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This is more of a poll to see everyone's favorite med that augments Ritalin? Unfortunately, I don't have access to Adderall, Dex, or any other stimulants (not available/authorized here). So..... I'm debating on switching out my A/D... I'm leaning towards going back to Effexor. My pdoc also suggested Abilify to augment, but seems that would be counterproductive, I'm not thrilled about the side effects.

I've been reading the following articles: https://psychotropical.info/clomipramine-potent-snri-anti-depressant/ https://psychotropical.info/tca-intro/ https://psychotropical.info/snri-intro/ Seems to be a pretty potent drug: SNRI, antagonist of the alpha1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system; so that speaks for itself. The reviews on drugs.com and other sites also are quite positive. The following ranking is interesting: http://slatestarcodex.com/2015/04/30/prescriptions-paradoxes-and-perversities/ These numbers are based on aggregated patient ratings. Top 4 drugs: # Nardil 1.25 # Parnate 1.23 # Chlomipramine 1.22 # Emsam/selegeline 1.07 => Clomipramine roughly on pair with MAOI, followed by Nefazodone (R.I.P) and Imipramine. Imipramine is also a potent SNRI, but lacks the strong 5HT-antagonism compared to Clomipramine. I suppose that's the pharmacological difference which makes Clomipramine superior... ? Clomipramine exhibits some antagonism of dopamine D1, D2 and D3 receptors... can one expect some clinical & therapeutic benefits from this? Clomipramine acts as a functional (potent!) inhibitor of acid sphingomyelinase (FIASMA): http://en.wikipedia.org/wiki/FIASMA Some interesting graphs regarding antidepressant FIASMAs: http://d-nb.info/1011278227/34 Who here has been on Clomipramine and what were your experiences with it?

So Effexor XR is the best medication I've taken for my problems which combined anxiety disorders, panic disorder, and obsessions. It has also helped with depression that inevitably follows these... So I know the SSRIs/SNRIs are notorious for this side effect, I was just wondering how other users deal with this problem as this can be difficult to talk about with peers and even doctors? I don't even like posting this here, I just don't know what to do. I was on Effexor XR for about 5 years at 300mg, last year I came down to 150mg, and currently I'm on 75mg. Luckily I've felt pretty stable and been maintaining well. However, my libido has been transient and pretty much nonexistent at times. I've tried several things, from abstaining for weeks at a time to OTC libido boosters....Oddly enough I felt my libido was actually higher on high dosages of the Effexor. Possibly to do with the Norepinephrine/Dopamine push? Anyways I asked my Pdoc about it finally and he said he script me Viagra or Wellbutrin. Neither of which I'm very fond of doing. I have a bottle of Wellbutrin sitting on my dresser right now that I haven't started yet because I've heard it can make anxiety issues worse and the fact I could be adding another side effect (truthfully I don't want to start another medication and go through that again) The Wellbutrin is a last resort right now....I don't feel like I should be having these issues at 34 and it has been very distressing as you can imagine... So I'm asking people out there how they dealt with sexual side effects on Effexor, post-effexor, or on other SSRIs if you've had experience with the Sexual side effects? Is the only option to stop Effexor to remove this side effect?

Hi Everyone, Yep, I did it. I am indeed an idiot. I forgot I took my 11am 40mg Celexa yesterday morning and took another 40mg at 2pm. Then I forgot I did THAT and took my regular 11am dose this morning, so I'm hurting. Weird nausea thing happening in my head right now, but I don't think it's bad enough to go to the hospital. Anything I can do other than wait it out? I've got so much work to do. I deeply appreciate any help. LMN

