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  1. Hi everyone I have serious Bipolar II depression, and my pdoc recently put forth the idea of trying a new drug, Trintellix (Vortioxetine). It hasn't been on the market for very long, and as the old adage goes, "Wait for a new drug to be out for 7 years before you take it." Well, this one has been on the market for 3, so I'm trying to learn more about it and I'm having a hard time finding anyone who's actually taken the drug. My main concern is the number of receptors it hits. First-generation anti-depressants typically only hit 1 receptor. Newer anti-depressants, like Effexor, hit 2.
  2. Just thought I would share some experience with Trintellix. I started 2-3 months ago on 5mg. mainly for anxiety and depression. I also take a variety of meds to help me sleep. Trintellix can be really nauseating when you start (for at least two weeks) When I moved up from 5mg to 10mg - I became comatose. So, I went back to 5 and it's been great- It' gives a little boost of energy- similar to vyvanse. It helps me not to go home and cry everyday. :-) I seem to eat less- in terms of general snacking. What I have found with this med - is even at this low dose- you metabolize alcohol more
  3. Hi everyone, I have been on effexor for about 15 years - up and down between 75 and 225. I thing it has done it's course - i have no motivation and don't get that 'well being ' feeling that i had before meds and when i first started E. I have tried to come off a few times and get slammed with anxiety and depression in an increasingly short period of time - the last time it was 2 weeks off. I am a little worried it is withdrawal from E rather than return of depression - i could never understand why it was happening in shorter periods every time i came off. Last visit when i talked
  4. hello, new here. i found the board by googling two of my meds interactions. went to my psych today and got a new med... read about two of my meds interaction and lowkey i'm terrified lol. list of all drugs/substances i take once a day, all in the morning: 300mg bupropion qd 400mg lamictal qd 10mg generic zyrtec "women's" multivitamin 5000mg biotin birth control pill as needed: 30mg zenzedi OR adderall. i only take half at a time, and not every day, though i do most days 5mg ambien (take ~5x a week) my depression has been ter
  5. I have no idea if I'm doing this right so bear with me: I have GAD and OCD (such a lovely combo) and I just got prescribed Brintellix to help me get out of the recent anxiety/panic hole I've dug myself into. I've been on every SSRI under the sun (I was diagnosed with this shit storm of anxiety, panic attacks and OCD when I was 11 and am now currently 31) and have had great success through the years with Luvox. Then I made the "mistake" or thinking I could live without it and stopped taking it (with my psychiatrist monitoring me) and now I can't even go to the mailbox without panicking. Al
  6. Hello, I'm on Trintellix/Brintellix (Vortioxetine) 15mg and Valdoxan (Agomelatine) 25mg. I've got a history of being very sensitive to side effects and have tried a ridiculous number of medications. Currently I'm having sexual problems which have the potential to ruin my life and my beautiful relationship. The conflict I'm going through is of course that depression can ruin my life also so I'm very very torn. Does anybody have any idea which is more likely to be causing the numbness in my clitoris out of Brintellix and Valdoxan? I'm willing to put up with side effects within reason, but not th
  7. Hi I am new to the forum. I have been taking Zoloft and Ativan for just over 10 years now. I moved out of state and my new PCP agreed to take over my psych meds. He told me that if I was still needing the Ativan that the Zoloft was't working. This combo has helped my horrific panic disorder for 10 years and I have been afraid to try anything else. Unfortunately the Zoloft has made me gain 85+ pounds over the last 10 years. I really want the weight to come off and tried going on Viibryid. Viibryd didn't cause panic attacks but has made me extremely angry all the time. I decided to swich
  8. I was diagnosed with major depression/TRD/GAD/Depersonalization disorder and have yet to find a medication that works. I was prescribed Trintellix and have been on it for about 16 days so far at 10mg. I have been on many AD meds including SSRI/SNRI/MAOI/TCA's Anti psychotics etc etc. None which helped my mood or anxiety. Every time I started a SSRI it seemed it would give me dysphoric hypomania symptoms which I eventually had to stop. (New psych doctor thinks it’s truly major depression and not bipolar disorder mixed state, like they once believed) So far, my experience with this med has
  9. So, I'm figuring out that based on my research of this medicine.. There aren't enough people who really took the time to break down a day by day timeline of how this med has helped or hurt. Seeing as this is my 3rd day on it I figure why not be that guy. Brief history of how I got here. I am 31 years old and have been struggling with anxiety, gad, panic attacks for the last 10 years or so. When this first started happening I never knew what It was and would always be able to make it go away on my own by blocking it out. Eventually it got more frequent and I was concerned about my
  10. I work in a doctor's office and the drug rep informed me that Brintellix is being renamed Trintellix due to name confusion with another drug. This probably will happen in June. Just a heads up.
  11. Was finally doing well on Brintellix for about 2mths then had random panic attack out of no where. Anxiety/depression never left afterwards. Doctor is considering that I have bipolar but is not yet ready to give that DX and wants to treat the recent anxiety relapse as just that Anxiety. So she has recommended Buspar. Anyone take this combo? Also looking for just side effects of Buspar. I have read that it can cause rage... That scares me. Almost to the point of not wanting to try it since I am home for nearly 50 hours a week with my 2 little ones ages 2-4. If I did anything to hurt them....
  12. How long has it taken for Brintellix to kick in for you? I just finished week 3 at 10 mg and have now been upped to 20 mg, with a corresponding drop in Wellbutrin. I have seen some improvement, but hope for more, and the side effects have been negligible. I have been in a really resistant depressive episode for the last several months. I have found the 58 page Brintellix topic here to be overwhelming, so I'm hoping others will post more specific info and start more topics. I realize it's a newer drug so there's not that much experience to report on yet.
