Search the Community

For those taking Rexulti, I'm curious: Do you take your dose in the morning or at night?

Hello everyone, I hope everyone's December has been off to a good start. I am back, on the med merry-go-round and also sober from opiates.... Again (16 days as of now). So I was taking wellbutrin as an add on to my Prozac, and it really didn't help and might have made me worse, losing dramatic amounts of weight, a lot of intrusive thoughts, very depressed (though that's probably just it not doing much for it. And getting off drugs.) so I'm now on the Rexulti starter pack. I'm here seeking others experiences with abilify and rexulti, since they are both dopamine partial agonists and 5-ht1a partial agonists, amongst other things. I'm very nervous about taking an antipsychotic for depression, though... And just want to know of other's experiences starting these medications. How were the side effects? If you had any, did they eventually go away? Did you gain weight? I appreciate anyone who shares their experience. I've asked about these meds before, but I'm so nervous about it I just want reassurance. A lot is changing around me. Thank you all so much, and I hope the holidays have been treating you well.

Hi there, I was just wondering if anyone here has tried Rexulti as an AD adjunct for depression. Please tell me what you thought of it, I know it's very similar to Abilify, but surprisingly Rexulti under my insurance + the manufacturer discount card is cheaper than generic Abilify, so I want to get familiar with it. I have only had one true experience with an AAP, Seroquel, and it was actually really nice but it made me sleep like a rock, so I got off it years ago. I'm not switching to Rexulti at the moment, but my psych let me know it's the next option if Wellbutrin doesn't work out. Again, let me know your experiences with it, and I guess Abilify too since they are similar. The thought of being on an AAP scares me, with all the side effects and such, especially for depression. But I have read Rexulti and Abilify both have "pro-cognitive" effects which is exactly what I need. Also, has it helped with your anxiety at all? Do AAPs generally help with anxiety? Because if I'd be able to get off Klonopin that would be a plus. Thank you all for any replies!

Just wondering if anyone out there has had any experiences with the medication Rexulti (brexpiprazole)? My psychiatrist chose to give this a try (2mg) after evaluating and attempting to treat my persistent manic symptoms -- I would go days without sleeping and not feel tired, racing ideas and thoughts, increased in "goal-directed" activity like cleaning the kitchen for hours and sexual promiscuity, inflated self-esteem, inattention or inability to focus, pressured speech, rapid talking, and hyperactivity. Seroquel is super effective for stopping my mania but the negative cognitive effect and zombification I experienced were too much, and this was only at 50-100mg If you have tried Rexulti please share your experiences with it in terms of treating your symptoms of bipolar disorder, whether or not it worked for you, side effects you experiences, and the main symptoms that resulted in you trying this medication. So far it has been about a week on Rexulti 2mg, and I am beginning to notice a slight increased in motivation and better time-management, which really surprised me given my past experiences with AAPs. This could be due to other medication, as my dexedrine dose has increased from 40mg to 60mg, but I have been on this high of a dose in the past and not noticed the increased thought organization and motivation to complete tasks/assignments before the last minute. It hasn't directly induced sleep as Seroquel did, but I do notice I am getting on a better schedule. Also, if you have not tried Rexulti but have been on Abilify (aripiprazole), I would be happy to hear your experiences as well, given that the two are similar in structure and chemical composition (I acknowledge that despite this, the two can still have very different and distinct effects).

Does anyone else have experience with Rexulti completely destroying their depression? For me, Rexulti almost had a same day anti-depressant effect and controls depressive episodes acutely and astoundingly fast. I literally feel anti-depressant effects in as little as 3 hours after I take it. When I look back to when I was on it, I now realize that I didn't have a single bout of depression during that time, it just was not super effective in controlling mania. I think Rexulti is a hell of an anti-depressant, a way improved drug than abilify with less than half the side effects, no lethargy or cognitive impairment either which is always surprising to find in an antipsychotic. I know it has an indication for adjunctive therapy in adults with MDD but none for bipolar depression... maybe Lundbeck is just waiting for close to the expiration of the patent before the release new clinical trial data and extend their patent after they get the bipolar depression indication approved, but that's just a thought. Anyone else have a similar experience with Rexulti, brexpiprazole? Please let me know about your time on the medication and if it sat well with you or not so much. Interested in if others are also getting this rapid and significant anti-depressant effect from this drug or if it's just me

Hello everyone. Did a search on the forums and found that there weren't any recent threads compiling everyone's experiences of Rexulti. I've recently started taking Depakote. I hit a mixed state and we went up to 25mg on loxapine to compensate but it caused too much akathisia and we needed something to stabilize me quickly without using the higher dose of loxapine. Depakote did a better job of that than the oxcarbazepine that I was taking originally. Now that I've titrated up to 1000mg, I feel like it does a mostly good job at getting me to a better baseline. Just went to 1500mg for 3 days and had to go back down to 1000mg because I started to become depressed. Now that I've reduced it back down, those depressed feelings have gone away. I have more pep back in my step and I'm more engaged in my work. No issue really. The only problem is that I sometimes have breakthrough anxiety that I manage with 0.5mg of alprazolam or 5mg of loxapine depending on if it leans more towards anxiety/panic or leans more towards intrusive thoughts (respectively). I would like to rely on PRNs less, and I've been thinking about swapping out my nightly 10mg of loxapine for a daily dose of Rexulti. Could still use the 5mg loxapine PRN along with the alprazolam but I wanted to aggregate people's experiences in one thread to get all the data before I make a decision. My next pdoc appt is 11/17. Ok, go!