Welbutrin (Bupropion) is a dopamine-norepinephrine reuptake inhibitor; its occupancy at dopamine transporter (DAT) is 23%; whereas over 75% causes euphoria (ex. cocaine). A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron. This results in increased extracellular concentrations of dopamine and increase in dopaminergic neurotransmission. I am currently taking Abilify 400 mg every 3 weeks (~ 20 mg / day) and 300 mg of Welbutrin. I was complaining to my psychiatrist about the side effects of Abilify I was suffering from; depression (low mood), sexual dysfunction, anhedonia, from a condition called "Neuroleptic Induced Deficit Syndrome" . I complained that I had totally lost my motivation, drive, and initiative and was experiencing anhedonia (lack of pleasure), emotional suppression, etc. It is like living in a mental restraint "straigthjacket". So my psychiatrist added Welbutrin. Abilify dampens down dopaminergic activity in three of the four dopaminergic pathways; It is the only Antipsychotic that I know of that can increase mesocortical dopaminergic activity. Other partial agonists like Brexiprazole and Cariprazine might do this also, whereas a silent antagonist cannot. Welbutrin has treated my low mood; I am euthymic now, but I am still anhedonic from Abilify being so frequent for such a dose; I am taking the daily equivalent of 20 mg: 400 mg per 3 weeks. At lower doses Abilify has a more stimulating effect. The Welbutrin he added certainly helps; but is unfortunately not enough. I am considering adding a dopamine full agonist such as Ropinirole, Rotigotine, Cabergoline and Pramipexole to my prescription meds. Some dopamine agonists are useful at treating depression resistant to SSRI-treatment. Dopamine agonists can be given to counteract the side effects of antipsychotics and serotonergic antidepressants. No doubt that dopamine antagonism has a negative effect on mood. In the mesolimbic pathway *(reward pathway)* Aripriprazole reduces dopaminergic activity; which reduces motivation - salience (liking, rewarding), which can be identified as a major source of anhedonia. Aripriprazole does not reduce dopamine transmission in the mesocortical pathway in people whose mesocortical pathway has .less than normal activity. The dopamine boost that Welbutrin provides keeps me stable; counterbalances some of the negative effects of Abilify. I just need more help in alleviating this zombified state of existence in which I am alienated from my own real self. and cannot enjoy the things I used to enjoy; food, drugs, sex. I live in anhedonia, a state of a loss of pleasure; due to the neurological inhibition caused by Abilify. Welbutrin works as a wakefullness promoting agent, a mild stimulant.

My brief period (6 months) on Sertraline has been that it sapped my creativity and basically made me not want to do anything, not feel anything. I just sit at the computer and watch videos and occasionally walk around, or eat, or go to the bathroom. I just don't have any drive to really do very much of anything, except what is needed for continued survival. I don’t even want to watch movies and series! Is that normal?

So, I have been taking Wellbutrin XL 150mg for 3 days now. It is making me feel REALLY speedy and on edge. Anxiety has gone up to, along with bad insomnia. I have been taking extra Klonopin doses because it gets quite intense, and I usually NEVER have to take any extra klonopin. I was wondering, does this level out at some point where I do not feel like I'm on speed or what? I'm taking this to try and counteract the apathy I feel from Prozac, but honestly if I am going to feel like I did an eight ball all the time...I think I'd rather just deal with the apathy. Has anyone diagnosed with anxiety disorders along with depression had a positive experience from this? Does the anxiety and speediness go away? I also read that some people take Wellbutrin SR 150mg once a day, and that it works better for them. What's the reasoning behind that if you have to take the SR version twice a day? Wouldn't you crash? Thanks for any replies.

l am reaching near 4 years on Prozac. For the past few years, it has worked beautifully, but I'm afraid it is pooping out on me. Lately my mood has been low, completely unmotivated, kinda apathetic. I quit my job and have been just laying in bed. I always thought that if my anxiety/panic is in check and I'm not suicidal, that my AD is working. I am kind of afraid to even switch antidepressants, as it is a whole new change and I fear that maybe Prozac was doing its job. But truly I feel as though Prozac is only working 50%, and when I tried a dose increase it did nothing but make me extremely sleepy and out of it. I am going to talk to my psych about this when I see him in 3 weeks. I just wanted your opinions on if this is the right thing to do. I am going to look for an SNRI such as Effexor or Pristiq (Pristiq more likely, have read good reviews) since I have had success with Remeron in the past, which is serotonergic and noradrenergic. I was also on Wellbutrin as my sole AD in the past but it made me really irritable and did nothing for my anxiety, so I am thinking SNRIs will be the perfect combination for me. On another note, unrelated to ADs, my psych has discussed possible ADHD in me and I am kind of afraid to try a stimulant because 1.) I have had drug abuse problems in the past and 2.) ADHD meds are really expensive, require more often psych visits, and honestly I do not feel as though I have ADHD. When I was prescribed Adderall before I felt really speedy and on edge, and I stopped taking it. Sorry for all the rambling. Let me know what you all think, and thank you. I am very nervous.

