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Found 8 results

  1. https://en.wikipedia.org/wiki/Amitriptyline https://en.wikipedia.org/wiki/Nortriptyline Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite. When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition) What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically) binding affinities: picture source: https://abload.de/img/nortgpk1f.png
  2. Link: NIH rat study suggests amitriptyline temporarily inhibits the blood-brain barrier, allowing drugs to enter the brain "a provisional patent application has been filed for methods of co-administration of amitriptyline with central nervous system drugs." I can't help but wonder if amitriptyline will become a brand-name only drug once again or something, or if some generic drugs for these aforementioned CNS conditions will be paired with amitriptyline to form brand-name combination drugs and be pushed for profits. But still, this is a pretty neat discovery. Regardless of what happens with patents and whatnot, hopefully, amitriptyline and any generic drugs for any of these conditions will remain separate and generic so that they can just be prescribed separately and taken together to achieve the same potentiating effect as a 2-in-1 drug. I understand that research hasn't been done on humans, but I'm curious about what dose it would take for this to happen for humans. It doesn't mention the dose used for the rats, but I wonder if just a low dose could be used, like 10, 25, or 50 mg, or if it would take higher doses like 150-300 mg, or supratherapeutic doses above 300 mg?
  3. Has anyone here who has a history of weight gain from antidepressants had success with a very low dose of Amitryptyline? I'm hoping 10mg will not cause weight gain. And I also hope 10mg won't cause sexual problems. Weight gain is something I'm terrified of after becoming huge on Zoloft.
  4. Hi Folks - I have been trying to pull some stats on the effects of Amitriptyline vs. Nortriptyline on norepinephrine reuptake (NR). What I am seeking to understand is whether Ami's effects on NR are less than Nori's? I have read snippets of conflicting literature, but in all most have been pretty vague on the whether it is less, more, or equal. Issue at Hand: I tolerated several - Lexapro, Zoloft, and Prozac - SSRIs pretty well, albeit sufficiently therapy at lower doses than for most, for depression prior to this period of migraine hell - specifically Migraine Associated Vertigo. I have trialed Effexor and Nori (now) and they have been equally difficult to tolerate with heart side effects, I am thinking due to NR. I have had more success with Nori though and was hoping that maybe Ami had lesser effects on NR and the heart, so it might be a better avenue for me to pursue. I understand about titration - low and slow method to tolerance. Thanks
  5. Hi Folks - I have been trying to pull some stats on the effects of Amitriptyline vs. Nortriptyline on norepinephrine reuptake (NR). What I am seeking to understand is whether Ami's effects on NR are less than Nori's? I have read snippets of conflicting literature, but in all most have been pretty vague on the whether it is less, more, or equal. Issue at Hand: I tolerated several - Lexapro, Zoloft, and Prozac - SSRIs pretty well, albeit sufficiently therapy at lower doses than for most, for depression prior to this period of migraine hell - specifically Migraine Associated Vertigo. I have trialed Effexor and Nori (now) and they have been equally difficult to tolerate with heart side effects, I am thinking due to NR. I have had more success with Nori though and was hoping that maybe Ami had lesser effects on NR, so it might be a better avenue for me to pursue. I understand about titration - low and slow method to tolerance. Thanks!
  6. Hi. I've been on 20mg ami since fall 2015 and have since gained 20 lbs . I'm going to my doctor soon and will likely change meds, but does anyone know if the pounds will just melt off or if I'll have to diet to get rid of them?
  7. Curious on the meds im being prescribed. Whats is anyones take on them. My first go around with some of them. Any advice? Current cocktail Celexa Clonzepam Vistaril Amitriptyline Phenergan Fiorcet
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