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I somehow ran out of Dexedrine before my next prescription was labeled to be able to be filled this past weekend... Don't know how. I never abuse my stimulants. I take them as prescribed, religiously and meticulously, dispensed in my pill planner every week. I have heretofore never taken "drug holidays" though. So anyway, this forced me to take a one-day drug holiday from my usual 60 mg/day Dexedrine, and I can say that it was absolutely dreadful. I'm taking it mainly for ADHD-PI, but also for treatment resistant bipolar depression and hypersomnia unspecified, as well as to assist with weight loss. Just one day without, and I slept practically all day, and when I wasn't asleep, I was either a weeping, ugly-crying mess, or I was binge eating. I gained 3 lb the next day, which I know isn't a whole bunch, but, you know... I'm pretty sensitive about weight gain. I filled my Dexedrine a day later than the day was indicated so as to not look like I was "looking for a fix..." especially since I'm trying to get a job at the pharmacy at which I fill my prescriptions, start back on my Dexedrine, and two days later (today), I am feeling better than I've felt in about in month or so (before I switched to Rexulti and ruined everything good I had going for me). I felt like I did right when I switched from 40 mg to 60 mg, my mood was shining and gleaming, I was talkative and laughing, I wanted to do things and wanted to go out of the house, I didn't want to eat everything in sight. TL;DR: I was back to my normal self +1. My question is, would there be some advantage to taking some sort of "pseudo-drug holiday" wherein I sort of alternate between 30 mg and 60 mg each day, or take 30 mg on the weekends and 60 mg during the week days or something like that? Or no? Has anyone tried this sort of regimen? I don't want to NOT take my Dexedrine, that was pretty damn terrible the day I went without it. I guess it does show how dependent I am on it though... But any input would be appreciated.