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  1. I've been reading the following articles: https://psychotropical.info/clomipramine-potent-snri-anti-depressant/ https://psychotropical.info/tca-intro/ https://psychotropical.info/snri-intro/ Seems to be a pretty potent drug: SNRI, antagonist of the alpha1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system; so that speaks for itself.
  2. So Effexor XR is the best medication I've taken for my problems which combined anxiety disorders, panic disorder, and obsessions. It has also helped with depression that inevitably follows these... So I know the SSRIs/SNRIs are notorious for this side effect, I was just wondering how other users deal with this problem as this can be difficult to talk about with peers and even doctors? I don't even like posting this here, I just don't know what to do. I was on Effexor XR for about 5 years at 300mg, last year I came down to 150mg, and currently I'm on 75mg. Luckily I've felt pretty stab
  3. Hi Everyone, Yep, I did it. I am indeed an idiot. I forgot I took my 11am 40mg Celexa yesterday morning and took another 40mg at 2pm. Then I forgot I did THAT and took my regular 11am dose this morning, so I'm hurting. Weird nausea thing happening in my head right now, but I don't think it's bad enough to go to the hospital. Anything I can do other than wait it out? I've got so much work to do. I deeply appreciate any help. LMN
  4. Welbutrin (Bupropion) is a dopamine-norepinephrine reuptake inhibitor; its occupancy at dopamine transporter (DAT) is 23%; whereas over 75% causes euphoria (ex. cocaine). A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron. This results in increased extracellular concentrations of dopamine and increase in dop
  5. My brief period (6 months) on Sertraline has been that it sapped my creativity and basically made me not want to do anything, not feel anything. I just sit at the computer and watch videos and occasionally walk around, or eat, or go to the bathroom. I just don't have any drive to really do very much of anything, except what is needed for continued survival. I don’t even want to watch movies and series! Is that normal?
  6. So, I have been taking Wellbutrin XL 150mg for 3 days now. It is making me feel REALLY speedy and on edge. Anxiety has gone up to, along with bad insomnia. I have been taking extra Klonopin doses because it gets quite intense, and I usually NEVER have to take any extra klonopin. I was wondering, does this level out at some point where I do not feel like I'm on speed or what? I'm taking this to try and counteract the apathy I feel from Prozac, but honestly if I am going to feel like I did an eight ball all the time...I think I'd rather just deal with the apathy. Has anyone diagnosed with anxiet
  7. l am reaching near 4 years on Prozac. For the past few years, it has worked beautifully, but I'm afraid it is pooping out on me. Lately my mood has been low, completely unmotivated, kinda apathetic. I quit my job and have been just laying in bed. I always thought that if my anxiety/panic is in check and I'm not suicidal, that my AD is working. I am kind of afraid to even switch antidepressants, as it is a whole new change and I fear that maybe Prozac was doing its job. But truly I feel as though Prozac is only working 50%, and when I tried a dose increase it did nothing but make me extremely s
  8. Hi everybody. I have been taking Agomelatine for 3 weeks (as an add on to Duloxetine). I don't feel any better. I feel sleepy and slightly more depressed and anxious. How much longershould I keep taking it? Or should I stop? What have others' experiences been? Thanks!
  9. Hello all, I have OCD/Anxiety/Depression I was on: - lexapro: 4 years Started late 2010. 10 increased up to 60 (there was single day 3 pills cant remember 20mg or 10mg high up dose) short time. decreases down to 5. and stop points with rejected change in meds. luvox: 3.5 years started early 2014. 150 ended in 100 decreased down to 50 after that 1.5 weeks attack of continuous eye pains. And stop points with rejected change in meds. and last full stop. What im feeling after approx. 7 months after stopping: 1.5 weeks atack of continuous eye pains. after the attack, righ
  10. Hey guys. Just looking for some opinions here and see who could relate. I’ve been an insomniac for 10 years now and suffered from depression for 5. I recently stopped seroquel 25mg which I was on for 10 years for sleep since it stopped working and made me sedated all day. Changed to ambien 10mg and can FINALLY sleep and feel some energy during the day. My problem is finding th correct med to deal with my depression. I feel like I haven’t felt my confident, creative self in years and homesick for that person to come back if that makes since. Lexapro I was on for three years. Wo
  11. I wonder whether there´s an SSRI antidepressant also effective for sedation. From my short little search, it seems sedating ADs (Mirtazapine, Doxepine, Trazadone etc.) rather belong to other classes instead of SSRI.