Hi everybody. I have been taking Agomelatine for 3 weeks (as an add on to Duloxetine). I don't feel any better. I feel sleepy and slightly more depressed and anxious. How much longershould I keep taking it? Or should I stop? What have others' experiences been? Thanks!

Hello all, I have OCD/Anxiety/Depression I was on: - lexapro: 4 years Started late 2010. 10 increased up to 60 (there was single day 3 pills cant remember 20mg or 10mg high up dose) short time. decreases down to 5. and stop points with rejected change in meds. luvox: 3.5 years started early 2014. 150 ended in 100 decreased down to 50 after that 1.5 weeks attack of continuous eye pains. And stop points with rejected change in meds. and last full stop. What im feeling after approx. 7 months after stopping: 1.5 weeks atack of continuous eye pains. after the attack, right eye pulsating sharp/heating sensation (mostly for now), pains along with easily eye straining and drying, constant red spot/subconjunctival hemorrhage near tear canals reaches to cornea that persists most the day and decreases after sleep for short time.. Did any one experience this type of eye pains before? (what do you advice me/ what should i do?) - return to lowest possible dose and if so, in what size 13.5 or 17.0 or 5 mg or what med, and should I get digital scale? - Waiting while taking coffee and pain killers. - I still get light (with rarely heavy) ocd thoughts/ anxiety/ panic attacks/ depressive mood (current moment they are all mild to me); should I cut all that crap of evaluating with no meds and return to my original dose in sudden. - I don't know if ill ever go to psychological doctors I think the previous docs have a part in the problem. please excuse language and memory errors... Thanks in detail:

Hey guys. Just looking for some opinions here and see who could relate. I’ve been an insomniac for 10 years now and suffered from depression for 5. I recently stopped seroquel 25mg which I was on for 10 years for sleep since it stopped working and made me sedated all day. Changed to ambien 10mg and can FINALLY sleep and feel some energy during the day. My problem is finding th correct med to deal with my depression. I feel like I haven’t felt my confident, creative self in years and homesick for that person to come back if that makes since. Lexapro I was on for three years. Worked okay, but I was also in a daze, so sedated and tired 24/7. And no sexual interest. I then broke down and switched to trintellix, worked well for depression but anxiety it was HORRIBLE. I picked at my face 24/7 and after 7 months went into another breakdown and was very unstable. I was then switched to Wellbutrin and then pristiq. Both turned me into zombies and couldn’t even get out of bed. Finally took genomind test and found out no SSRIS will do the job. So I was put on adderall for resistant depression treatment. That was a fail, ended up in hopsital because I couldn’t stop crying. So I was then put on lamictal which seemed to be okay until I got the rash and am forced to discontinue. Does ANYONE have any reccomendations? I’m just so exhausted of trying everything and not having it work. But hey at least I can sleep on the ambien and that’s half the battle

I wonder whether there´s an SSRI antidepressant also effective for sedation. From my short little search, it seems sedating ADs (Mirtazapine, Doxepine, Trazadone etc.) rather belong to other classes instead of SSRI.

I have a weird symptom that i was wondering if anyone has experienced as well. Anytime I'm on a combination of Geodon and Zoloft, which otherwise has been working well for me, I do these weird things with my hands. My right hand is positioned as if I'm holding a pencil, and I trace shapes repeatedly and quickly. Sometimes it's a triangle, sometimes a square or others... I can stop it when I'm conscious of it, but as soon as I'm not paying attention to it, my hand starts going again. I've tried sitting on my hand and it doesn't help. Then there's my left hand... I hold it as if I'm pill rolling, but without the rolling motion. Over time my grip gets tighter and tighter and it leaves nail marks in my palm. My pdoc has never seen anything like it. He talked to some neurologists and they don't know either. He eventually just said that it's a side effect of being bipolar. I think that's BS because it seems directly related to my meds. I've been on Geodon and Zoloft separately and it didn't happen. But when they are combined, it comes back. I just requested benztropine(Cogentin) because it seems like eps to me (and benztropine helped when I had eps from Risperdal). I'm hoping it helps but either way, I'd like to know if anyone has experienced anything like this. Diagnosis: bipolar 1, adhd, eating disorder, anxiety, etc... Meds: Geodon, Zoloft, Tegretol, Ativan, Cogentin(new)

