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Found 6 results

  1. https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/clomipramine-tryptophan-and-lithium-in-combination-for-resistant-endogenous-depression-seven-case-studies/F3A1B19433959744DCF32C36C7B4A28F# Unquestionably an extreme combination, but it seems to exhibit powerful antidepressant effects. Clomipramine on its own is regarded by many as maybe the most powerful non-MAOI antidepressant, at least in clinical practice and inpatient care, although the side effects can be quite rough, but combined with Tryptophan and Lithium it seems to be further boosted in its effect size and response rate. Maybe worth trying before hopping on ECT / MAOIs... One has to be careful because it is a small sample case "study", but nonetheless quite interesting to read. I encourage all those who have a view or experience to share it with us, regarding the aforementioned medications and especially the combination. Greetings!
  2. Sertraline standalone makes many people somewhat apathetic, indifferent and unmotivated, and that's why doctor Gillman suggests augmenting it with Nortriptyline OR alternatively taking Clomipramine standalone for the full SNRI effect... Did anyone here try both combos? I am getting back on antidepressants and not sure how to proceed... but if I had to choose, I would preferably go for one of the two possibilities.
  3. I've been reading the following articles: https://psychotropical.info/clomipramine-potent-snri-anti-depressant/ https://psychotropical.info/tca-intro/ https://psychotropical.info/snri-intro/ Seems to be a pretty potent drug: SNRI, antagonist of the alpha1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system; so that speaks for itself. The reviews on drugs.com and other sites also are quite positive. The following ranking is interesting: http://slatestarcodex.com/2015/04/30/prescriptions-paradoxes-and-perversities/ These numbers are based on aggregated patient ratings. Top 4 drugs: # Nardil 1.25 # Parnate 1.23 # Chlomipramine 1.22 # Emsam/selegeline 1.07 => Clomipramine roughly on pair with MAOI, followed by Nefazodone (R.I.P) and Imipramine. Imipramine is also a potent SNRI, but lacks the strong 5HT-antagonism compared to Clomipramine. I suppose that's the pharmacological difference which makes Clomipramine superior... ? Clomipramine exhibits some antagonism of dopamine D1, D2 and D3 receptors... can one expect some clinical & therapeutic benefits from this? Clomipramine acts as a functional (potent!) inhibitor of acid sphingomyelinase (FIASMA): http://en.wikipedia.org/wiki/FIASMA Some interesting graphs regarding antidepressant FIASMAs: http://d-nb.info/1011278227/34 Who here has been on Clomipramine and what were your experiences with it?
  4. I know this is a Tricyclic antidepressant and i was wondering how it has worked for you? I was thinking of taking it because i have OCD and i also have bipolar. So don't want it affecting my mood disorder in a negative way. What side affects did you experience? How long did it take before you noticed a change? And if you have bipolar... did it affect your bipolar at all?
  5. Hi everybody! A while ago I asked about switching to MAOIs from tricyclics. I ended up switching from imipramine to clomipramine instead with (surprise!) no results. Now I'm actually making the switch from clomipramine to Nardil/phenelzine. I just wanted to know of anybody who has been on Nardil, what side effects they had and how they found it, especially those suffering from severe or treatment resistant depression. I have a history of serotonin syndrome which worries me a bit but I'm going up slow (15mg a week) with a seven day washout. Hopefully, since my SS is usually caused by combinations of tricyclics with Pristiq, I will be okay but I'd like to know if anybody else has had problems and what helped/didn't. I am scared but I always hate switching meds and I'm pretty miserable at the moment as well. If anybody wants to talk to me that'd be great. I'm exhausting myself worrying and just want concrete information, be it good or bad, to arm myself against the fancy conjured by my imagination. Thanks gang.
  6. I was put on Clomipramine two and a half weeks ago. Recently every night I've caught myself gesturing or talking in my sleep. Nothing violent or scarey and I'm not sleep walking, just lweird little things like lightly kicking, making a hand gesture, once I even chewed on the corner of my pillow (I think I was dreaming about eating). And I also talk which wakes me up. This stuff happens during the time right before you start waking up, I don't know if it happens any other time. Before this I only moved or talked in my sleep rarely, I quess about the frequency "normal" sleeper would have. This started a few days after I started on Clomipramine, but searching on the internet hasn't brought up anything like this connected to it.
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