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Is it possible that a brain becomes immune to working mechanism SSRI's for long time users? So there can be side effects but no effect on thing you are taking it for? I can't find anything on this on the internet. I know individual SSRI's have different properties, but I wonder if they could also do some kind of 'damage' (I'm not talking about withdrawal and recovery). Like insensitive / insusceptible? I've been using Luvox(2/3 years) and Lexapro (6/7 years) and now Zoloft, which I have been on for 6 months (200 mg for almost about 1,5 months). But Zoloft doesn't like the other two, not much effect on my intrusive thoughts. I've read from a lot of people that SSRI's don't work as good when you restart the same one. I had this experience with Luvox, when I took it for the third time in two years time. I then switched to Lexapro and it worked great! But now I'm not so lucky and I wonder WHY my brain isn't responding the way I like. Apart from mild side effects I'm not getting the same relief from Zoloft. If anyone has more (indepth) info that would be AWESOME! :-)