Hi all, Wanted to get some feedback on the idea behind antidepressants (AD) causing mania in bipolars. I basically got diagnosed because prozac made me manic after awhile. How accurate is that for a diagnoses? I have had other AD's since then with mixed results, but could it just be a "normal" side effect of the med? Thanks, Poem

Ok, I am just curious, I am a 45 year old Mom, have been married for 20 years, have occasionally suffered from depression and anxiety in my life but not consistently. Also ADD, and take Adderall regularly. I had been on anti depressants for short spurts and occasionally anxiety meds as needed. I have never been suicidal or anything and never had a manic episode up until 40. At 40 I was on an Pristiq for about 9 months and decided to go off it cold turkey. I ended up having a manic episode within days and was forcibly hospitalized. The Dr's told me I was bipolar, gave me Depakote and Abilify and sent me home after a while. After being out of the hospital for a year I went off the Depakote and Abilify. I was still feeling a little depression so I started taking Lexapro about a year later I stopped, cold turkey again (brilliant, I know ;-) and had another manic episode and ended up back in the hospital. Doctor's again told me I was bipolar, didn't care that I had stopped anti depressants cold turkey, just handed me a rx for Depakote and Abilify and when I got home I stopped both. Just felt like I didn't belong on them and that they didn't help me. They made me feel crappy and I just didn't have a lot of faith in the Dr's honestly. I know I should go and explain the situation to another Dr. and get an opinion but I just have a lot of anxiety, and feel like most of them don't listen and pre judge. I am just wondering if anyone else has had a situation like this? I STILL don't believe I am bipolar and have not had another episode in 3 years. I stopped the Abilify and Depakote 3 years ago, so I am only on Adderall, which supposedly, from what I've read does cause Mania if you are bipolar and only on a stimulant) I still occasionally struggle with depression occasionally but am terrified to take an anti depressant. I guess I am just trying to see if anyone can relate.... Has anyone else been diagnosed with Bipolar (later in life) from mania, only after stopping an anti depressant? If so, are you still on anti depressants or mood stabilizers? Do you believe your diagnosis, have you been to other Dr's that agree or disagree with it? My husband keeps telling me to move on and realize it probably will never happen again, and was most likely from anti depressant withdrawal, but I feel like I need to know for sure, Is that even possible?? Thanks so much for reading, and for any responses.

Hello there, So I'm going to see my psychiatrist on Thursday to get screened for Bipolar disorder. My hypomania isn't that bad in my opinion (especially when compared to the depths of my depression), but my psychiatrist may still want to put me on a mood stabilizer all the same. I'm scared that she may also try to take me off of Viibryd while she's at it and I'm just unsure of what to expect. I've taken 5mg of Viibryd daily since the Summer of last year (I think), to help give me energy during my depressive states and my questions are: 1) Does anyone else know what it's like to come down from or quit 5mg of viibryd? (Feel free to respond if you took 10mg as well!) 2) What were some withdrawal symptoms you experienced? 3) What helped with the withdrawal? 4) I'm not going to have a seizure if I stop taking Viibryd, right? Sorry, there's a history of epilepsy in my family and that's just a huge phobia.