  13. i've been on the 20 mg dose for a little over a month now. not really seeing any signs of improvement at all. i know YMMV but i'm curious to see how long it took to make a difference barring any side effects and whatnot for other people.
  14. Hi all, Is anyone else lost all appetite on Brintellix? First couple of days I was extremely nauseated and simultaneously starving. It was weird. Then later, I had a few days of really, really bad reflux/feeling nauseated (but it's possible that was due to something else). But now that I'm a few weeks in, I'm barely interested in food. I forget to eat. And even if I have something really delicious to eat, I'm barely interested. I don't mind too much. It's better than being nauseated. I just have to make sure that I eat regularly whether I feel like it or not. I was just wondering if anyone e
  15. I've been on Brintellix since October. We did a trial of 30mg of brintellix this last month. Started Buspar in March and she also increased the dosage of that to 20mg 2x day this past month. I have seen slight improvement but doctor doesn't seem to think it was enough. SOOO she wanted to drop me back down to 20mg of brintellix and start Lamictal starting at 25mg. my current DX is Depression and Anxiety. Though she has said she was monitoring me for signs of possible slight bipolar tendencies. She didn't mention anything today about the bipolar... Just said she thinks the lamictal might be a
  16. Brintellix was added to my cocktail about 5 weeks ago to try to pull me out of the depressive episode I'm currently in. I started at 10 mg and went to 20 mg after 4 weeks. It's giving me terrible insomnia, even with taking Ambien CR. Have you experienced this, and did it finally go away at some point?
  17. Hi fellow friends, I've been on 10 mg Brintellix for one week. I really like it, feel calmer...but no pooping now for 4 days straight( Doc ordered me to stop for awhile..has anyone had experience with this side effect, and can it go away? Thanks, blessings!
  18. I need some advice on Wellbutrin withdrawal. I've been on Wellbutrin for over 10 years, with various other meds added in here and there. I had a good long 6 year remission on Wellbutrin + Lamictal, but then went into a depressive episode last November, and it's been resistant. My Wellbutrin dose was increased from 300 mg to 450 mg, then Abilify was added, which made me better, but not well. A couple of weeks ago Brintellix was added to the mix and the plan is to up the Brintellix from 10 mg to 20 mg (the therapeutic dose) and start reducing the Wellbutrin. The Brintellix increases the action o
  19. I've been in a BP II depressive episode for several months that got a little better with the addition of Abilify, but not much. It's taking everything I have to barely function, and if I wasn't lucky enough to be working from home I would have been fired by now, as getting up and getting dressed every day is beyond me. I've been on 450 mg of Wellbutrin, and the pdoc just added in 10 mg of Brintellix, with a follow up appointment in 3 weeks, at which time we'll reduce the Wellbutrin by some amount. The pdoc also had me reduce my Abilify from 10 mg to 5 mg, starting now at the same time I starte
  20. I saw My pdoc this past Monday. I had been taking the marketed max dose of Brintellix (20mg) since Jan of this year. I felt it was helping just not enough and I guess you could say I have a phobia of trying new meds. So she decided to go off label and increase my dose to 30mg. She said she has a couple other patients at 30 and 40mg with great results. I really had no start up symptoms expect flatulence, which has come back. Wondering if any others here have had their dr go above the recommended max dose on brintellix (or other meds) with success or was it a disaster.
  21. I've been on full dose of brintellix since January (started it in October '14) I thought it was doing wonderful for a couple months then just crashed. Had a few rough weeks, back to being great, then a lot of just ok days, an occasional great day. But lately the bad days are coming more often with the gap of ok days shrinking and the great days being few and far between. I am scared to death of antidepressants due to a bad run with tons of them when I was a teenager. It took me months to even get the nerve up to try this one. It has been easy on me. very few side effects and the ones I have h
  22. New user here. I have had a driving phobia since I had my child four years ago. Recently it has gotten a lot worse and I can hardly drive at all. I am working to get into a psychiatrist but in the meantime my dr. gave me brintellix to try. (5 mg). I have not taken it yet and have never been on a drug for my disorder. I am actually afraid that it will make me feel worse. Any words of wisdom for me?
  23. I've been on a number of depression meds for 15 years. After trying a bunch of different ones I finally got on Abilify with a fair amount of success. It was added to a few other meds and has helped bring me out of a nasty depression 8 years ago. The other meds were lamictal, lexapro, and wellbutrin. The major side effect I had from this cocktail was sluggishness. I had no energy and significant lethargy so after 8 years of this I decided to remove the Lexapro. The result has been fewer sluggishness and more positive emotions (like tearing up from joy or getting chill bumps after hearing
  24. Day 5 of 10 mg of Brintellix. I got the dizzies 2 weeks ago while tapering off my Lexapro 10 mg, figured that was a normal side effect of withdrawal. But day 5 of B here and I am so dizzy I literally cannot stand up without feeling like I'm going to fall over. Anybody else have/had that? thanks!
  25. I have been on Brintellix since October. Started helping with my depression but not my anxiety. Went to 20mg in this Jan and very shortly was completely off my benzo's Was loving life, enjoying things... Then friday BOOM panic attack friday night, followed by they anxiety and depression came storming in to settle down.. SO anyone have this issue with this med? after a few months FINALLY starts working only to have it crap out on you a couple months later? ANy suggesions on what to do next. I have an appt with my pdoc in 2 days. I do have SEVERE med anxiety. I had this script for 3 mont
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