  12. I have a weird symptom that i was wondering if anyone has experienced as well. Anytime I'm on a combination of Geodon and Zoloft, which otherwise has been working well for me, I do these weird things with my hands. My right hand is positioned as if I'm holding a pencil, and I trace shapes repeatedly and quickly. Sometimes it's a triangle, sometimes a square or others... I can stop it when I'm conscious of it, but as soon as I'm not paying attention to it, my hand starts going again. I've tried sitting on my hand and it doesn't help. Then there's my left hand... I hold it as if I'm pill rolling
  13. Hi all, Wanted to get some feedback on the idea behind antidepressants (AD) causing mania in bipolars. I basically got diagnosed because prozac made me manic after awhile. How accurate is that for a diagnoses? I have had other AD's since then with mixed results, but could it just be a "normal" side effect of the med? Thanks, Poem
  14. Ok, I am just curious, I am a 45 year old Mom, have been married for 20 years, have occasionally suffered from depression and anxiety in my life but not consistently. Also ADD, and take Adderall regularly. I had been on anti depressants for short spurts and occasionally anxiety meds as needed. I have never been suicidal or anything and never had a manic episode up until 40. At 40 I was on an Pristiq for about 9 months and decided to go off it cold turkey. I ended up having a manic episode within days and was forcibly hospitalized. The Dr's told me I was bipolar, gave me Depakote and Abili
  15. Hello there, So I'm going to see my psychiatrist on Thursday to get screened for Bipolar disorder. My hypomania isn't that bad in my opinion (especially when compared to the depths of my depression), but my psychiatrist may still want to put me on a mood stabilizer all the same. I'm scared that she may also try to take me off of Viibryd while she's at it and I'm just unsure of what to expect. I've taken 5mg of Viibryd daily since the Summer of last year (I think), to help give me energy during my depressive states and my questions are: 1) Does anyone else know what it's like to come
  16. The med tinkering is driving me nuts. Anyone with me here? Sigh. I have had depression and major depressive episodes for the past 20 years, but I have only been doing the med thing for the past three years. I feel like I get so close to finding a combo that works, albeit with some intolerable side effect... and then I try to get the combo better and wind up making it worse. My latest foray brought back my PMDD crying/depression/irritability for the past week and I'm just at a loss of what to do next. My psychiatric nurse is pretty much up for whatever I want to try, but I don't know what to do
  17. Hello, everybody. I just wanted to post this thread out of curiosity for those of you who have taken Zoloft or Sertraline HCl before. I've been on it for about 5 years now, started at 100mg after titrating up to it for a month or two, and stuck to that for 2 years. After 2 years, I had an episode of anorexia that landed me IP where I was diagnosed with obsessive compulsive personality disorder, and was titrated to 250mg daily at the end of my stay. After leaving, I kept it at 250 with my pdoc, but we decided to go down on it since neither of us thought the dose was having a clinically sign
  18. Hi all, Is anyone else lost all appetite on Brintellix? First couple of days I was extremely nauseated and simultaneously starving. It was weird. Then later, I had a few days of really, really bad reflux/feeling nauseated (but it's possible that was due to something else). But now that I'm a few weeks in, I'm barely interested in food. I forget to eat. And even if I have something really delicious to eat, I'm barely interested. I don't mind too much. It's better than being nauseated. I just have to make sure that I eat regularly whether I feel like it or not. I was just wondering if anyone e
  19. Hi guys, I recently switched doctors. I gave him a list of every med I've ever tried and my results. He said based on how I reacted to those that he thinks Fetizma will work better for me. My Celexa is starting to become less effective, so I want to make a switch. I'm just really scared. I tried to switch to Luvox from Celexa (stopped being effective) last year and it was a nightmare - Luvox didn't work for me and I essentially had no help for a month while my old doctor forced me to wait and see how it made me feel. I cried every day. Had panic attacks. Could barely leave the house. Then
  20. I have a relatively new psychiatrist and she's afraid to prescribe me antidepressants because it might make me manic or psychotic. I've been on sertraline before (along with lithium) and it didn't do that to me so I don't see the problem. Anybody out there bipolar and prescribed an antidepressant? If so how is it working for your anxiety? Which antidepressant are you on? I really need to kick this anxiety in the butt before I completely shut down.
  21. I was recently prescribed Wellbutrin to go along with Lamotrigine (300 mg). I take Xanax, as needed. I was desperate. The depression, well, many of you know what that's like and how much can begin to fall apart/pile up around you. Just wondering - Anyone with BP have stories of experience on these two medications alone? Mainly curious. I'm trying it out either way. Years ago, I was on quite a cocktail of meds, but I try my hardest to limit them now...until I can't. It has been taking me a good three hours to be able to lift my body out of bed each morning, among other depression issues. Somet
  22. I have been on Wellbutrin 150 mg on 3 weeks and 5 days, just 4 days ago i started to feel the positive effect. My depression has definitely lifted, i enjoy life again and i've got more energy and motivation. But the depression is still there, i'm still not where i used to be. So i want to try increasing the dosage of Wellbutrin to 300mg to make the positive effect even stronger. But my doctor has told me she's seen patients get emotionally flat/lose their creativity on 300 mg, so i am here to ask any of you who are currently taking Wellbutrin 300 mg or have been on it before. Did you feel any
  23. I've been taking Bupropion for about three weeks now and it makes me shaky, sometimes more than others. I've been prescribed Alprazolam, twice a day as needed, to help get through this. Anyone else have this issue, and, if so, does it ever seem to settle? Also, I know it has stimulant-like qualities, but I'm wondering if I'll get used to them.
  24. Hi, Has anyone taking antidepressants ever been thrown into a bad depressive episode while taking an antibiotic? I have been taking Paxil for a while and recently got the flu with it turning into a sinus infection. I was prescribed Levofloxacin for the infection but since taking it I have been getting worse mentally and emotionally. I am in a full blown depressive episode and am looking for some hope that this is because of the antibiotic. I took 5 daily pills of a 10 day dose for the Levofloxacin and decided to stop after todays dose. Please let me know if you have experienced this. Tha
  25. My whole mental health deal has been a huge fiasco from july 2013 to january 2014, 4 hospitalizations, 2 IOP/partial hospitalizations, and every med you can think of (except the good ones) I've been on 10mg of focalin, 150mg of wellbutrin sr and 300mg of seroquel (supposed to be daily, I just take it when I cant sleep) and .2mg clonidine. I stopped the wellbutrin myself a few weeks ago because I couldn't stand the taste of cigarettes and lack of nicotine buzz. Well, yesterday my PDOC put me on lexapro. The last SSRI I remember was prozac, and it made me feel like I was on dxm all the time,
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