genius light on this for me. Thanks!!! ❤️
  20. @Sync thank you so much - would you be open to me messaging you about this (SSRI + buproprion and SSE)? Everyone else: interestingly, I'm on 150mg wellbutrin now and I actually can't feel it at all and am considering trying 300mg. I am also taking 25mg buspar, which I think might be helping with the bruxism/slightly anxious edge wellbutrin has given me in the past. I experienced *day* bruxism, kind of like a tic, and I'm really glad it's not bothering me this time (yet). Wondering though if the buspar is dampening the beneficial effects of the wellb. Going to talk to my MD tomorrow. Thanks so much for all of your help
  21. Thanks @notloki this is helpful ---- just to say that no matter what the manufacturer says, 150xl is strong for *me* ... I'm super sensitive to meds generally and often have gotten effects from sub therapeutic doses, go figure. Anyway I'm going to give 150 a try again for now, it's been a couple years. All the best
  22. @mikl_pls thank you so much for taking the time and care to answer this. I'm having a phone call with my GP later this morning to talk about meds. Right now they've put me back on wellbutrin 150xl, 15mg buspar (so far doesn't do anything..) & .5 mg clonazepam prn (helpful but would prefer to transition away from relying on benzos. The pdoc that works with my GP recommended Lyrica/pregabalin for anxiety. I'm also thinking about asking to try Lamictal, I've never been on it before but have a lot of friends who have had success for unipolar depression/anxiety. You are clearly very very knowledgeable - any info / insight on either of these? Thank you & hope you're well....very difficult times right now ❤️
  23. Thanks @saintalto! I def am not planning on doing anything without doctor's guidance, (except maybeee cutting tablets in half) - I don't have any of these meds atm so would need to get new rx's anyway.
  24. Hi there, hope everyone is doing okay, this is truly a challenging time for mental health, basically been working for the past 10 years on *not* self isolating. I used to take Wellbutrin 150XL, and it worked well but caused bruxism and a bit of increased anxiety. I also liked Trintellix but it caused sexual side effects (not as much as other ssri's but still more than I wanted to tolerate). What I want to try is taking a low dose of Trin (like 5mg) w a low does of Wellb (75?) Covid 19 is giving me a major upsurge in anxiety and depression symptoms, and I am wondering if anyone has any advice on how to take a lower dose of wellbutrin. I know the governing logic says not to cut XL tabs in half, but I also read somewhere that the extended release for these particular tablets isn't due to the coating, but is distributed throughout the pill. But it was just something I read on one reddit thread so...grain of salt. But if anyone has anecdotal experience with this I'd hear it! Or - IR tabs? SR? Thanks everyone & stay safe ❤️
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