Search the Community

https://en.wikipedia.org/wiki/Amitriptyline https://en.wikipedia.org/wiki/Nortriptyline Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite. When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition) What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically) binding affinities: picture source: https://abload.de/img/nortgpk1f.png

I've been prescribed amitriptyline to take at night for my depression, anxiety, chronic fatigue and pain. I see it has been out for a long time. Does anyone know if there are any particular generic manufacturers that are better than others for this med? I ask because on several other meds in the past I could notice a significant difference from certain generic drug makers, especially with paxil, effexor, and klonopin. I know its supposed to be "therapeutically equivalent" but they can definitely vary. Thank you.

First off - if anything here is screwy please just yell at me via PM, I'm a very new user and still learning the ropes. Mods, if this isn't acceptable as far as posts go, feel free to delete. Anyhow - Has anyone experienced misophonia/sensory processing issues after coming off cymbalta? I'm about 2 weeks from taking my last dose and switching to elavil and within the last couple of days it's gotten to where I just cannot STAND certain textures/sounds. Popcorn against my teeth, too-dry towels, certain plastic bags rubbing against themselves - they all just make me want to burst into tears because they're so overwhelmingly awful. I can barely put the experience into words, it's that negative. I would chalk this up to some undiagnosed aneurotypicality (sheesh, how's that for big words) except it's come on really suddenly in the past couple days. I have all this popcorn I can't eat because it's too squidgey against my teeth, it's awful. So far cymbalta withdrawal is the best I've got but I really have no idea. I've followed it up with my psych (who straight up said he didn't know anything - cymbalta withdrawal is my diagnosis, not his) and am going to follow it up with a neurologist but I just wanted to know if this is something somebody else has had experience with too.