I too have the MTHFR gene variant and found your information to be really useful. Wellbutrin I found to be activating and caused irritability and full blown panic attacks. I had taken it years prior for 6 months and found it to just be stimulating then, however, the same dose (150) 8 years later placed me into an anxious, irritable nightmare with periods of high energy. Increasing the dose, required me to take a couple days off work while I slowly decreased and discontinued the drug. People only noted I was irritable and spoke way more than I normally do at work, but inside I felt like I wanted to explode trying to keep everything in order to keep it together. Funny how medications can turn on you, or your biology turns on medications.