The med tinkering is driving me nuts. Anyone with me here? Sigh. I have had depression and major depressive episodes for the past 20 years, but I have only been doing the med thing for the past three years. I feel like I get so close to finding a combo that works, albeit with some intolerable side effect... and then I try to get the combo better and wind up making it worse. My latest foray brought back my PMDD crying/depression/irritability for the past week and I'm just at a loss of what to do next. My psychiatric nurse is pretty much up for whatever I want to try, but I don't know what to do anymore. Maybe you all have some ideas? Here's what I'm on right now: Lamictal 200mg (for MDD; *supposed* to be my main antidepressant), Wellbutrin XL 150mg (for giving me more energy and helping with my sex drive), and Lexapro 2.5mg (I had been up to 15mg, but completely lost my ability to orgasm and decided to go off it; hence going on Lamictal). Dx: MDD, PMDD, Primary Insomnia (which may or may not be related to my depression) Antidepressants I've been on: 1) Prozac: numbed me to the point of apathy, caused periodic limb movement disorder at night, sedated me 2) Zoloft 75mg: improvement over Prozac! actually helped me sleep through the night! Yay! Killed my ability to orgasm. Boooo! ... until I added Wellbutrin, then WOW! Sedated me so badly that I only survived on caffeine pills that I had to carefully time through the day, at 100mg every four hours. I hated the sedation (as in I would fall asleep wherever I was multiple times a day if I ran low or out of caffeine), so decided to try something else... 3) Wellbutrin 150mg: Added to help give me my sex drive back. Worked wonderfully! Love this one! Wish it still worked with Lexapro... 4) Lexapro 15mg: Swapped out the side effects. Caused periodic limb movement disorder like Prozac, but NO SEDATION! :-). Sadly, killed my ability to orgasm so completely that not even 300mg Wellbutrin could touch it. I could say that I could live with this, but the endless frustration in my relationship has made me want to pursue another option. 5) Lamictal 200mg: I started this in January of this year, for the purpose of getting off Lexapro, and have been titrating up ever since! Holy crap; it's been forever. Within that seven months, I tried to go off the Lexapro three times. The first two times, my Lamictal was at 100mg and I got down to 7.5mg of Lexapro before having a return of depressive symptoms. This past attempt at going off Lexapro, Lamictal was brought up to 200mg for two weeks before attempting to titrate down on the Lexapro. I titrated by 2.5mg every 5 days and I got down to 2.5mg before having discontinuation symptoms, including depressive symptoms along with headache, irritability, and nausea. So now I'm at 2.5mg of Lexapro and have been holding there, afraid to go off it completely and afraid to go back up. Clearly the 200mg of Lamictal, plus 150mg Wellbutrin are not enough to deal with my depression, particularly the menstrual/hormonal version of it. I was at 200mg of Lamictal for 7 weeks before this last period hit, so I know that there was plenty of time for it to work. If I increase the Lexapro, it defeats the purpose of why I went on the Lamictal. I've never had good anti-depressant results from Wellbutrin, only increased energy, so no reason to go up on that. I am disappointed at the possibility that I've given Lamictal this entire year to work and I don't know if it is marginally working, or not really at all. I'd like to think that the reason I was able to get down to 2.5mg of Lexapro without return of symptoms this time means that the Lamictal is doing *something.* Do I ask to increase the Lamictal? Go up to 300mg? Do I add a different SSRI and go off Lexapro completely? Pdoc thinks I should try Zoloft again. Aaack! Must I live in a sedated state for the rest of my life?! I don't know if there is even the possibility that another SSRI would be better than Lexapro with the side effect profile. But maybe try Celexa and hope for the best? Do I add an antidepressant that is not an SSRI, like Strattera, Abilify, etc.... Since I know y'all are going to ask, I have tried Mirena and Nuva Ring to control the hormone influenced depression and it has been a crap shoot. Mirena turned me into a raging bitch for months and I bled and bled for weeks at a time. So I had that taken out, needless to say. Nuva Ring caused weight gain, pimples, break through bleeding, and did not seem to make any difference with the hormonal depression. So I went off that too. Talk to me, people. Lend me your ideas.

Hello, everybody. I just wanted to post this thread out of curiosity for those of you who have taken Zoloft or Sertraline HCl before. I've been on it for about 5 years now, started at 100mg after titrating up to it for a month or two, and stuck to that for 2 years. After 2 years, I had an episode of anorexia that landed me IP where I was diagnosed with obsessive compulsive personality disorder, and was titrated to 250mg daily at the end of my stay. After leaving, I kept it at 250 with my pdoc, but we decided to go down on it since neither of us thought the dose was having a clinically significant benefit and was just adding more negative side effects. For the past 2 years or so, I've been on 150mg daily, but upped it to 200mg about 2 months ago. It felt like the 150mg wasn't cutting it anymore, and I've found that my anxiety levels have gone down since I went up to 200. I was just curious how many of you guys have been on doses above 100mg, since from what I've read, it seems like most people on Zoloft / Sertraline take about 100mg daily. I've met a couple people on 150mg who have more severe anxiety problems, but few others who have been at 200 or above. Knowing that there are a great deal of affected individuals on this forum, I thought it'd be a fitting context in which to ask what your highest dose was if you've ever been on it, and whether or not you think it was beneficial. Thanks in advance!

