Just wanted to add my experience on brintellix (trintellix in some regions).
I noticed a clear lack of effect from cigarettes for a bit, but it passed for me. (Not sure if it has been investigated for smoking cessation)
Some foods take on a weird and not very pleasant taste. This did not pass for me.
Reading back through my journal I also noticed some headaches, although I'm not sure how much brintellix added to it.
Didn't do much for my depression, and still had me taking naps during the day.
Keep in mind that these were my reactions.
I hope it works out for you,