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  1. https://en.wikipedia.org/wiki/Clomipramine#Pharmacodynamics Scroll down. "Clomipramine is the most potent SRI among the TCAs and is far stronger as an SRI than other TCAs at typical clinical dosages.[66][67] In addition, clomipramine is more potent as an SRI than any selective serotonin reuptake inhibitors (SSRIs), it is more potent than paroxetine, which is the strongest SSRI.[59] A positron emission tomography study found that a single low dose of 10 mg clomipramine to healthy volunteers resulted in 81.1% occupancy of the SERT, which was comparable to the 84.9% SERT occupancy b
  2. Anxiety (generalized and social), agitated states, depressive states, possibly some form of mixed affective (BP?) disorder...? I've been on Sertraline for two years. Results were somewhat "meh". Was good for psychosomatic ailments and helped with cognition and derealization, seemed also quite good as "relapse" prevention, but caused typical SSRI-apathy & indifference... not sure if id did anything for anxiety, seemed like rather very subtle help... I missed some sedative and appetite-stimulating properties. (I am a skinny agitated fuck).
  3. "Best" as in being effective with fewer side effects. Which ones were the best for you? Which ones did you take? What condition(s) did you treat? What side effects did you get? How did the antipsychotics compare to "conventional" antidepressants? Can antipsychotics be an alternative to "conventional" antidepressants? What are the risks? What are the benefits? Do they make you a tomato with time? Psychiatrists prescribe them more often in recent times, it seems.
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