Hi all, Is anyone else lost all appetite on Brintellix? First couple of days I was extremely nauseated and simultaneously starving. It was weird. Then later, I had a few days of really, really bad reflux/feeling nauseated (but it's possible that was due to something else). But now that I'm a few weeks in, I'm barely interested in food. I forget to eat. And even if I have something really delicious to eat, I'm barely interested. I don't mind too much. It's better than being nauseated. I just have to make sure that I eat regularly whether I feel like it or not. I was just wondering if anyone else had this issue?

Hi guys, I recently switched doctors. I gave him a list of every med I've ever tried and my results. He said based on how I reacted to those that he thinks Fetizma will work better for me. My Celexa is starting to become less effective, so I want to make a switch. I'm just really scared. I tried to switch to Luvox from Celexa (stopped being effective) last year and it was a nightmare - Luvox didn't work for me and I essentially had no help for a month while my old doctor forced me to wait and see how it made me feel. I cried every day. Had panic attacks. Could barely leave the house. Then my doctor finally relented and let me try something else. I was put on Lexapro. It helped and brought me out of it. But i felt sedated all the time. So I asked to be put back on Celexa. Now 4 months later it's starting to poop out again. I can't function without antidepressants. I've been taking them since I was 12. I have OCD, GAD and panic. Anyway, curious to know if anyone takes it and how they felt on it? I just figured it might make me feel better to read other people's reviews. Wish me luck. Thanks, Steph Just for a little background... I've taken: Effexor - results were ok Wellbutrin - made me feel crazy Celexa - worked well for a long time but pooped out Lexapro - worked but felt sedated. Luvox - no effect. Anafranil - made me feel weird. Vybriid - terrible side effects; couldn't get past it. abilify - made my anxiety worse. risperdal - made my anxiety worse. seroquel - made my anxiety worse.

I have a relatively new psychiatrist and she's afraid to prescribe me antidepressants because it might make me manic or psychotic. I've been on sertraline before (along with lithium) and it didn't do that to me so I don't see the problem. Anybody out there bipolar and prescribed an antidepressant? If so how is it working for your anxiety? Which antidepressant are you on? I really need to kick this anxiety in the butt before I completely shut down.

I was recently prescribed Wellbutrin to go along with Lamotrigine (300 mg). I take Xanax, as needed. I was desperate. The depression, well, many of you know what that's like and how much can begin to fall apart/pile up around you. Just wondering - Anyone with BP have stories of experience on these two medications alone? Mainly curious. I'm trying it out either way. Years ago, I was on quite a cocktail of meds, but I try my hardest to limit them now...until I can't. It has been taking me a good three hours to be able to lift my body out of bed each morning, among other depression issues. Something had to change.

I have been on Wellbutrin 150 mg on 3 weeks and 5 days, just 4 days ago i started to feel the positive effect. My depression has definitely lifted, i enjoy life again and i've got more energy and motivation. But the depression is still there, i'm still not where i used to be. So i want to try increasing the dosage of Wellbutrin to 300mg to make the positive effect even stronger. But my doctor has told me she's seen patients get emotionally flat/lose their creativity on 300 mg, so i am here to ask any of you who are currently taking Wellbutrin 300 mg or have been on it before. Did you feel any sign of emotional flatness or lost creativity? Or did it make you feel even better than on 150 mg? No negative stories about the medication in general please, i'm only interested in hearing how you felt when you were on 300 mg of Wellbutrin.

I've been taking Bupropion for about three weeks now and it makes me shaky, sometimes more than others. I've been prescribed Alprazolam, twice a day as needed, to help get through this. Anyone else have this issue, and, if so, does it ever seem to settle? Also, I know it has stimulant-like qualities, but I'm wondering if I'll get used to them.

Hi, Has anyone taking antidepressants ever been thrown into a bad depressive episode while taking an antibiotic? I have been taking Paxil for a while and recently got the flu with it turning into a sinus infection. I was prescribed Levofloxacin for the infection but since taking it I have been getting worse mentally and emotionally. I am in a full blown depressive episode and am looking for some hope that this is because of the antibiotic. I took 5 daily pills of a 10 day dose for the Levofloxacin and decided to stop after todays dose. Please let me know if you have experienced this. Thanks, Looking for some hope.