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I am taking stimulants for numerous reasons--primarily for ADHD and idiopathic hypersomnia, but also because I'm obese and trying to lose weight (with diet and exercise of course) and because amphetamines heretofore have been the only thing that really make me a functioning human being. I was curious though. From y'all's experience, which stimulant inhibited appetite and/or caused more weight loss, that is, between Ritalin (and all their products), Focalin, Adderall, Dexedrine, or some other stimulant. I have actually even taken Desoxyn, twice, and to be honest, it's nowhere near as potent as Adderall or Dexedrine. To my understanding, appetite inhibition can be extricable from weight loss; i.e., one can lose weight from a medicine without experiencing much appetite suppression, one can experience drug-induced anorexia without losing much weight, or both at the same time, or neither. IME, so far, this is what I've experienced... I'll list the stimulant/anorectic and max dose taken. Appetite suppression/anorexia: Dexedrine (60 mg) Adderall (60 mg) Dexedrine Spansules (30 mg) Adipex-P (37.5 mg) Adderall XR (90 mg) Wellbutrin IR/SR/XL (450-500 mg) Bontril-PDM (210 mg) Tenuate (75 mg) Desoxyn (15 mg) Vyvanse (70 mg) Adzenys XR-ODT Metadate CD (20 mg) Ritalin (30 mg) Focalin XR (25 mg) Evekeo (20 mg) Belviq XR (20 mg) Tenuate Dospan (75 mg) Contrave (32 mg/360 mg) Weight loss: Dexedrine (60 mg) Adderall (60 mg) Adipex-P (37.5 mg) Tenuate (75 mg) Dexedrine Spansules (30 mg), Adderall XR (90 mg) Wellbutrin IR/SR/XL Desoxyn (15 mg) Bontril-PDM (210 mg) Metadate CD (20 mg) Belviq XR (20 mg), Evekeo (20 mg), Focalin XR (25 mg), Ritalin (30 mg), Vyvanse (70 mg) Contrave (32 mg/360 mg), Tenuate Dospan (75 mg), Adzenys XR-ODT So I've not tried very high doses of the (dex)methylphenidate meds, and have been curious about trying a higher dose (40-60 mg, maybe higher). Focalin might be okay, but it gave me tremors, anxiety, and panic attacks at 25 mg. Vyvanse did nothing much at all except jack my resting heart rate up to 120+ BPM. This list was very hard to compile, and I don't really know if it's too accurate. I'm heavily considering trying methylphenidate again, specifically Metadate CD, because I actually felt something on it as opposed to regular Ritalin. I was considering asking my NP for a Metadate CD dose of 30-60 mg, or maybe 30 mg x2 or something like that, with some Ritalin 5-10 mg, maybe 20 mg, to take 1/2-1 up to three times per day prn. The tried and true med is Dexedrine for me, specifically the IR, but I want to give that a break for a little while. I'm curious to see how (dex)methylphenidate affects my ADHD more than it affects my weight loss/appetite suppression as well. I know this post was rather scattered and long, but if you made it through it, any input would be much appreciated!

I somehow ran out of Dexedrine before my next prescription was labeled to be able to be filled this past weekend... Don't know how. I never abuse my stimulants. I take them as prescribed, religiously and meticulously, dispensed in my pill planner every week. I have heretofore never taken "drug holidays" though. So anyway, this forced me to take a one-day drug holiday from my usual 60 mg/day Dexedrine, and I can say that it was absolutely dreadful. I'm taking it mainly for ADHD-PI, but also for treatment resistant bipolar depression and hypersomnia unspecified, as well as to assist with weight loss. Just one day without, and I slept practically all day, and when I wasn't asleep, I was either a weeping, ugly-crying mess, or I was binge eating. I gained 3 lb the next day, which I know isn't a whole bunch, but, you know... I'm pretty sensitive about weight gain. I filled my Dexedrine a day later than the day was indicated so as to not look like I was "looking for a fix..." especially since I'm trying to get a job at the pharmacy at which I fill my prescriptions, start back on my Dexedrine, and two days later (today), I am feeling better than I've felt in about in month or so (before I switched to Rexulti and ruined everything good I had going for me). I felt like I did right when I switched from 40 mg to 60 mg, my mood was shining and gleaming, I was talkative and laughing, I wanted to do things and wanted to go out of the house, I didn't want to eat everything in sight. TL;DR: I was back to my normal self +1. My question is, would there be some advantage to taking some sort of "pseudo-drug holiday" wherein I sort of alternate between 30 mg and 60 mg each day, or take 30 mg on the weekends and 60 mg during the week days or something like that? Or no? Has anyone tried this sort of regimen? I don't want to NOT take my Dexedrine, that was pretty damn terrible the day I went without it. I guess it does show how dependent I am on it though... But any input would be appreciated.

Hey all, I have been experiencing some anhedonia lately and just not experiencing feelings much at all in general. I feel like I don't want to talk to as many people or interact like I usually would. There's is't much pleasure in doing the things I usually do, and simple things like showering or going downstairs to get my mail are difficult to get the motivation to do it. I don't think I am depressed because I'm not feeling sad or unhappy, I am more just suffering from lack of ability to derive pleasure from things that once gave me pleasure and a general lack of emotions. I notice the anhedonia is especially noticeable when I am on my ADHD medications and it really sucks. Given the other medications I am on, it could easily be due to one of the other medications or a combination. Does anyone else experience lack of emotions and/or anhedonia when they are on their ADHD medications? What about when you are off them/you have 'come down' from the drug. I can feel my emotions, they just seem heavily suppressed. I can feel happy, sad, excited, but to a small degree compared to before, I guess the beginning of the year. You can see the rest of my medications in my signature if you want to comment on any of those in relation to this.

My insurance pooped out and it's going to be another day or so before I can fill my dexedrine prescription. I'm entirely out. In the past, when I've tried to take a break, I've experienced crushing depression, even after a day. I've read it can start after 12 hours, and I took my last dose around noon today. Hopefully will be able to pick up more tomorrow afternoon, but I'm worried that I will go way down and not even be able to leave the house to get to the pharmacy (agoraphobia/depression). So I've taken the advice I've read online: tyrosine every two hours, continuation of clonazepam, and magnesium/b/c. Wondering if I can (or should) combine it with one of the other many drugs I have around the house that I've previously taken: Topamax (saw clinical study showing that has been shown effective in preventing relapse in meth addicts) Olanzapine Cymbalta/duloxetine (saw some doctors prescribe for this purpose) An increase of the celexa I currently take Trazadone (again, saw that is recommended) Does anyone know whether this would be advisable, on a very short-term basis, given the other meds I take (hopefully included in my signature). Would really appreciate any help to head off crippling depression tomorrow (or even longer, depending on how long my damn insurance company takes to get it together). Thanks.

I've been taking Adderall IR for a little while now (few months) taking 30mg at 8am and another 15mg at noon, and recently just added Remeron 15mg every night for sleep. I've been noticing a major fluctuation in my moods about 1-2 hours after taking the Remeron. So in addition to the somewhat slumped feeling I had already from the daytime meds wearing off, once the night med kicks in I am just like totally depressed and out of it. Has anyone else tried this combination and what effects did you see occur?